乳腺浸润性导管癌生长方式的体视学参数和组织学分级与预后关系的评价
作者：裴素丽 姜红光 赵冬梅 乔思杰
单位：河南省肿瘤医院病理科 郑州 450003
关键词：乳腺肿瘤；体视学；组织学分级；预后
诊断病理学杂志000115摘 要：目的 推荐一个乳腺浸润性导管癌的预后指标一癌巢的表面积密度(Sv)。方法 以Bloom-Richardson和Elston分级法，对343例乳腺浸润性导管癌进行组织学分级并根据体视学原理，采用模板法，测定癌实质体积密度(Vv)及癌巢的表面积密度(Sv)。比较它们与预后的相关性。结果 在与预后有显著相关性的癌组织学分级、癌实质体积密度(Vv)及癌巢的表面积密度(SV)中发现，SV≤4.4的患者中，89.3%生存5年以上，Sv>5.5的患者中，82.5%死于5年以内。结论 癌肿生长方式的体视学参数—Sv是可靠且独立的预后指标，Vv、组织学分级是乳腺浸润性导管癌预后的相关因素。
, 百拇医药
分类号：R737.9 文献标识码：A
文章编号：1007-8096(2000)01-0042-03
Prognostic evaluation of the stereologic parameters of growth pattern and histologic grade in invasive ductal carcinoma of the breast
Pei Suli,Jang Hongguang,Zhao Dongmei
(Department of Pothology, Henan Tumor Hospital,Zhengzhou 450003)
Abstract：Objective To recommend a prognostic factor,surface area density (Sv) of carcinomas nest,in invasive ductal carcinoma(IDC)of the breast. Methods 343 cases of IDC with more than 5 years follow-up wem graded according to the grad-ing systems of Bloom-Richardson and Elston.Their volume density (Vv) of carcinomas parenchyme and surface area density (Sv)of carcinomas nest were measured with stereologic method, and the correlation of the three variables with prognosis were investigat-ed. Results Five-year survival was 89.3% among the patients with Sv≤4.4, where as 82.5% of the patients with Sv>5.5 died within five years. Conclusion Sv is a reliable and independent prognostic factor for patients with breast IDC.
, 百拇医药
Keywords：Breast neoplasm Stereology Histologic grade Prognosis
参考文献：
[1]阙秀.乳腺癌临床病理学.北京：北京医科大学，中国协和医科大学联合出版社，1993.117-127
[2]柳剑英，吕英志，张宏伟，等.乳腺癌的组织学分型探讨.临床与实验病理学杂志，1998，14：9-12
[3]Bloom H，Richantson W.Histological grading and prognosis in breast can-cer.Br J，cancer,1957,9：359-77
[4]Elston CW,Ellis Io.Pathological prognositic factors in breast cancer.The value of histological grade in breast cancer：experience from a large study with long-term follow-up.Histopathology，1991，19：403-10
, http://www.100md.com
[5]张廷 ，涂小予，徐薇苓，等.乳腺癌组织学分级及预后因素分析.中华病理学杂志，1998，27：405-7
[6]Younes M，Laucirica R.Lack of prognostic significance of histological grade in node-negative invasive breast carcinoma.Clin Cancer Res，1997，3：601-4
[7]Pinder SE.Murray S，Ellis Io，et al.The importance of the histologic grade of invasive breast carcinoma and respoose to chemotherapy.Cancer,1998,83：1529-39
[8]Narita M，Nakao K，Ogino N，et al.Independent prognostic factors in breast cancer patients.Am J Surg，1996，175：73-5
[9]乔思杰，姜红光，杨文起.食管鳞状上皮癌生长方式计量研究.河南肿瘤学杂志，1992,5：22-24
[10]夏旭.体视学理论方法及其在病理学应用的国内进展.医学研究通讯，1996,25：15-18
收稿日期：1999-06-23
修稿日期：1999-11-30, http://www.100md.com
单位：河南省肿瘤医院病理科 郑州 450003
关键词：乳腺肿瘤；体视学；组织学分级；预后
诊断病理学杂志000115摘 要：目的 推荐一个乳腺浸润性导管癌的预后指标一癌巢的表面积密度(Sv)。方法 以Bloom-Richardson和Elston分级法，对343例乳腺浸润性导管癌进行组织学分级并根据体视学原理，采用模板法，测定癌实质体积密度(Vv)及癌巢的表面积密度(Sv)。比较它们与预后的相关性。结果 在与预后有显著相关性的癌组织学分级、癌实质体积密度(Vv)及癌巢的表面积密度(SV)中发现，SV≤4.4的患者中，89.3%生存5年以上，Sv>5.5的患者中，82.5%死于5年以内。结论 癌肿生长方式的体视学参数—Sv是可靠且独立的预后指标，Vv、组织学分级是乳腺浸润性导管癌预后的相关因素。
, 百拇医药
分类号：R737.9 文献标识码：A
文章编号：1007-8096(2000)01-0042-03
Prognostic evaluation of the stereologic parameters of growth pattern and histologic grade in invasive ductal carcinoma of the breast
Pei Suli,Jang Hongguang,Zhao Dongmei
(Department of Pothology, Henan Tumor Hospital,Zhengzhou 450003)
Abstract：Objective To recommend a prognostic factor,surface area density (Sv) of carcinomas nest,in invasive ductal carcinoma(IDC)of the breast. Methods 343 cases of IDC with more than 5 years follow-up wem graded according to the grad-ing systems of Bloom-Richardson and Elston.Their volume density (Vv) of carcinomas parenchyme and surface area density (Sv)of carcinomas nest were measured with stereologic method, and the correlation of the three variables with prognosis were investigat-ed. Results Five-year survival was 89.3% among the patients with Sv≤4.4, where as 82.5% of the patients with Sv>5.5 died within five years. Conclusion Sv is a reliable and independent prognostic factor for patients with breast IDC.
, 百拇医药
Keywords：Breast neoplasm Stereology Histologic grade Prognosis
参考文献：
[1]阙秀.乳腺癌临床病理学.北京：北京医科大学，中国协和医科大学联合出版社，1993.117-127
[2]柳剑英，吕英志，张宏伟，等.乳腺癌的组织学分型探讨.临床与实验病理学杂志，1998，14：9-12
[3]Bloom H，Richantson W.Histological grading and prognosis in breast can-cer.Br J，cancer,1957,9：359-77
[4]Elston CW,Ellis Io.Pathological prognositic factors in breast cancer.The value of histological grade in breast cancer：experience from a large study with long-term follow-up.Histopathology，1991，19：403-10
, http://www.100md.com
[5]张廷 ，涂小予，徐薇苓，等.乳腺癌组织学分级及预后因素分析.中华病理学杂志，1998，27：405-7
[6]Younes M，Laucirica R.Lack of prognostic significance of histological grade in node-negative invasive breast carcinoma.Clin Cancer Res，1997，3：601-4
[7]Pinder SE.Murray S，Ellis Io，et al.The importance of the histologic grade of invasive breast carcinoma and respoose to chemotherapy.Cancer,1998,83：1529-39
[8]Narita M，Nakao K，Ogino N，et al.Independent prognostic factors in breast cancer patients.Am J Surg，1996，175：73-5
[9]乔思杰，姜红光，杨文起.食管鳞状上皮癌生长方式计量研究.河南肿瘤学杂志，1992,5：22-24
[10]夏旭.体视学理论方法及其在病理学应用的国内进展.医学研究通讯，1996,25：15-18
收稿日期：1999-06-23
修稿日期：1999-11-30, http://www.100md.com