特发性血小板减少性紫癜与血小板相关抗体、膜糖蛋白表达的关系
作者：张君丽 俞 康 沈志坚 胡晓霞 王光汉
单位：325000 温州医学院附属第一医院血液科
关键词：血小板减少；特发性血小板减少性紫癜；血小板相关抗体；CD；41a；CD；62p
浙江临床医学000107摘 要：目的：观察ITP患者不同年龄组中PAIg升高的类型及CD41a和CD62p的血小板阳性率和荧光强度。方法：采用ELISA法对220例ITP患者进行PAIgG、M、A测定，其中40例采用流式细胞术测定CD41a和CD62p血小板阳性率及荧光强度。结果：PAIgG、M、A均升高在三组中占大多数，PAIgG、M升高，青中年组高于其它二组，单纯PAIgG升高，儿童组高于其它二组。CD41a和CD62p血小板阳性率及荧光强度，儿童组高于其它二组。CD41a和CD62p双阳性血小板儿童组、青中年组高于老年组。结论：ITP以PAIgG、M、A三者均升高为主要类型，CD41a血小板阳性率及荧光强度在ITP中随着年龄增加而降低，CD62p也有同样的趋势。
, http://www.100md.com
The Relationship of Idiopathic Thrombocytopenia Purpura with Plateletassociated Antibodies and the Expression of Platelet Membrane Glucoprotein
Zhang Junli
Abstract：To observe of the types of increased PAIg, the positive rate and fluorescent intensity of CD 41 a and CD 62 p platelets of different age groups patients with idiopathic thrombocytopenia purpura. Methods: PAIgG, M, A in platelets of 220 cases with ITP were determined by ELISA, and positive rate and fiuopescent intensity CD 41 a and CD 62 p in platelets of 40 cases with ITP were determined by flow cytometry technique. Results: The majority of three group patients have increased PAIgG, M, A. The elevation of PAIgG, M was more common in middle age group than in another two groups, and the elevation of single PAIgG was higer in children gronp than in another two groups. The positive rate and fluorescent intensity CD 41 a and CD 62 p in platelets, the children group was highest in all three groups. The dual positive platelets of both CD 41 a and CD 62 p, which in both the children group and middle age group were higher than in the old age group. Conclusion: All PAIgG, M, A elevation was the predominant type. The positive rate and fluorescent intensity of CD 41 a in platelets with rip was declined with the age elevation. Furthermore, the CD 62 p has the same trends as the CD 41 a.
, 百拇医药
Keywords：Thrombocytopenia ITP PAIg CD 41 a CD 62 p
参考文献：
[1]全国止血与血栓会议关于凝血疾病的诊断标准.中华血液学杂志，1987，8(3)：183.
[2]张源慧.原发性血小板减少性紫癜的发病机理.中华血液学杂志，1990，11(4)：214.
[3]沈志祥，顾荣泉，王鸿利.在血小板减少症中测定血小板表面相关IgG的意义.中华内科杂志，1983，22(4)：222.
[4]Gramen ER，Savidge GF，Vainchenkan W，et al.Alpha—granule pool of glycoprotein Ⅱ b/Ⅲ a in normal and pathologic platelets and megakaryocytes.Blood，1990，75.1220.
[5]黄繁嫱，刘蓉，刘丽，等.健康成人血小板膜糖蛋白的表达特征.中华血液学杂志，1999，20(9)：465., http://www.100md.com
单位：325000 温州医学院附属第一医院血液科
关键词：血小板减少；特发性血小板减少性紫癜；血小板相关抗体；CD；41a；CD；62p
浙江临床医学000107摘 要：目的：观察ITP患者不同年龄组中PAIg升高的类型及CD41a和CD62p的血小板阳性率和荧光强度。方法：采用ELISA法对220例ITP患者进行PAIgG、M、A测定，其中40例采用流式细胞术测定CD41a和CD62p血小板阳性率及荧光强度。结果：PAIgG、M、A均升高在三组中占大多数，PAIgG、M升高，青中年组高于其它二组，单纯PAIgG升高，儿童组高于其它二组。CD41a和CD62p血小板阳性率及荧光强度，儿童组高于其它二组。CD41a和CD62p双阳性血小板儿童组、青中年组高于老年组。结论：ITP以PAIgG、M、A三者均升高为主要类型，CD41a血小板阳性率及荧光强度在ITP中随着年龄增加而降低，CD62p也有同样的趋势。
, http://www.100md.com
The Relationship of Idiopathic Thrombocytopenia Purpura with Plateletassociated Antibodies and the Expression of Platelet Membrane Glucoprotein
Zhang Junli
Abstract：To observe of the types of increased PAIg, the positive rate and fluorescent intensity of CD 41 a and CD 62 p platelets of different age groups patients with idiopathic thrombocytopenia purpura. Methods: PAIgG, M, A in platelets of 220 cases with ITP were determined by ELISA, and positive rate and fiuopescent intensity CD 41 a and CD 62 p in platelets of 40 cases with ITP were determined by flow cytometry technique. Results: The majority of three group patients have increased PAIgG, M, A. The elevation of PAIgG, M was more common in middle age group than in another two groups, and the elevation of single PAIgG was higer in children gronp than in another two groups. The positive rate and fluorescent intensity CD 41 a and CD 62 p in platelets, the children group was highest in all three groups. The dual positive platelets of both CD 41 a and CD 62 p, which in both the children group and middle age group were higher than in the old age group. Conclusion: All PAIgG, M, A elevation was the predominant type. The positive rate and fluorescent intensity of CD 41 a in platelets with rip was declined with the age elevation. Furthermore, the CD 62 p has the same trends as the CD 41 a.
, 百拇医药
Keywords：Thrombocytopenia ITP PAIg CD 41 a CD 62 p
参考文献：
[1]全国止血与血栓会议关于凝血疾病的诊断标准.中华血液学杂志，1987，8(3)：183.
[2]张源慧.原发性血小板减少性紫癜的发病机理.中华血液学杂志，1990，11(4)：214.
[3]沈志祥，顾荣泉，王鸿利.在血小板减少症中测定血小板表面相关IgG的意义.中华内科杂志，1983，22(4)：222.
[4]Gramen ER，Savidge GF，Vainchenkan W，et al.Alpha—granule pool of glycoprotein Ⅱ b/Ⅲ a in normal and pathologic platelets and megakaryocytes.Blood，1990，75.1220.
[5]黄繁嫱，刘蓉，刘丽，等.健康成人血小板膜糖蛋白的表达特征.中华血液学杂志，1999，20(9)：465., http://www.100md.com