IgG、C3在莱姆病皮肤慢性游走性红斑病变中的表达
作者：安京媛 吴霞 周国萍 艾承绪 王美娥 潘惠娟
单位：吴霞 周国萍(北京军区总医院)；艾承绪(解放军总医院)；安京媛 王美娥 潘惠娟(武警总医院病理科 100039)
关键词：IgG；C3；莱姆病；慢性游走性红班
诊断病理学杂志000114摘 要：目的 探讨IgG、C3在莱姆病皮肤慢性游走性红斑病变中的分布和表达。方法 应用微波免疫组化S-P法检测了9例莱姆病和临床疑诊为莱姆病患者的皮肤慢性游走性红斑病变组织，观察病变组织中IgG和C3的表达并与正常人皮肤组织对照。结果 研究发现IgG和C3阳性表达的强度以及分布范围在病变组织角质层和颗粒层较显著。4例莱姆病患者血清学检查、病变组织硝酸银染色、IgG、C3免疫组化染色结果均呈阳性。结论 IgG、C3在莱姆病皮肤慢性游走性红班病变中的表达与慢性游走性红班的形成相关。
分类号：R758.62 文献标识码：A
文章编号：1007-8096(2000)01-0039-03
Expression of IgG and C3 in skin lesions of erythema chromicum migrans in Lyme' s disease
An Jingyuan,Wu Xia,Zhou Guoping
(General Hospital of the Armed Police, Beijing 100039)
Abstract：Object To study the expression and distribution of IgG and C3 in skin lesions of erythema chromicum migrans in Lyme's disease. Method Nine bioptic skin specimens of clinically diagnosed and suspected Lyme's disease were examined with the S-P method of immunohistochemical staining to detect the presence of IgG and C3. Four specimens of normal skin were used as controls. Result IgG and C3 were positively stained in all the specimens examined. Conclusion Formation of ery-thema chromicum migrans is associated with the expression of IgG and C3.
Keywords：IgG C3 Lyme's disease Erythema chromicum migrans
参考文献：
[1]Rahn DW，Malawista SE.Lyme disease：Recommendations for Diagnosis and treatment.Ann Intern Med，1991，114：472-81
[2]安京嫒，马述仕，王美娥，等.实验性家兔莱姆病病理形态学观察.中华病理学杂志，1993，3：183
[3]Hardin JA，Steere AC，Malanista SE.Immune Complexes and the evolution of lyme arthritis.N Engl J Med，1979，301：1358-63
[4]旋玉英，王景昭.Lyme病.国外医学眼科分册，1991，3：137-139
[5]Blaauw I，Ndhlmans L.Diagnostic tools in Lyoue brreliosis：clinical history compared with serology.J Clin Epidemiol，1992,45：1229-36
[6]李影林主编.临床微生物学及检验.北京：人民卫生出版社，1995.473
[7]张薇芬，周国萍，冯方波，等.从1例白瘢风患者血液中分离出莱姆病病原体.中华医学检验杂志，1992,2：94-96
收稿日期：1999-02-25
修稿日期：1999-07-12, http://www.100md.com
单位：吴霞 周国萍(北京军区总医院)；艾承绪(解放军总医院)；安京媛 王美娥 潘惠娟(武警总医院病理科 100039)
关键词：IgG；C3；莱姆病；慢性游走性红班
诊断病理学杂志000114摘 要：目的 探讨IgG、C3在莱姆病皮肤慢性游走性红斑病变中的分布和表达。方法 应用微波免疫组化S-P法检测了9例莱姆病和临床疑诊为莱姆病患者的皮肤慢性游走性红斑病变组织，观察病变组织中IgG和C3的表达并与正常人皮肤组织对照。结果 研究发现IgG和C3阳性表达的强度以及分布范围在病变组织角质层和颗粒层较显著。4例莱姆病患者血清学检查、病变组织硝酸银染色、IgG、C3免疫组化染色结果均呈阳性。结论 IgG、C3在莱姆病皮肤慢性游走性红班病变中的表达与慢性游走性红班的形成相关。
分类号：R758.62 文献标识码：A
文章编号：1007-8096(2000)01-0039-03
Expression of IgG and C3 in skin lesions of erythema chromicum migrans in Lyme' s disease
An Jingyuan,Wu Xia,Zhou Guoping
(General Hospital of the Armed Police, Beijing 100039)
Abstract：Object To study the expression and distribution of IgG and C3 in skin lesions of erythema chromicum migrans in Lyme's disease. Method Nine bioptic skin specimens of clinically diagnosed and suspected Lyme's disease were examined with the S-P method of immunohistochemical staining to detect the presence of IgG and C3. Four specimens of normal skin were used as controls. Result IgG and C3 were positively stained in all the specimens examined. Conclusion Formation of ery-thema chromicum migrans is associated with the expression of IgG and C3.
Keywords：IgG C3 Lyme's disease Erythema chromicum migrans
参考文献：
[1]Rahn DW，Malawista SE.Lyme disease：Recommendations for Diagnosis and treatment.Ann Intern Med，1991，114：472-81
[2]安京嫒，马述仕，王美娥，等.实验性家兔莱姆病病理形态学观察.中华病理学杂志，1993，3：183
[3]Hardin JA，Steere AC，Malanista SE.Immune Complexes and the evolution of lyme arthritis.N Engl J Med，1979，301：1358-63
[4]旋玉英，王景昭.Lyme病.国外医学眼科分册，1991，3：137-139
[5]Blaauw I，Ndhlmans L.Diagnostic tools in Lyoue brreliosis：clinical history compared with serology.J Clin Epidemiol，1992,45：1229-36
[6]李影林主编.临床微生物学及检验.北京：人民卫生出版社，1995.473
[7]张薇芬，周国萍，冯方波，等.从1例白瘢风患者血液中分离出莱姆病病原体.中华医学检验杂志，1992,2：94-96
收稿日期：1999-02-25
修稿日期：1999-07-12, http://www.100md.com