层粘连蛋白和纤维粘连蛋白在正常绒毛膜组织中的表达
作者：王强 高英茂 张金萍
单位：山东医科大学组织学与胚胎学教研室 济南 250012
关键词：
解剖科学进展000303摘 要：层粘连蛋白和纤维粘连蛋白是细胞外基质的重要成分，在正常组织中有广泛分布。 目前认为层粘连蛋白有10条不同源的多肽链，构成11种不同的蛋白分子。纤维粘连蛋白的结构具有多形性，主要由ED-A、ED-B、Ⅲ CS三个结构区不同的拼接方式所决定。层粘连蛋白和纤维粘连蛋白不仅在支持、连接和维持组织形态，调节细胞的粘附、生长、分化、增殖等方面起重要作用，而且与胚泡着床及胎盘的形成也有密切关系。
参考文献：
[1]David L, Nesland JM, Holm, et al. Expression of laminin, collagen N, fibronectin, and type Ⅳ collagenase in gastic carcinoma. Cancer, 1994, 73: 518
, http://www.100md.com
[2]Pellegrini R, Martignone S, Tagliabue E, et al. Prognostic significance of laminin production in relation with its receptor expression in human breast carcinoma. Breast Cancer Res Treat, 1995, 35: 195
[3]Korhonen M, Virtanen I. The distribution of laminin and fibronectin is medulated during extravillous trophoblastic cell differentiation and decidual cell response to invasion in the human placenta. J Histochem Cytochem, 1997, 45: 569
, 百拇医药
[4]Huppertz B, Kertachanska S, Frank HG, et al. Extracellular matrix components of the placental extravillous trophoblast:immunocytochemistry and ultrastructural distribution. Histochem Cell Bio1, 1996, 106: 291
[5]Charpin C, Kopp F, Pourrean-Schneider N, et al. Laminin distribution in human decidue and immature placenta. Am J Obstel Gynecol, 1985, 151: 822
[6]Church HJ, Aplin JD. Bewo choriocarcinoma cells produce laminin 10. Biochem J, 1998, 332: 491
, 百拇医药
[7]Cioce V, Castronovo V, Shmookler BM, et al. Incresed expression of the laminin recepter in human colon cancer. J Natl Cancer lnst, 1991, 83: 29
[8]Ffrench-Constant C. Alternative splicing of fibronectin-many different proteins but few different functions. Exp Cell Res, 1995, 221: 261
[9]Iwahashi M, Mursgaki Y, Ooshima A, et al. Increased laminin 1 expression in hydatidiform mole. Mol Hum Reprod, 1997, 3: 1107
, 百拇医药
[10]Yamaguchi Y, Isemura M, Yosizawa Z, et al. Changes in the distribution of fibroenction in the palcenta during normal human pregnancy. Am J Obstet Gynecol, 1985, 152, 715
[11]Emonard H, Christiane Y, Smet M, et al. Type Ⅳ and interstitial collagenolytic activities in normal and malignant trophoblastic cells are specifically regulated by the extracellular matrix. Invasion Metastasis, 1990, 10: 170
[12]Clark EA, Brugge JS. Integrins and signal transdution pathways, the road taken. Science, 1995, 268: 233
, http://www.100md.com
[13]Yudoh K, Matsui H, Kanamoric M, et al. Tumor cell attachment to laminin promotes degredation of the extracellular matrix and cell migration in high-matastatic clone cells of RcT sarcoma in vitro. Jpn J Cancer Res, 1995, 86: 685
[14]Kleinman HK, Kibberg MC, Schnaper HW, et al. In, Rohrbach DH eds. Molecular and cellular aspects of basement membranes. San Diego CA: Academic Press, 1993, 309
[15]Damsky CH, Librach C, Lim KH, et al. Integrin switching regulates normal trophoblast invasion. Development, 1994, 120: 3657
[16]Aplin JD. Expression of integrin α6β4 in human trophoblast and its loss from extrsvillous cells. Placenta, 1993, 14: 203, 百拇医药
单位：山东医科大学组织学与胚胎学教研室 济南 250012
关键词：
解剖科学进展000303摘 要：层粘连蛋白和纤维粘连蛋白是细胞外基质的重要成分，在正常组织中有广泛分布。 目前认为层粘连蛋白有10条不同源的多肽链，构成11种不同的蛋白分子。纤维粘连蛋白的结构具有多形性，主要由ED-A、ED-B、Ⅲ CS三个结构区不同的拼接方式所决定。层粘连蛋白和纤维粘连蛋白不仅在支持、连接和维持组织形态，调节细胞的粘附、生长、分化、增殖等方面起重要作用，而且与胚泡着床及胎盘的形成也有密切关系。
参考文献：
[1]David L, Nesland JM, Holm, et al. Expression of laminin, collagen N, fibronectin, and type Ⅳ collagenase in gastic carcinoma. Cancer, 1994, 73: 518
, http://www.100md.com
[2]Pellegrini R, Martignone S, Tagliabue E, et al. Prognostic significance of laminin production in relation with its receptor expression in human breast carcinoma. Breast Cancer Res Treat, 1995, 35: 195
[3]Korhonen M, Virtanen I. The distribution of laminin and fibronectin is medulated during extravillous trophoblastic cell differentiation and decidual cell response to invasion in the human placenta. J Histochem Cytochem, 1997, 45: 569
, 百拇医药
[4]Huppertz B, Kertachanska S, Frank HG, et al. Extracellular matrix components of the placental extravillous trophoblast:immunocytochemistry and ultrastructural distribution. Histochem Cell Bio1, 1996, 106: 291
[5]Charpin C, Kopp F, Pourrean-Schneider N, et al. Laminin distribution in human decidue and immature placenta. Am J Obstel Gynecol, 1985, 151: 822
[6]Church HJ, Aplin JD. Bewo choriocarcinoma cells produce laminin 10. Biochem J, 1998, 332: 491
, 百拇医药
[7]Cioce V, Castronovo V, Shmookler BM, et al. Incresed expression of the laminin recepter in human colon cancer. J Natl Cancer lnst, 1991, 83: 29
[8]Ffrench-Constant C. Alternative splicing of fibronectin-many different proteins but few different functions. Exp Cell Res, 1995, 221: 261
[9]Iwahashi M, Mursgaki Y, Ooshima A, et al. Increased laminin 1 expression in hydatidiform mole. Mol Hum Reprod, 1997, 3: 1107
, 百拇医药
[10]Yamaguchi Y, Isemura M, Yosizawa Z, et al. Changes in the distribution of fibroenction in the palcenta during normal human pregnancy. Am J Obstet Gynecol, 1985, 152, 715
[11]Emonard H, Christiane Y, Smet M, et al. Type Ⅳ and interstitial collagenolytic activities in normal and malignant trophoblastic cells are specifically regulated by the extracellular matrix. Invasion Metastasis, 1990, 10: 170
[12]Clark EA, Brugge JS. Integrins and signal transdution pathways, the road taken. Science, 1995, 268: 233
, http://www.100md.com
[13]Yudoh K, Matsui H, Kanamoric M, et al. Tumor cell attachment to laminin promotes degredation of the extracellular matrix and cell migration in high-matastatic clone cells of RcT sarcoma in vitro. Jpn J Cancer Res, 1995, 86: 685
[14]Kleinman HK, Kibberg MC, Schnaper HW, et al. In, Rohrbach DH eds. Molecular and cellular aspects of basement membranes. San Diego CA: Academic Press, 1993, 309
[15]Damsky CH, Librach C, Lim KH, et al. Integrin switching regulates normal trophoblast invasion. Development, 1994, 120: 3657
[16]Aplin JD. Expression of integrin α6β4 in human trophoblast and its loss from extrsvillous cells. Placenta, 1993, 14: 203, 百拇医药