从辽东木根皮中分得的两个新皂苷
作者：宋少江 李劲鸿 徐绥绪 路金才 服部征雄
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中国药物化学杂志000421 Two New Saponins from the Root Bark of Aralia elata
Song Shaojiang，Xu Suixu，Lu Jincai，Hattori Masao
(Department of Traditional Chinese Medicines of Shenyang Pharmaceutical University,Shenyang,110015)
Li Jinhong
, http://www.100md.com (Department of Pharmacy of the Central Hospital of Tieling,Tieling 112000)
Abstract Two new saponins,3-O-{〔β-D-glucopyranosyl (1→2)〕-〔β-D-glucopyranosyl (1→3)-β-D-glucopyranosyl (1→3)〕-β-D-glucopyranosyl} oleanolic acid 28-O-β-D-glucopyranosyl ester，(congmunoside Ⅹ，1)；3-O-{〔β-D-glucopyranosyl (1→3)〕-〔α-L-arabinofuranosyl (1→4)〕-β-D-glucuronopyranosyl} oleanolic acid 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside，(congmunoside Ⅺ，2)were isolated from the root bark of Aralia elata(Miq.)Seem.Their structures were determined on the basis of the chemical and spectroscopy methods.
, 百拇医药
Key words Aralia elata(Miq.)Seem.;oleanolic acid;triterpenoid saponin;congmunoside Ⅹ;congmunoside Ⅺ
从辽东木Aralia elata(Miq.)Seem根皮中分离得到两个新的三萜皂苷，通过理化和谱学分析(MS，NMR)，确定结构分别为3-O-{〔β-D-glucopyranosyl(1→2)〕-〔β-D-glucopyranosyl(1→3)-β-D-glucopyranosyl(1→3)〕-β-D-glucopyranosyl}oleanolic acid 28-O-β-D-glucopyranosyl ester，命名为辽东木皂苷Ⅹ(congmunoside Ⅹ，见图1)；3-O-{〔β-D-glucopyranosyl(1→3)〕-〔α-L-arabinofuranosyl(1→4)〕-β-D-glucuronopyranosyl}oleanolic acid 28-O-β-D-glucopyranosyl-(16)-β-D-glucopyranoside，命名为辽东木皂苷Ⅺ(congmunoside Ⅺ，见图2).
, http://www.100md.com
Fig.1 Congmunoside Ⅹ
Fig.2 Congmunoside Ⅺ
辽东木皂苷Ⅹ为白色无定形粉末，Liebermann-Burchard反应和Molish反应均为阳性.酸水解只检出葡萄糖.HR-FABMS给出分子式为C60H98O28(观察值 m/z:1289.6163〔M+Na〕+；计算值C60H98O28Na:1289.6172).正ESI-MS给出准分子离子峰m/z：1289〔M+Na〕+,负ESI-MS给出准分子离子峰m/z：1265〔M-H〕-，1103〔M-H-glc〕-，941〔M-H-2glc〕-,779〔M-H-3glc〕-，617〔M-H-4glc〕-,455〔M-H-5glc〕-.结合其核磁共振谱(1H-NMR,13C-NMR,1H-1H COSY,TOCSY,HMQC,HMBC)数据的分析，辽东木皂苷Ⅹ的结构如图1所示.
, 百拇医药
辽东木皂苷Ⅺ为白色无定形粉末，Liebermann-Burchard反应和Molish反应均为阳性.酸水解检出葡萄糖醛酸、阿拉伯糖和葡萄糖.HR-FABMS给出分子式为C59H93O28(观察值 m/z:1249.5874〔M-H〕-；计算值C59H93O28:1249.5868).正ESI-MS给出准分子离子峰m/z：1273〔M+Na〕-及1111〔M+Na-glc〕-，949〔M+Na-2glc〕-，787〔M+Na-3glc〕-，655〔M+Na-3glc-ara〕-；负ESI-MS给出准分子离子峰m/z：1249〔M-H〕-.结合其核磁共振谱(1H-NMR，13C-NMR，1H-1H COSY，TOCSY，HMQC，HMBC)数据的分析，辽东木皂苷Ⅺ的结构如图2所示.
, 百拇医药
宋少江(沈阳药科大学中药系，沈阳 110015)
李劲鸿(铁岭市中心医院制剂室，112000)
徐绥绪(沈阳药科大学中药系，沈阳 110015)
路金才(沈阳药科大学中药系，沈阳 110015)
服部征雄(富山医科药科大学和汉药物研究所，日本国富山县富山市杉谷2630，930-0194)
参 考 文 献
1，江苏新医学院编.中药大辞典.上海:上海人民出版社,1977.2583
2，姜永涛,徐绥绪,顾晓华,等.辽东木化学成分的研究.药学学报,1992，27(7):528～532
3，MeiHu,Ogawa K,Sashida Y,et al.Triterpenoid glucuronide saponins from root bark of Aralia armata.Phytochemistry,1995,39(1):179～184
收稿日期:2000-07-11, http://www.100md.com
单位：
关键词：
中国药物化学杂志000421 Two New Saponins from the Root Bark of Aralia elata
Song Shaojiang，Xu Suixu，Lu Jincai，Hattori Masao
(Department of Traditional Chinese Medicines of Shenyang Pharmaceutical University,Shenyang,110015)
Li Jinhong
, http://www.100md.com (Department of Pharmacy of the Central Hospital of Tieling,Tieling 112000)
Abstract Two new saponins,3-O-{〔β-D-glucopyranosyl (1→2)〕-〔β-D-glucopyranosyl (1→3)-β-D-glucopyranosyl (1→3)〕-β-D-glucopyranosyl} oleanolic acid 28-O-β-D-glucopyranosyl ester，(congmunoside Ⅹ，1)；3-O-{〔β-D-glucopyranosyl (1→3)〕-〔α-L-arabinofuranosyl (1→4)〕-β-D-glucuronopyranosyl} oleanolic acid 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside，(congmunoside Ⅺ，2)were isolated from the root bark of Aralia elata(Miq.)Seem.Their structures were determined on the basis of the chemical and spectroscopy methods.
, 百拇医药
Key words Aralia elata(Miq.)Seem.;oleanolic acid;triterpenoid saponin;congmunoside Ⅹ;congmunoside Ⅺ
从辽东木Aralia elata(Miq.)Seem根皮中分离得到两个新的三萜皂苷，通过理化和谱学分析(MS，NMR)，确定结构分别为3-O-{〔β-D-glucopyranosyl(1→2)〕-〔β-D-glucopyranosyl(1→3)-β-D-glucopyranosyl(1→3)〕-β-D-glucopyranosyl}oleanolic acid 28-O-β-D-glucopyranosyl ester，命名为辽东木皂苷Ⅹ(congmunoside Ⅹ，见图1)；3-O-{〔β-D-glucopyranosyl(1→3)〕-〔α-L-arabinofuranosyl(1→4)〕-β-D-glucuronopyranosyl}oleanolic acid 28-O-β-D-glucopyranosyl-(16)-β-D-glucopyranoside，命名为辽东木皂苷Ⅺ(congmunoside Ⅺ，见图2).
, http://www.100md.com
Fig.1 Congmunoside Ⅹ
Fig.2 Congmunoside Ⅺ
辽东木皂苷Ⅹ为白色无定形粉末，Liebermann-Burchard反应和Molish反应均为阳性.酸水解只检出葡萄糖.HR-FABMS给出分子式为C60H98O28(观察值 m/z:1289.6163〔M+Na〕+；计算值C60H98O28Na:1289.6172).正ESI-MS给出准分子离子峰m/z：1289〔M+Na〕+,负ESI-MS给出准分子离子峰m/z：1265〔M-H〕-，1103〔M-H-glc〕-，941〔M-H-2glc〕-,779〔M-H-3glc〕-，617〔M-H-4glc〕-,455〔M-H-5glc〕-.结合其核磁共振谱(1H-NMR,13C-NMR,1H-1H COSY,TOCSY,HMQC,HMBC)数据的分析，辽东木皂苷Ⅹ的结构如图1所示.
, 百拇医药
辽东木皂苷Ⅺ为白色无定形粉末，Liebermann-Burchard反应和Molish反应均为阳性.酸水解检出葡萄糖醛酸、阿拉伯糖和葡萄糖.HR-FABMS给出分子式为C59H93O28(观察值 m/z:1249.5874〔M-H〕-；计算值C59H93O28:1249.5868).正ESI-MS给出准分子离子峰m/z：1273〔M+Na〕-及1111〔M+Na-glc〕-，949〔M+Na-2glc〕-，787〔M+Na-3glc〕-，655〔M+Na-3glc-ara〕-；负ESI-MS给出准分子离子峰m/z：1249〔M-H〕-.结合其核磁共振谱(1H-NMR，13C-NMR，1H-1H COSY，TOCSY，HMQC，HMBC)数据的分析，辽东木皂苷Ⅺ的结构如图2所示.
, 百拇医药
宋少江(沈阳药科大学中药系，沈阳 110015)
李劲鸿(铁岭市中心医院制剂室，112000)
徐绥绪(沈阳药科大学中药系，沈阳 110015)
路金才(沈阳药科大学中药系，沈阳 110015)
服部征雄(富山医科药科大学和汉药物研究所，日本国富山县富山市杉谷2630，930-0194)
参 考 文 献
1，江苏新医学院编.中药大辞典.上海:上海人民出版社,1977.2583
2，姜永涛,徐绥绪,顾晓华,等.辽东木化学成分的研究.药学学报,1992，27(7):528～532
3，MeiHu,Ogawa K,Sashida Y,et al.Triterpenoid glucuronide saponins from root bark of Aralia armata.Phytochemistry,1995,39(1):179～184
收稿日期:2000-07-11, http://www.100md.com