524例IgA肾病的临床与病理分析
作者：郝翠兰 陈瑾君 张慧新 盛征 俞建民 储谦
单位：郝翠兰 盛征 俞建民 储谦(200025 上海第二医科大学附属瑞金医院肾内科) ;陈瑾君(上海第二医科大学附属第九人民医院肾内科);张慧新(上海第二医科大学电镜室)
关键词：IgA肾病；病理学；临床
中华肾脏病杂志000512摘 要：目的回顾性地总结我科10多年来所积累的IgA肾病资料，包括各年龄组的发病率、临床、病理特点及其相关性。方法524例IgA肾病按照年龄分成3组，根据各年龄组的临床及其组织学特点进行分析。结果少儿组复发性肉眼血尿发生率最高为47.2%，慢性肾损害为4.6%。青壮年组恶性高血压的发生率为3.8%，也称为恶性IgA肾病。老年组肾病综合征和急性肾功能衰竭的发生率高于上述两组。结论随着肾活检的广泛开展，少儿和老年的IgA肾病的发生率也增加，尤其是少儿，必须加强对他们的随访。老年人疑为IgA肾病者，必须及时肾活检。青壮年IgA肾病仍然占大部分比例。
, 百拇医药
Clinical presentation and pathologic feature of 524 patients with IgA nephropathy
HAO Cuilan ,CHEN Jinjun ,ZHANG Huixin,et al.
(Department of Nephrology,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China)
Abstract：Objective To analyse the incidence,clinical features,histopathology and clinicopathological correlation in different age group of 524 cases with IgA nephropathy (IgAN) retrospectively.Methods 524 cases of IgA nephropathy were divided into three groups according to their age,and the clinical and renal pathological features were analyzed.Results In children group(≤15 years),the incidence of recurrent gross hematuria was 47.2% and renal impairment 4.6%.Malignant hypertension as first presentation associated with serious renal impairment occurred in 3.8% patients of youth and adult group(16～49 years).Higher incidence of nephrotic syndrome and acute renal failure was found in elder group (50～69 years).Conclusions The incidence of IgAN in children and elder population is increased,especially in the children.They need a further follow-up.For elder patients considered as IgAN,a renal biopsy seems to be necessary.While youths and adults still account for the most part of IgAN patients.
, 百拇医药
Keywords：IgA nephropathy;Pathology;Clinic
参考文献：
[1]D’Amico G.The commonest glomerulonephritis in the world:IgA nephropathy.Q J Med,1987,245:709-727.
[2]van Es,LA.Pathogenesis of IgA Ncphropathy.Nephrology,1997,3:13-17.
[3]Levy M,Berger J.Worldwide perspective of IgA nephropathy.Am J Kidney Dis,1988,12:340-347.
[4]Berger J.Long term follow up of renal function in IgA nephropathy.Arch Disease Childhood,1991,66:588-592.
, 百拇医药
[5]Alamartine E,Sabatier JC,Guerin C,et al.Prognostic factors in mesangial IgA glomerulonephritis:an extensive study with univariate and multivariate analyses.Am J Kidney Dis,1991,18:12-19.
[6]D＇Amico G.Epidemiological clinical and prognostic indices in IgA nephropathy.Nephrology,1997,3:41-44.
[7]Levy M,Lesavre P.Genetic factors in IgA nephropathy(Berger’s disease).Adv Nephrol,1992,21:23-49.
[8]Nicholls KM,Fairley KF,Dowling JP,et al.The clinical course of mesangial IgA associated nephropathy in adults.Q J Med,1984,210:227-250.
[9]NCT Kong.IgA nephropathy:a vasculitis?Nephrology,1997,3:23-26.
收稿日期：2000-02-05, http://www.100md.com
单位：郝翠兰 盛征 俞建民 储谦(200025 上海第二医科大学附属瑞金医院肾内科) ;陈瑾君(上海第二医科大学附属第九人民医院肾内科);张慧新(上海第二医科大学电镜室)
关键词：IgA肾病；病理学；临床
中华肾脏病杂志000512摘 要：目的回顾性地总结我科10多年来所积累的IgA肾病资料，包括各年龄组的发病率、临床、病理特点及其相关性。方法524例IgA肾病按照年龄分成3组，根据各年龄组的临床及其组织学特点进行分析。结果少儿组复发性肉眼血尿发生率最高为47.2%，慢性肾损害为4.6%。青壮年组恶性高血压的发生率为3.8%，也称为恶性IgA肾病。老年组肾病综合征和急性肾功能衰竭的发生率高于上述两组。结论随着肾活检的广泛开展，少儿和老年的IgA肾病的发生率也增加，尤其是少儿，必须加强对他们的随访。老年人疑为IgA肾病者，必须及时肾活检。青壮年IgA肾病仍然占大部分比例。
, 百拇医药
Clinical presentation and pathologic feature of 524 patients with IgA nephropathy
HAO Cuilan ,CHEN Jinjun ,ZHANG Huixin,et al.
(Department of Nephrology,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China)
Abstract：Objective To analyse the incidence,clinical features,histopathology and clinicopathological correlation in different age group of 524 cases with IgA nephropathy (IgAN) retrospectively.Methods 524 cases of IgA nephropathy were divided into three groups according to their age,and the clinical and renal pathological features were analyzed.Results In children group(≤15 years),the incidence of recurrent gross hematuria was 47.2% and renal impairment 4.6%.Malignant hypertension as first presentation associated with serious renal impairment occurred in 3.8% patients of youth and adult group(16～49 years).Higher incidence of nephrotic syndrome and acute renal failure was found in elder group (50～69 years).Conclusions The incidence of IgAN in children and elder population is increased,especially in the children.They need a further follow-up.For elder patients considered as IgAN,a renal biopsy seems to be necessary.While youths and adults still account for the most part of IgAN patients.
, 百拇医药
Keywords：IgA nephropathy;Pathology;Clinic
参考文献：
[1]D’Amico G.The commonest glomerulonephritis in the world:IgA nephropathy.Q J Med,1987,245:709-727.
[2]van Es,LA.Pathogenesis of IgA Ncphropathy.Nephrology,1997,3:13-17.
[3]Levy M,Berger J.Worldwide perspective of IgA nephropathy.Am J Kidney Dis,1988,12:340-347.
[4]Berger J.Long term follow up of renal function in IgA nephropathy.Arch Disease Childhood,1991,66:588-592.
, 百拇医药
[5]Alamartine E,Sabatier JC,Guerin C,et al.Prognostic factors in mesangial IgA glomerulonephritis:an extensive study with univariate and multivariate analyses.Am J Kidney Dis,1991,18:12-19.
[6]D＇Amico G.Epidemiological clinical and prognostic indices in IgA nephropathy.Nephrology,1997,3:41-44.
[7]Levy M,Lesavre P.Genetic factors in IgA nephropathy(Berger’s disease).Adv Nephrol,1992,21:23-49.
[8]Nicholls KM,Fairley KF,Dowling JP,et al.The clinical course of mesangial IgA associated nephropathy in adults.Q J Med,1984,210:227-250.
[9]NCT Kong.IgA nephropathy:a vasculitis?Nephrology,1997,3:23-26.
收稿日期：2000-02-05, http://www.100md.com