CEA、CA－50检测对恶性胸水诊断价值探讨
作者：高中度 袁维祥 茅爱武 王敏 蒋廷辉
单位：200050 上海市，上海同仁医院
关键词：肿瘤相关抗原；CEA、CA-50；胸腔积液
中国煤炭工业医学杂志000972 摘 要：目的为寻求简便有效的方法对良恶性胸水进行鉴别诊断。方法采用放射免疫分析技术对健康对照组30例、已确诊的恶性胸水组15例、良性胸水组33例血清及胸水进行CEA、CA-50平行对照检。结果恶性胸水组血清及胸水CEA、CA-50水平显著高于良性胸水组。结论提示对胸水进行CEA、CA-50检测有利于良恶性胸水鉴别诊断，且CEA、CA-50联合检测可提高恶性胸水诊断阳性率。
STUDY ON CEA AND CA-50 RADIOIMMUNOASSAY FOR THE DIAGNOSIS OF MALIGNANT HYDROTHORAX
Gao Zhongdu ,Yuan Weixiang ,Mao Aiwu
(Shanghai St. Luke's Hospital, Shanghai 200050)
Abstract：Objective To find an easy and effective method for the differential diagnosis between benign and malignant hyolrothorax. Methods Radioimmunoassay technique was used. CA-50 level and CEA level of serum and by_ drothorax were determined in 15 patients with malignant hydrothorax and in 33 patients with benign hydrothorax, and in 30 healthy persons as control. Results The CA-50 level and CEA level of serum and hydrothorax in malignant hydothorax were significantly higher than those in benign hydrothorax (P<0. 01). Conclusion Hydrothorax CA-50 and CEA determination are effective for differential diagnosis between benign and malignant hydrothoraxes. The positive diagnostic ratejof malignant hydrothorax will be increased when combined determination of CA-50 and CEA is used.
Keywords：Tumor associated antigen CEA, CA-50 Pleural effusion
参考文献：
[1]杜娟，蒋宁一，凌铁如，等.CA-50 IRMA在肿瘤诊断中应用及与CEA对照分析.放射免疫学杂志，1992，5(1)：8.
[2]王楫裴.CEA RIA在恶性肿瘤诊断中的应用.放射免疫学杂志，1992，5(1)：10.
[3]刘家琴，王自正，陆雪龙.支气管肺泡灌洗液CEA和CA-50测定对肺癌的诊断价值.放射免疫学杂志，1995，8(3)：144.
[4]陈智国，范振符，许建衡，等.肿瘤相关抗原CA-50的免疫放射分析.中国医学科学院学报，1998，10(4)；262.
[5]尹伯元.放射免疫分析在医学中的应用.北京：原子能出版社，1992.318-326.
[6]Holmgren J，Lindholm L，Persson B，et al.Detection by monoclonalantibody of carbohydrate antigen cA-50 in serum of patients with carcinoma.British Med J，1984，288:1479.
[7]杜同信，王自正，时宏珍，等.CEA、SA、CAl25、SF、β2-m联检对肺癌的诊断价值.放射免疫学杂志，1995，8(3)：146.
收稿日期：2000-01-25
修稿日期：2000-06-19, http://www.100md.com
单位：200050 上海市，上海同仁医院
关键词：肿瘤相关抗原；CEA、CA-50；胸腔积液
中国煤炭工业医学杂志000972 摘 要：目的为寻求简便有效的方法对良恶性胸水进行鉴别诊断。方法采用放射免疫分析技术对健康对照组30例、已确诊的恶性胸水组15例、良性胸水组33例血清及胸水进行CEA、CA-50平行对照检。结果恶性胸水组血清及胸水CEA、CA-50水平显著高于良性胸水组。结论提示对胸水进行CEA、CA-50检测有利于良恶性胸水鉴别诊断，且CEA、CA-50联合检测可提高恶性胸水诊断阳性率。
STUDY ON CEA AND CA-50 RADIOIMMUNOASSAY FOR THE DIAGNOSIS OF MALIGNANT HYDROTHORAX
Gao Zhongdu ,Yuan Weixiang ,Mao Aiwu
(Shanghai St. Luke's Hospital, Shanghai 200050)
Abstract：Objective To find an easy and effective method for the differential diagnosis between benign and malignant hyolrothorax. Methods Radioimmunoassay technique was used. CA-50 level and CEA level of serum and by_ drothorax were determined in 15 patients with malignant hydrothorax and in 33 patients with benign hydrothorax, and in 30 healthy persons as control. Results The CA-50 level and CEA level of serum and hydrothorax in malignant hydothorax were significantly higher than those in benign hydrothorax (P<0. 01). Conclusion Hydrothorax CA-50 and CEA determination are effective for differential diagnosis between benign and malignant hydrothoraxes. The positive diagnostic ratejof malignant hydrothorax will be increased when combined determination of CA-50 and CEA is used.
Keywords：Tumor associated antigen CEA, CA-50 Pleural effusion
参考文献：
[1]杜娟，蒋宁一，凌铁如，等.CA-50 IRMA在肿瘤诊断中应用及与CEA对照分析.放射免疫学杂志，1992，5(1)：8.
[2]王楫裴.CEA RIA在恶性肿瘤诊断中的应用.放射免疫学杂志，1992，5(1)：10.
[3]刘家琴，王自正，陆雪龙.支气管肺泡灌洗液CEA和CA-50测定对肺癌的诊断价值.放射免疫学杂志，1995，8(3)：144.
[4]陈智国，范振符，许建衡，等.肿瘤相关抗原CA-50的免疫放射分析.中国医学科学院学报，1998，10(4)；262.
[5]尹伯元.放射免疫分析在医学中的应用.北京：原子能出版社，1992.318-326.
[6]Holmgren J，Lindholm L，Persson B，et al.Detection by monoclonalantibody of carbohydrate antigen cA-50 in serum of patients with carcinoma.British Med J，1984，288:1479.
[7]杜同信，王自正，时宏珍，等.CEA、SA、CAl25、SF、β2-m联检对肺癌的诊断价值.放射免疫学杂志，1995，8(3)：146.
收稿日期：2000-01-25
修稿日期：2000-06-19, http://www.100md.com