Construction and Analysis of a Human-Chimpanzee Comparative Clone Map
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Asao Fujiyama；Hidemi Watanabe；Atsushi Toyoda；Todd D. Taylor；Takehiko Itoh；Shih-Feng Tsai；Hong-
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Asao Fujiyama；Hidemi Watanabe；Atsushi Toyoda；Todd D. Taylor；Takehiko Itoh；Shih-Feng Tsai；Hong-Seog Park；Marie-Laure Yaspo；Hans Lehrach；Zhu Chen；Gang Fu；Naruya Saitou；Kazutoyo Osoegawa；Pieter J. de Jong；Yumiko Suto；Masahira Hattori；Yoshiyuki Sakaki1
关键词：Human；Chimpanzee； Clone Map
摘要：The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.
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