碱性成纤维细胞生长因子与肝素结合性质的研究进展
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华南理工大学生物工程系 广东广州510640 熊盛；林剑；姚汝华；宗敏华
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华南理工大学生物工程系 广东广州510640 熊盛；林剑；姚汝华；宗敏华
关键词：成纤维细胞生长因子；碱性；肝素
摘要：Basic fibroblast growth factor (bFGF) is a multi-potential growth factor whose biological activities depend on its receptor's intrinsic tyrosine kinase activity and second messengers such as the mitogen activated protein kinases. Heparin sulfate proteoglycans (HSPGs) have been demonstrated to enhance or inhibit bFGF activity. The response elicited by HSPG is related to the relative concentrations and binding kinetics for bFGF of the various pools of HSPG. The type of cellular response might depend on the...
华南理工大学生物工程系 广东广州510640 熊盛；林剑；姚汝华；宗敏华
关键词：成纤维细胞生长因子；碱性；肝素
摘要：Basic fibroblast growth factor (bFGF) is a multi-potential growth factor whose biological activities depend on its receptor's intrinsic tyrosine kinase activity and second messengers such as the mitogen activated protein kinases. Heparin sulfate proteoglycans (HSPGs) have been demonstrated to enhance or inhibit bFGF activity. The response elicited by HSPG is related to the relative concentrations and binding kinetics for bFGF of the various pools of HSPG. The type of cellular response might depend on the...
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