经皮冠状动脉腔内成形术后P物质对冠状动脉非病变血管的舒张作用(摘要)
作者：张月兰 赵卫华 金琳
单位：辽宁省沈阳市，中国医科大学第一临床学院 循环内科(110001) 张月兰 赵卫华；沈阳机车车辆厂医院 内二科 金 琳
关键词：
目的 目的：探讨经皮冠状动脉腔内成形术(PTCA)后不同时间冠状动脉非病变血管对不同剂量P物质的舒张作用。
方法：对13例男性冠心病(陈旧性心肌梗塞7例，不稳定性心绞痛6例，年龄59～67岁)患者于PTCA后第1天及3个月进行P物质(13.5 ng、40 ng、135 ng)负荷冠状动脉造影，同时与生理盐水和硝酸甘油的冠状动脉造影相对照，采用XR-70型Coronary Analyzer用密度测量法于舒张末期分别测量冠状动脉非病变Ⅰ级，Ⅱ、Ⅲ级血管的中间部位。13名患者测冠状动脉非病变Ⅰ级，Ⅱ、Ⅲ级血管分别为23、19支。
, 百拇医药
结果：PTCA后第1天冠状动脉非病变Ⅱ、Ⅲ级血管对不同剂量P物质的舒张反应差异性不显著。PTCA后3个月冠状动脉非病变Ⅱ、Ⅲ级血管对不同剂量P物质舒张反应的组间差异性显著。PTCA后3个月冠状动脉非病变Ⅰ级血管依赖性舒张反应较第1天明显，但差异性不显著。PTCA后3个月较第1天冠状动脉非病变Ⅱ、Ⅲ级，Ⅰ级血管对P物质135 ng组的舒张反应差异性显著，但对P物质13.5 ng和40 ng组反应不明显。PTCA后3个月较第1天冠状动脉非病变Ⅱ、Ⅲ级，Ⅰ级血管对硝酸甘油的反应差异性显著。
结论：PTCA后不同时间冠状动脉非病变Ⅰ级血管对P物质的内皮依赖性舒张作用均较强；PTCA后早期冠状动脉非病变Ⅱ、Ⅲ级血管内皮依赖性舒张能力低下，但术后3个月即得到明显恢复。
Endothelium-Dependent Vasodilation Effect of Substance P on Non-Affected
, 百拇医药
Vessels after Percutaneous Transluminal Coronary Angioplasty (Abstract)
Department of Cardiology, The First Affiliated Hospital, China Medical University, Shenyang (110001), Liaoning
Zhang Yuelan, Zhao Weihua, Jin Lin.
Objective: To evaluate the endothelium-dependent vasodilation effect on non-affected vessels by different doses of substance P (SP) after percutaneous transluminal coronary angioplasty (PTCA).
, http://www.100md.com
Methods: Thirteen patients with coronary heart disease were given coronary angiography (CAG) with SP load on the first day and 3 months after PTCA. SP 13.5 ng、 40 ng、 135 ng were injected into coronary artery separately and CAG was performed 2 minutes after each injection. In control group 2 ml nature saline or 200 μg nitroglycerin (NTG) was given instead of SP. Coronary artery lurminal diameters of non-affected grade 1 and grade 2～3 vessels were measured separately on the recorded film by density measurement.
, 百拇医药
Results: On the first day after PTCA, the SP had little dilating effect on grade 2～3 vessels in all groups. But different doses of SP dilated grade 2～3 vessels in a dose-dependent manner at 3 months after PTCA (p<0.05～0.01). All three doses of SP dilated the grade 1 vessels on the first day and at 3 months after PTCA (p<0.05～0.01).
Conclusion: At different time after PTCA, endothelum-dependent vasodilation on the non-affected grade 1 vessels was better than on the grade 2～3 vessels. In the early period after PTCA, endothelium-dependent vasodilation produced by SP was impaired in non-affected grade 2～3 vessels, but the endothelial dysfunction was ameliorated 3 months after PTCA., 百拇医药
单位：辽宁省沈阳市，中国医科大学第一临床学院 循环内科(110001) 张月兰 赵卫华；沈阳机车车辆厂医院 内二科 金 琳
关键词：
目的 目的：探讨经皮冠状动脉腔内成形术(PTCA)后不同时间冠状动脉非病变血管对不同剂量P物质的舒张作用。
方法：对13例男性冠心病(陈旧性心肌梗塞7例，不稳定性心绞痛6例，年龄59～67岁)患者于PTCA后第1天及3个月进行P物质(13.5 ng、40 ng、135 ng)负荷冠状动脉造影，同时与生理盐水和硝酸甘油的冠状动脉造影相对照，采用XR-70型Coronary Analyzer用密度测量法于舒张末期分别测量冠状动脉非病变Ⅰ级，Ⅱ、Ⅲ级血管的中间部位。13名患者测冠状动脉非病变Ⅰ级，Ⅱ、Ⅲ级血管分别为23、19支。
, 百拇医药
结果：PTCA后第1天冠状动脉非病变Ⅱ、Ⅲ级血管对不同剂量P物质的舒张反应差异性不显著。PTCA后3个月冠状动脉非病变Ⅱ、Ⅲ级血管对不同剂量P物质舒张反应的组间差异性显著。PTCA后3个月冠状动脉非病变Ⅰ级血管依赖性舒张反应较第1天明显，但差异性不显著。PTCA后3个月较第1天冠状动脉非病变Ⅱ、Ⅲ级，Ⅰ级血管对P物质135 ng组的舒张反应差异性显著，但对P物质13.5 ng和40 ng组反应不明显。PTCA后3个月较第1天冠状动脉非病变Ⅱ、Ⅲ级，Ⅰ级血管对硝酸甘油的反应差异性显著。
结论：PTCA后不同时间冠状动脉非病变Ⅰ级血管对P物质的内皮依赖性舒张作用均较强；PTCA后早期冠状动脉非病变Ⅱ、Ⅲ级血管内皮依赖性舒张能力低下，但术后3个月即得到明显恢复。
Endothelium-Dependent Vasodilation Effect of Substance P on Non-Affected
, 百拇医药
Vessels after Percutaneous Transluminal Coronary Angioplasty (Abstract)
Department of Cardiology, The First Affiliated Hospital, China Medical University, Shenyang (110001), Liaoning
Zhang Yuelan, Zhao Weihua, Jin Lin.
Objective: To evaluate the endothelium-dependent vasodilation effect on non-affected vessels by different doses of substance P (SP) after percutaneous transluminal coronary angioplasty (PTCA).
, http://www.100md.com
Methods: Thirteen patients with coronary heart disease were given coronary angiography (CAG) with SP load on the first day and 3 months after PTCA. SP 13.5 ng、 40 ng、 135 ng were injected into coronary artery separately and CAG was performed 2 minutes after each injection. In control group 2 ml nature saline or 200 μg nitroglycerin (NTG) was given instead of SP. Coronary artery lurminal diameters of non-affected grade 1 and grade 2～3 vessels were measured separately on the recorded film by density measurement.
, 百拇医药
Results: On the first day after PTCA, the SP had little dilating effect on grade 2～3 vessels in all groups. But different doses of SP dilated grade 2～3 vessels in a dose-dependent manner at 3 months after PTCA (p<0.05～0.01). All three doses of SP dilated the grade 1 vessels on the first day and at 3 months after PTCA (p<0.05～0.01).
Conclusion: At different time after PTCA, endothelum-dependent vasodilation on the non-affected grade 1 vessels was better than on the grade 2～3 vessels. In the early period after PTCA, endothelium-dependent vasodilation produced by SP was impaired in non-affected grade 2～3 vessels, but the endothelial dysfunction was ameliorated 3 months after PTCA., 百拇医药