灌注压对左心室壁心肌层间血流影响的建模与仿真研究
作者：王怀阳 郑振声 吴晓明 岑人经
单位：王怀阳(海信集团技术中心智能技术研究所 青岛 266071)；郑振声(中山医科大学卫生部辅助循环重点实验室 广州 510089)；吴晓明 岑人经(华南理工大学生物力学研究所 广州 510640)
关键词：血流动力学；冠脉循环；数学模型；体外反搏
医用生物力学000305摘 要：为了研究心肌各层间交换血流的时相分布，建立了一个左心室壁血流灌注计算机仿真模型。心室壁分为三层，每层中的血管网用一时变阻容网络来代表。以六条雄性犬的左心室压和主动脉压的实测数据作为输入进行仿真。结果表明，用体外反搏的方法提高灌注压对心肌各层间交换血洗有明显改善. A STUDY OF TIME-DEPENDENT BLOOD FLOWS AMONG MYOCARDIUM LAYERS AND THEIR DEPENDENCE ON PERFUSING PRESSURE WITH MODELING AND EMULATON
Wang Huaiyang
(Inteligence Technique Laboratory, Technique Center, Hisense Corporation, Qingdao 266071)
Zheng Zhensheng
(Assistant Circulation Institute, Sun Yat-sen University of Medical Sciences, Guangzhou 510089)
Wu Xiaoming
(Biomechanics Institute, South China University of Technology, Guangzhou 510640)
Abstract：A mathematical model was proposed for studying the time-dependent blood flows among myocardium layers. There were three classical myocardial vascular nets in each part and each net was represented by a branch of time-dependent nonlinear resistance and compliance. Experimentally measured aortic pressure and left ventricular pressure from six male dogs were taken as input data fbr emulation. The results show that the blood flows among myocardium predicted with the model were increased obviously with augmentation of the perfusing pressure by EECP.
Keywords：Hemodynamics, Circulation, Mathematical model, External counterpulsation.
参考文献：
[1]郑振声.体外反搏的历史回顾、现状与展望.现代医学仪器与应用.1992；4(2)：3～5.
[2]郑振声，詹澄扬.增强型体外反搏装置的设计和工作原理.中国生物医学工程学报.1984；3(3)：133～137.
[3]刘琼，郑振声，吴云鹏等.用模型方法研究心肌血流的时相分布及其灌注压依赖性.生物医学工程杂志.1997；14(3)：212.
[4]王怀阳.体外反搏对缺血心肌血流灌注和剪切应力影响的建模仿真与实验研究.中山医科大学生物医学工程专业博士论文.1999.7, 百拇医药
单位：王怀阳(海信集团技术中心智能技术研究所 青岛 266071)；郑振声(中山医科大学卫生部辅助循环重点实验室 广州 510089)；吴晓明 岑人经(华南理工大学生物力学研究所 广州 510640)
关键词：血流动力学；冠脉循环；数学模型；体外反搏
医用生物力学000305摘 要：为了研究心肌各层间交换血流的时相分布，建立了一个左心室壁血流灌注计算机仿真模型。心室壁分为三层，每层中的血管网用一时变阻容网络来代表。以六条雄性犬的左心室压和主动脉压的实测数据作为输入进行仿真。结果表明，用体外反搏的方法提高灌注压对心肌各层间交换血洗有明显改善. A STUDY OF TIME-DEPENDENT BLOOD FLOWS AMONG MYOCARDIUM LAYERS AND THEIR DEPENDENCE ON PERFUSING PRESSURE WITH MODELING AND EMULATON
Wang Huaiyang
(Inteligence Technique Laboratory, Technique Center, Hisense Corporation, Qingdao 266071)
Zheng Zhensheng
(Assistant Circulation Institute, Sun Yat-sen University of Medical Sciences, Guangzhou 510089)
Wu Xiaoming
(Biomechanics Institute, South China University of Technology, Guangzhou 510640)
Abstract：A mathematical model was proposed for studying the time-dependent blood flows among myocardium layers. There were three classical myocardial vascular nets in each part and each net was represented by a branch of time-dependent nonlinear resistance and compliance. Experimentally measured aortic pressure and left ventricular pressure from six male dogs were taken as input data fbr emulation. The results show that the blood flows among myocardium predicted with the model were increased obviously with augmentation of the perfusing pressure by EECP.
Keywords：Hemodynamics, Circulation, Mathematical model, External counterpulsation.
参考文献：
[1]郑振声.体外反搏的历史回顾、现状与展望.现代医学仪器与应用.1992；4(2)：3～5.
[2]郑振声，詹澄扬.增强型体外反搏装置的设计和工作原理.中国生物医学工程学报.1984；3(3)：133～137.
[3]刘琼，郑振声，吴云鹏等.用模型方法研究心肌血流的时相分布及其灌注压依赖性.生物医学工程杂志.1997；14(3)：212.
[4]王怀阳.体外反搏对缺血心肌血流灌注和剪切应力影响的建模仿真与实验研究.中山医科大学生物医学工程专业博士论文.1999.7, 百拇医药