TGF对牙齿发育的调节
作者：徐彬 柏树令
单位：中国医科大学解剖教研室 沈阳 110001
关键词：TGF调节，牙齿发育；反义寡核苷酸
解剖科学进展000312摘 要：在胚胎发育过程中，TGF-βⅡ受体是TGF-β调节牙齿形成通路的关键因素.TGF-β2或EGF表达不足时会严重影响牙齿的发育。TGF-βⅡ受体失活改变了内源性TGF-β信号系统对器官上皮细胞增生的负向调节效应，从而刺激了牙的胚胎发育。 Regulation of TGF on the Development of Tooth
Xu Bin ,Bai Shuling
(Department of Anatomy, China Medical University Shenyang 110001)
Abstract：TGF-β Ⅱ R is key point for TGF-β regulating the formation of tooth. Under expression of TGF-β2 or EGF severely affected tooth development. Our results demonstrated that abrogation of TGF-β Ⅱ R Stimulated embryonic tooth development through changing the negative regulation of endogeneous TGF-β signaling upon enamel epithelial cell proliferation.
Keywords：TGF regulation; tooth development; antisense ODN
参考文献：
[1]Iseki S, Osumi-yamashita N, Miyazono K, et al. Localization of transforming growth factor-beta type I and type Ⅱ receptors in mouse development. Exp Cell Res, 1995, 219: 339
[2]Kronmiller JE, Upholt WB, Kollar EJ. EGF antisense oligodeoxynucleotides block murine odontogenesis in vitro. Dev Biol, 1991, 147: 485
[3]Zhao J, Bu D, Lee M, et al. Abrogation of transforming growth factor-β type Ⅱ receptor stimulates embryonic mouse lung branching morphogenesis in culture. Dev Bio1, 1996, 180: 242
[4]Zhao J, Sime P J, Bringas PT, et al. Epithelium-specific adenoviral transfer of a dominant-negative mutant TGF-β type Ⅱ receptor stimulates embryonic lung branching morphogenesis in culture and potentiates EGF-β type Ⅱ receptor stimulates embryonic lung branching morphogenesis in culture and potentiates EGF and PDFG-AA. Mcch Dev, 1998, 72: 89, 百拇医药
单位：中国医科大学解剖教研室 沈阳 110001
关键词：TGF调节，牙齿发育；反义寡核苷酸
解剖科学进展000312摘 要：在胚胎发育过程中，TGF-βⅡ受体是TGF-β调节牙齿形成通路的关键因素.TGF-β2或EGF表达不足时会严重影响牙齿的发育。TGF-βⅡ受体失活改变了内源性TGF-β信号系统对器官上皮细胞增生的负向调节效应，从而刺激了牙的胚胎发育。 Regulation of TGF on the Development of Tooth
Xu Bin ,Bai Shuling
(Department of Anatomy, China Medical University Shenyang 110001)
Abstract：TGF-β Ⅱ R is key point for TGF-β regulating the formation of tooth. Under expression of TGF-β2 or EGF severely affected tooth development. Our results demonstrated that abrogation of TGF-β Ⅱ R Stimulated embryonic tooth development through changing the negative regulation of endogeneous TGF-β signaling upon enamel epithelial cell proliferation.
Keywords：TGF regulation; tooth development; antisense ODN
参考文献：
[1]Iseki S, Osumi-yamashita N, Miyazono K, et al. Localization of transforming growth factor-beta type I and type Ⅱ receptors in mouse development. Exp Cell Res, 1995, 219: 339
[2]Kronmiller JE, Upholt WB, Kollar EJ. EGF antisense oligodeoxynucleotides block murine odontogenesis in vitro. Dev Biol, 1991, 147: 485
[3]Zhao J, Bu D, Lee M, et al. Abrogation of transforming growth factor-β type Ⅱ receptor stimulates embryonic mouse lung branching morphogenesis in culture. Dev Bio1, 1996, 180: 242
[4]Zhao J, Sime P J, Bringas PT, et al. Epithelium-specific adenoviral transfer of a dominant-negative mutant TGF-β type Ⅱ receptor stimulates embryonic lung branching morphogenesis in culture and potentiates EGF-β type Ⅱ receptor stimulates embryonic lung branching morphogenesis in culture and potentiates EGF and PDFG-AA. Mcch Dev, 1998, 72: 89, 百拇医药