通腑逐瘀汤治疗新生儿胃肠功能衰竭的临床观察
作者：苏振军 彭桂兰 安文 岳伟 张平
单位：
关键词：婴儿，新生；胃肠功能衰竭；通腑逐瘀汤；中西医结合疗法
中国中西医结合急救杂志000118摘 要：目的：观察通腑逐瘀汤配合西医治疗新生儿胃肠功能衰竭的疗效。方法：108例患儿随机分为治疗组(54例)和对照组(54例)。2组均采用西医治疗(控制原发病，保护胃肠粘膜屏障，防治消化道出血及营养支持等)；治疗组加用自拟中药通腑逐瘀汤，每日1剂，治疗8日。结果：治疗组各项观察指标恢复快，并能有效阻止病情发展，治愈率明显高于对照组(2组分别为66.7%及27.8%，χ2=16.384，P<0.001)，病死率明显低于对照组(分别为31.5%及64.8%，χ2=12.016，P<0.001)。结论：通腑逐瘀汤配合西医治疗新生儿胃肠功能衰竭能有效促进胃肠道粘膜屏障功能的恢复，防止胃肠道有害菌易位及毒素吸收，阻断向多器官功能衰竭的发展，有利于胃肠功能恢复。
, 百拇医药
分类号：R723.1 文献标识码：A
文章编号：1008-9691(2000)01-0054-03
Clinical observation on treatment with Tongfu Zhuyu Decoction for gastrointestinal functional failure in infants
SU Zhen-jun,PENG Gui-lan,AN Wen,et al
(Zhumadian People′s Hospital,Henan Zhumadian 463000
Abstract：Objective：To observe the curative effects of Tongfu Zhuyu Decoction combined with western medicine (WM) on gastrointestinal functional failure(GFF) in infants.Methods：108 ill infants were randomly divided into treated group (n=54) and control group (n=54).Both groups were treated with WM,including controlling the primary diseases,protecting the barrier of gastrointestinal mucosa,preventing and treating the hemorrhage of digestive tract,and nutritional supports.In treated group the Tongfu Zhuyu Decoction prepared by authors once a day was added for eight days.Results：The remissions of every observational parameters were rapid,the progressions of pathogenetic conditions were effectively inhibited,and the cured rates in treated group were significantly higher than those in control group (66.7% vs.27.8%,χ2=16.384，P<0.001),but the mortality rate was significantly lower (31.5% vs.64.8%,χ2=12.016,P<0.001).Conclusions：The treatment with Tongfu Zhuyu Decoction combined with WM for GFF in infants is able to promote the remisson of barrier function of gastrointestinal tract effectively,to prevent the translocation of harmful bacteria and the absorption of toxins in gastrointestinal tract,impede the progression toward multiple organ failure,and benefit the convalescence of gastrointestinal functions.
, 百拇医药
Key words：infants;gastrointestinal functional failure;Tongfu Zhuyu Decoction;integrated traditional Chinese and western medicine therapy▲
新生儿胃肠功能衰竭的发病率相对不高，但由于其早期症状不典型，一旦确诊病情危重且多合并其它器官功能衰竭，而多系统器官功能衰竭(MSOF)是导致新生儿死亡的最终原因[1，2]。1997年开始，我们采用中西医结合方法治疗新生胃肠功能衰竭，报告如下。
1 资料与方法
1.1 病例选择与分组 ：108例符合诊断标准[3]的新生儿作为观察对象，并排除先天性消化道畸形及外科疾病。随机分为治疗组和对照组，每组各54例。2组患儿一般情况，原发病及治疗前合并器官衰竭数见表1。2组临床资料有可比性。
, 百拇医药
表1 2组患儿一般情况、原发病及治疗前器官衰竭数比较 组别
性别(例)
胎龄
(
，周)
日龄
(,d)
原发病(例)
器官衰竭数(例)
, 百拇医药
男
女
窒息
早产
坏死性小肠结肠炎
硬肿症
败血症
其它
0个
1个
2个
3个
4个
, 百拇医药 对照组
35
19
38.0±2.2
9.0±2.8
21
20
26
23
19
12
18
20
, 百拇医药 9
4
3
治疗组
36
18
38.0±2.6
8.0±3.4
20
22
24
25
18
10
, 百拇医药
17
22
8
5
2
表2 2组患儿各临床指标恢复正常时间比较() d 组别
例数(例)
呕吐消失
呕血消失
有肠鸣音
, 百拇医药
开始排便
腹胀消失
开奶时间
住院时间
潜血消失
腹透正常
对照组
54
5.0±1.8(22)
4.0±2.7(24)
6.0±2.5(16)
7.0±2.3(17)
, http://www.100md.com
10.0±3.5(16)
8.0±2.0(15)
18.0±6.5
7.0±2.0(18)
8.0±2.7(19)
治疗组
54
2.0±1.9(42)△
2.0±1.8(46)△
2.0±1.1(40)△
2.0±1.4(39)△
6.0±2.7(38)△
5.0±1.6(36)△
12.0±5.4△
3.0±2.2(42)Transfer interrupted!, 百拇医药
单位：
关键词：婴儿，新生；胃肠功能衰竭；通腑逐瘀汤；中西医结合疗法
中国中西医结合急救杂志000118摘 要：目的：观察通腑逐瘀汤配合西医治疗新生儿胃肠功能衰竭的疗效。方法：108例患儿随机分为治疗组(54例)和对照组(54例)。2组均采用西医治疗(控制原发病，保护胃肠粘膜屏障，防治消化道出血及营养支持等)；治疗组加用自拟中药通腑逐瘀汤，每日1剂，治疗8日。结果：治疗组各项观察指标恢复快，并能有效阻止病情发展，治愈率明显高于对照组(2组分别为66.7%及27.8%，χ2=16.384，P<0.001)，病死率明显低于对照组(分别为31.5%及64.8%，χ2=12.016，P<0.001)。结论：通腑逐瘀汤配合西医治疗新生儿胃肠功能衰竭能有效促进胃肠道粘膜屏障功能的恢复，防止胃肠道有害菌易位及毒素吸收，阻断向多器官功能衰竭的发展，有利于胃肠功能恢复。
, 百拇医药
分类号：R723.1 文献标识码：A
文章编号：1008-9691(2000)01-0054-03
Clinical observation on treatment with Tongfu Zhuyu Decoction for gastrointestinal functional failure in infants
SU Zhen-jun,PENG Gui-lan,AN Wen,et al
(Zhumadian People′s Hospital,Henan Zhumadian 463000
Abstract：Objective：To observe the curative effects of Tongfu Zhuyu Decoction combined with western medicine (WM) on gastrointestinal functional failure(GFF) in infants.Methods：108 ill infants were randomly divided into treated group (n=54) and control group (n=54).Both groups were treated with WM,including controlling the primary diseases,protecting the barrier of gastrointestinal mucosa,preventing and treating the hemorrhage of digestive tract,and nutritional supports.In treated group the Tongfu Zhuyu Decoction prepared by authors once a day was added for eight days.Results：The remissions of every observational parameters were rapid,the progressions of pathogenetic conditions were effectively inhibited,and the cured rates in treated group were significantly higher than those in control group (66.7% vs.27.8%,χ2=16.384，P<0.001),but the mortality rate was significantly lower (31.5% vs.64.8%,χ2=12.016,P<0.001).Conclusions：The treatment with Tongfu Zhuyu Decoction combined with WM for GFF in infants is able to promote the remisson of barrier function of gastrointestinal tract effectively,to prevent the translocation of harmful bacteria and the absorption of toxins in gastrointestinal tract,impede the progression toward multiple organ failure,and benefit the convalescence of gastrointestinal functions.
, 百拇医药
Key words：infants;gastrointestinal functional failure;Tongfu Zhuyu Decoction;integrated traditional Chinese and western medicine therapy▲
新生儿胃肠功能衰竭的发病率相对不高，但由于其早期症状不典型，一旦确诊病情危重且多合并其它器官功能衰竭，而多系统器官功能衰竭(MSOF)是导致新生儿死亡的最终原因[1，2]。1997年开始，我们采用中西医结合方法治疗新生胃肠功能衰竭，报告如下。
1 资料与方法
1.1 病例选择与分组 ：108例符合诊断标准[3]的新生儿作为观察对象，并排除先天性消化道畸形及外科疾病。随机分为治疗组和对照组，每组各54例。2组患儿一般情况，原发病及治疗前合并器官衰竭数见表1。2组临床资料有可比性。
, 百拇医药
表1 2组患儿一般情况、原发病及治疗前器官衰竭数比较 组别
性别(例)
胎龄
(
，周)日龄
(
,d)原发病(例)
器官衰竭数(例)
, 百拇医药
男
女
窒息
早产
坏死性小肠结肠炎
硬肿症
败血症
其它
0个
1个
2个
3个
4个
, 百拇医药 对照组
35
19
38.0±2.2
9.0±2.8
21
20
26
23
19
12
18
20
, 百拇医药 9
4
3
治疗组
36
18
38.0±2.6
8.0±3.4
20
22
24
25
18
10
, 百拇医药
17
22
8
5
2
表2 2组患儿各临床指标恢复正常时间比较(
) d 组别例数(例)
呕吐消失
呕血消失
有肠鸣音
, 百拇医药
开始排便
腹胀消失
开奶时间
住院时间
潜血消失
腹透正常
对照组
54
5.0±1.8(22)
4.0±2.7(24)
6.0±2.5(16)
7.0±2.3(17)
, http://www.100md.com
10.0±3.5(16)
8.0±2.0(15)
18.0±6.5
7.0±2.0(18)
8.0±2.7(19)
治疗组
54
2.0±1.9(42)△
2.0±1.8(46)△
2.0±1.1(40)△
2.0±1.4(39)△
6.0±2.7(38)△
5.0±1.6(36)△
12.0±5.4△
3.0±2.2(42)Transfer interrupted!, 百拇医药