视黄醇结合蛋白的临床应用
作者：陈小莉 蔡东联
单位：200433 上海，第二军医大学长海医院营养科(陈小莉)；解放军临床营养中心(蔡东联)
关键词：视黄醇结合蛋白；临床应用
中国临床营养杂志000104摘 要：对视黄醇结合蛋白(RBP)的临床应用进行了综述。RBP为血液中转运视黄醇的蛋白，半衰期短，体内含量较少，能较为灵敏地反映机体营养状况。RBP含量改变也能早期反映各种肾脏疾患及肝功能损害程度。
参考文献：
[1]Torres Y, Torres N. Advances in vitamin A and retinaid-binding proreins. Rev Invest Clin, 1995, 47: 149.
, 百拇医药
[2]Lindblad BS, Patel M, Hamadeh M, et al. Age and sex ere important factors in determing normal retinal levels. J Trop Pediatr, 1998, 44: 96.
[3]Sundaram M, Sivaprasadarao A, Desousa M, et al. The transfer of retinol from serum retinal hinding protein to cellular retinol binding protein is mediated by a membrane receptor. J Biol Chem, 1998, 273 :3336.
[4]Hodam J, Cree K. Comparison of the metabolism of retinol delibered to human keratinocytes either bound to serum retinol-binding protein or added directly to the culture medium. Exp Cell Res, 1998, 238: 257.
, http://www.100md.com
[5]Benabdeslam H, Garcia I, Brllon G, et al. Biochemical assessmant of the nutritional status of cystic fibrosis patients treated with pancreatic enzyme extracts. Am J Clin Nutr, 1998, 67: 912.
[6]Ihera H, Shino Y, Hashizume N, et al. Decline in plasma retinol in unconjugated hyperbilirubinemia treated with bilirubin adsorption usng an anion exchange resin. J Nutr Sci Vit, 1998, 44: 329.
[7]Lespine A, Periquet B, Jaconi S, et al. Decreases in retinal and retinal-binding protein during total perentersl nutrition in rats are not due to a vitamin A deficiency. J Lipid Res, 1996, 37: 2492.
, http://www.100md.com
[8]Ellis D, Forrest KY, Erbey F, et al. Urinary measurement of transforming growth factor-beta and type Ⅳ collagen es new markers of renal injury: application in diabetic nephropathy. Clin Chem, 1998, 44: 950.
[9]Stefano J, Keith G, Graham J, et al. Cheraterization of two post translationslly processed forms of human serum retinal binding protein: altered ratios in chronic rend failure. J Lipid Res, 1995, 36: 1247.
[10]Aguiera A, Codoceo R, Selgas R, et al. Anorexigen (TNF-alpha, cholecystokinin) and orexigen (neuropeptide Y) plasma levels in peritoneal dialysis (PD) patients: their relationship with nutritional parameters. Nephrol Dial Transplant, 1998, 13: 1476.
, 百拇医药
[11]Pai P, Stevenson A, Mason H, et al. Occupational hydrocarbon exposure and nephrotoxicity: cohort study and literature review. Postgrad Med J, 1998, 74: 225.
[12]Mestroianni A, Regalia E, Fswhrtti G, et al. Increased retinol binding protein in the of patients with severe isehemic damage of the liver after transplantation. Clin Biochem, 1998, 31: 113.
[13]Barga M, Vignali A, Gianotti A, et al. Immune and nutritional effects of early enteral nutrition after major abdominal operations. Eur J Surg, 1996, 162: 105.
, http://www.100md.com
[14]Valasques G, Roncada MJ, Topovski J, et al. Relationship between acute diarrhoea and low plasma levels of vitamin A and relation binding protein. Rev Inst Med Trop Sao Panlo, 1996, 38: 365.
[15]Git CI, Gimemo UC, Cos Al, et al. The nutritional status and respiratory function of patients diagnosed with COPD. Nutr Husp, 1995, 10: 87.
[16]Casari A, Muttini S, Leggieri C, et al. Rapid turnover proteins in critically ill ICU patients. Minerva Anestesiol, 1998, 64: 345.
收稿日期：1999-09-21
修稿日期：1999-10-26, 百拇医药
单位：200433 上海，第二军医大学长海医院营养科(陈小莉)；解放军临床营养中心(蔡东联)
关键词：视黄醇结合蛋白；临床应用
中国临床营养杂志000104摘 要：对视黄醇结合蛋白(RBP)的临床应用进行了综述。RBP为血液中转运视黄醇的蛋白，半衰期短，体内含量较少，能较为灵敏地反映机体营养状况。RBP含量改变也能早期反映各种肾脏疾患及肝功能损害程度。
参考文献：
[1]Torres Y, Torres N. Advances in vitamin A and retinaid-binding proreins. Rev Invest Clin, 1995, 47: 149.
, 百拇医药
[2]Lindblad BS, Patel M, Hamadeh M, et al. Age and sex ere important factors in determing normal retinal levels. J Trop Pediatr, 1998, 44: 96.
[3]Sundaram M, Sivaprasadarao A, Desousa M, et al. The transfer of retinol from serum retinal hinding protein to cellular retinol binding protein is mediated by a membrane receptor. J Biol Chem, 1998, 273 :3336.
[4]Hodam J, Cree K. Comparison of the metabolism of retinol delibered to human keratinocytes either bound to serum retinol-binding protein or added directly to the culture medium. Exp Cell Res, 1998, 238: 257.
, http://www.100md.com
[5]Benabdeslam H, Garcia I, Brllon G, et al. Biochemical assessmant of the nutritional status of cystic fibrosis patients treated with pancreatic enzyme extracts. Am J Clin Nutr, 1998, 67: 912.
[6]Ihera H, Shino Y, Hashizume N, et al. Decline in plasma retinol in unconjugated hyperbilirubinemia treated with bilirubin adsorption usng an anion exchange resin. J Nutr Sci Vit, 1998, 44: 329.
[7]Lespine A, Periquet B, Jaconi S, et al. Decreases in retinal and retinal-binding protein during total perentersl nutrition in rats are not due to a vitamin A deficiency. J Lipid Res, 1996, 37: 2492.
, http://www.100md.com
[8]Ellis D, Forrest KY, Erbey F, et al. Urinary measurement of transforming growth factor-beta and type Ⅳ collagen es new markers of renal injury: application in diabetic nephropathy. Clin Chem, 1998, 44: 950.
[9]Stefano J, Keith G, Graham J, et al. Cheraterization of two post translationslly processed forms of human serum retinal binding protein: altered ratios in chronic rend failure. J Lipid Res, 1995, 36: 1247.
[10]Aguiera A, Codoceo R, Selgas R, et al. Anorexigen (TNF-alpha, cholecystokinin) and orexigen (neuropeptide Y) plasma levels in peritoneal dialysis (PD) patients: their relationship with nutritional parameters. Nephrol Dial Transplant, 1998, 13: 1476.
, 百拇医药
[11]Pai P, Stevenson A, Mason H, et al. Occupational hydrocarbon exposure and nephrotoxicity: cohort study and literature review. Postgrad Med J, 1998, 74: 225.
[12]Mestroianni A, Regalia E, Fswhrtti G, et al. Increased retinol binding protein in the of patients with severe isehemic damage of the liver after transplantation. Clin Biochem, 1998, 31: 113.
[13]Barga M, Vignali A, Gianotti A, et al. Immune and nutritional effects of early enteral nutrition after major abdominal operations. Eur J Surg, 1996, 162: 105.
, http://www.100md.com
[14]Valasques G, Roncada MJ, Topovski J, et al. Relationship between acute diarrhoea and low plasma levels of vitamin A and relation binding protein. Rev Inst Med Trop Sao Panlo, 1996, 38: 365.
[15]Git CI, Gimemo UC, Cos Al, et al. The nutritional status and respiratory function of patients diagnosed with COPD. Nutr Husp, 1995, 10: 87.
[16]Casari A, Muttini S, Leggieri C, et al. Rapid turnover proteins in critically ill ICU patients. Minerva Anestesiol, 1998, 64: 345.
收稿日期：1999-09-21
修稿日期：1999-10-26, 百拇医药