干细胞因子信号传导的研究进展
http://www.100md.com
37c医学网
作者：张浩 李晓霞 毛秉智
单位：张浩 毛秉智(军事医学科学院放射医学研究所，北京 100850)；李晓霞(解放军总医院临床检验科，北京 100853)
关键词：干细胞因子；信号传导
免疫学杂志010120 摘 要：干细胞因子(stem cell factor，SCF)通过与其受体c-kit结合发挥生物学作用。本文综述了JAK/STAT家族的JAK2、STAT1、STAT3、STAT5，Src家族的Lyn、Fyn、Lck在SCF信号传导的2条重要途径中的作用。
分类号：R392 文献标识码：A
文章编号：1000-8861(2001)01-0066-03
Advance in signal transduction of stem cell factor
, http://www.100md.com
ZHANG Hao(Institute of Radiation Medicine，Academic Military Medical Science， Beijing 100850，China)
LI Xiao-xia(General Hospital of PLA，Beijing 100853，China)
Abstract：Stem cell factor fulfills its biological function through c-kit，which belongs to receptor tyrosine kinase.The article summarizes the function of members of JAK/STAT (JAK2、STAT1、STAT3、STAT5) and members of Src(Lyn、Fyn、Lck) in signal transduction of stem cell factor.
, 百拇医药
Keywords：stem cell factor；signal transduction
作者简介：张浩(1968-)，男，天津市人，助研，博士，主要从事急性放射病基因治疗研究。 Tel：(010)66931214；E-mail：zhanghao@nic.bmi.ac.cn
参考文献：
[1]Weiler SR， Mou S， Deberry CS. JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor [J].Blood， 1996， 87(9)： 3 688-3 693.
[2]Linnekin D， Weiler SR， Mou S. JAK2 is constitutively associated with c-Kit and is phosphorylated in response to stem cell factor [J]. Acta Haematol，1996， 95(3，4)：224-228.
, 百拇医药
[3]Neubauer H， Cumano A， Wu H. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis [J]. Cell，1998， 93(3)：397-409.
[4]Parganas E， Wang D， Stravopodis D，et al. Topham DJ Jak2 is essential for signaling through a variety of cytokine receptors [J]. Cell， 1998， 93(3)： 385-395.
[5]Kozlowski M， Larose L， Lee F. SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain [J]. Mol Cell Biol， 1998， 18(4)： 2 089-2 099.
, 百拇医药
[6]Deberry C， Mou S， Linnekin D. Stat1 associates with c-kit and is activated in response to stem cell factor [J]. Biochem J， 1997， 327 (1)： 73-80.
[7]Brizzi MF， Dentelli P， Rosso A.STAT protein recruitment and activation in c-Kit deletion mutants [J]. J Biol Chem， 1999， 274(24)： 16 965-16 972.
[8]Gotoh M. Steel factor induces serine phosphorylation of Stat3 in human growth factor dependent myeloid cell lines [J]. Blood， 1996， 88(1)： 138-145.
, http://www.100md.com
[9]Jacobs-Helber SM， Penta K， Sun Z. Distinct signaling from stem cell factor and erythropoietin in HCD57 cells [J]. J Biol Chem， 1997， 272(11)： 6 850-6 853.
[10]Linnekin D， Deberry CS， Mou S. Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells [J]. J Biol Chem， 1997， 272(43)： 27 450-27 455.
[11]Krystal GW， Deberry CS， Linnekin D. Lck associates with and is activated by Kit in a small cell lung cancer cell line： inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1 [J]. Cancer Res， 1998， 58(20)： 4 660-4 666.
, http://www.100md.com
[12]Broudy VC， Lin NL， Liles WC. Signaling via Src family kinases is required for normal internalization of the receptor c-Kit [J]. Blood， 1999， 94(6)： 1 979-1 986.
[13]Price DJ， Rivnay B， Fu Y. Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes [J]. J Biol Chem， 1997， 272(9)： 5 915-5 920.
[14]Grgurevich S， Linnekin D， Musso T. The Csk-like proteins Lsk， Hyl， and Matk represent the same Csk homologous kinase (Chk) and are regulated by stem cell factor in the megakaryoblastic cell line MO7e [J]. Growth Factors， 1997， 14(2，3)： 103-105.
收稿日期：2000年6月15日
修稿日期：2000年9月19日
出版日期：2001年1月15日, 百拇医药
单位：张浩 毛秉智(军事医学科学院放射医学研究所，北京 100850)；李晓霞(解放军总医院临床检验科，北京 100853)
关键词：干细胞因子；信号传导
免疫学杂志010120 摘 要：干细胞因子(stem cell factor，SCF)通过与其受体c-kit结合发挥生物学作用。本文综述了JAK/STAT家族的JAK2、STAT1、STAT3、STAT5，Src家族的Lyn、Fyn、Lck在SCF信号传导的2条重要途径中的作用。
分类号：R392 文献标识码：A
文章编号：1000-8861(2001)01-0066-03
Advance in signal transduction of stem cell factor
, http://www.100md.com
ZHANG Hao(Institute of Radiation Medicine，Academic Military Medical Science， Beijing 100850，China)
LI Xiao-xia(General Hospital of PLA，Beijing 100853，China)
Abstract：Stem cell factor fulfills its biological function through c-kit，which belongs to receptor tyrosine kinase.The article summarizes the function of members of JAK/STAT (JAK2、STAT1、STAT3、STAT5) and members of Src(Lyn、Fyn、Lck) in signal transduction of stem cell factor.
, 百拇医药
Keywords：stem cell factor；signal transduction
作者简介：张浩(1968-)，男，天津市人，助研，博士，主要从事急性放射病基因治疗研究。 Tel：(010)66931214；E-mail：zhanghao@nic.bmi.ac.cn
参考文献：
[1]Weiler SR， Mou S， Deberry CS. JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor [J].Blood， 1996， 87(9)： 3 688-3 693.
[2]Linnekin D， Weiler SR， Mou S. JAK2 is constitutively associated with c-Kit and is phosphorylated in response to stem cell factor [J]. Acta Haematol，1996， 95(3，4)：224-228.
, 百拇医药
[3]Neubauer H， Cumano A， Wu H. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis [J]. Cell，1998， 93(3)：397-409.
[4]Parganas E， Wang D， Stravopodis D，et al. Topham DJ Jak2 is essential for signaling through a variety of cytokine receptors [J]. Cell， 1998， 93(3)： 385-395.
[5]Kozlowski M， Larose L， Lee F. SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain [J]. Mol Cell Biol， 1998， 18(4)： 2 089-2 099.
, 百拇医药
[6]Deberry C， Mou S， Linnekin D. Stat1 associates with c-kit and is activated in response to stem cell factor [J]. Biochem J， 1997， 327 (1)： 73-80.
[7]Brizzi MF， Dentelli P， Rosso A.STAT protein recruitment and activation in c-Kit deletion mutants [J]. J Biol Chem， 1999， 274(24)： 16 965-16 972.
[8]Gotoh M. Steel factor induces serine phosphorylation of Stat3 in human growth factor dependent myeloid cell lines [J]. Blood， 1996， 88(1)： 138-145.
, http://www.100md.com
[9]Jacobs-Helber SM， Penta K， Sun Z. Distinct signaling from stem cell factor and erythropoietin in HCD57 cells [J]. J Biol Chem， 1997， 272(11)： 6 850-6 853.
[10]Linnekin D， Deberry CS， Mou S. Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells [J]. J Biol Chem， 1997， 272(43)： 27 450-27 455.
[11]Krystal GW， Deberry CS， Linnekin D. Lck associates with and is activated by Kit in a small cell lung cancer cell line： inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1 [J]. Cancer Res， 1998， 58(20)： 4 660-4 666.
, http://www.100md.com
[12]Broudy VC， Lin NL， Liles WC. Signaling via Src family kinases is required for normal internalization of the receptor c-Kit [J]. Blood， 1999， 94(6)： 1 979-1 986.
[13]Price DJ， Rivnay B， Fu Y. Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes [J]. J Biol Chem， 1997， 272(9)： 5 915-5 920.
[14]Grgurevich S， Linnekin D， Musso T. The Csk-like proteins Lsk， Hyl， and Matk represent the same Csk homologous kinase (Chk) and are regulated by stem cell factor in the megakaryoblastic cell line MO7e [J]. Growth Factors， 1997， 14(2，3)： 103-105.
收稿日期：2000年6月15日
修稿日期：2000年9月19日
出版日期：2001年1月15日, 百拇医药