【摘要】 肠上皮细胞及其之间的紧密连接是肠黏膜屏障的重要组成部分。炎症性肠病中可出现肠上皮屏障的损伤，会导致肠黏膜的反复受损和修复。上皮损伤的修复取决于附近上皮细胞的迁移、增殖和分化。多种生长因子、细胞因子、三叶因子参与了调节肠道上皮损伤的修复，近年来还发现固有免疫中的Toll样受体和NOD样受体对维持肠内稳态和肠黏膜修复也起着重要作用。

    【关键词】 炎症性肠病;上皮细胞;细胞修复;胞间信号肽类和蛋白质类;固有免疫

    【Abstract】 Intestinal epithelial cells and tight intercellular junction are important components of intestinal mucosal barrier. The epithelial barrier damage may occur in inflammatory bowel disease， which leads to recurrent injury and repair of the intestinal mucosa. The process of epithelial injury repair relies upon the migration ......