【摘要】 目的 分析碳青霉烯类耐药的大肠埃希菌(E.Coli)耐药基因型与所含的毒力因子的关系。方法 PCR检测E.Coli毒力因子和耐药基因;采用Fisher确切概率法对耐药基因和毒力因子的关系进行分析。结果 95.7%(22/23)菌株超广谱β-内酰胺酶(ESBL)基因阳性，43.5%(10/23)菌株检出胞外黏多糖相关基因，87.0%(20/23)菌株检出P菌毛相关基因。耐药基因CTX-M-15型比CTX-M-55型菌株携带毒力因子papGⅡ的概率低(P = 0.049)。耐药基因NDM-1阳性菌株比NDM-5阳性菌株中毒力因子papGⅢ携带率高(P = 0.047)。 结论 ESBL阳性菌株中不同CTX-M、NDM亚型与毒力因子papGⅡ、papGⅢ具有一定的相关性，毒力因子的携带情况与E.Coli耐药情况可能有关。

    【关键词】 大肠埃希菌;毒力因子;耐药基因;超广谱β-内酰胺酶;碳青霉烯类耐药的肠杆菌科细菌

    【Abstract】 Objective To investigate the correlation between the genotype of drug-resistant genes and the virulence factors in carbapenem-resistant Escherichia coli(E.Coli) strains. Methods The virulence factors and drug-resistant genes were detected by PCR. The relationship between drug resistance genes and virulence factors was analyzed by Fisher’s exact test. Results A total of 95.7% (22/23) of the bacterial strains were positive for extended spectrum beta-lactamase (ESBLs) gene ......