慢性肾脏病患者血清尿酸水平与全因死亡率的关系分析(1)
【摘要】 目的 分析慢性肾脏病(CKD)患者的血清尿酸水平，探讨血清尿酸与CKD患者全因死亡率的关系。方法 选择1016例CKD住院患者，記录其人口学特征、合并症、BMI和实验室检查数据，根据血清尿酸水平四分位数将患者分为Q1 ～ Q4组，比较不同尿酸水平CKD患者的临床特征。同时收集患者全因死亡事件及死亡时间，利用Cox比例风险回归模型评估血清尿酸水平与全因死亡率之间的关系。结果 1016例CKD患者的血清尿酸为(404±138)μmol/L。对1016例患者随访(42.9±19.7)月，死亡91例。根据血清尿酸水平四分位数将患者分为Q1组(488 ～ 710 μmol/L)、 Q2组(393 ～ 487 μmol/L)、Q3组(306 ～ 392 μmol/L)、 Q4组(91 ～ 305 μmol/L)，每组各254例。4组中，Q1组白蛋白、HDL-C、血红蛋白、估算肾小球滤过率及CKD1期者比例较低，其血钾、血磷、血清尿酸、血清前白蛋白较高，与其他3组比较差异均有统计学意义(P < 0.05或0.008)。Cox比例风险回归模型分析中模型6的C指数最高，其结果示CKD患者的血清尿酸水平与全因死亡率无关(P > 0.05)。结论 CKD患者血清尿酸水平与全因死亡率可能无关。
【关键词】 尿酸;慢性肾脏病;全因死亡率
Analysis of relationship between serum uric acid level and all-cause mortality in patients with chronic kidney disease Zhang Yunqiang， Li Minjia， Liu Hongyong， Liu Zifeng， Li Shengrong， Liao Zhibo， Liu Xun. Department of Nephropathy， the Third Affiliated Hospital of Sun Yat-sen University， Yuedong Hospital， Meizhou 514700， China
Corresponding author， Liu Xun， E-mail： naturestyle@ 163. com
【Abstract】 Objective To measure the serum uric acid level and investigate the relationship between the serum uric acid level and all-cause mortality in patients with chronic kidney disease (CKD). Methods A total of 1016 CKD patients admitted to our hospital were recruited in this study. Demographic characteristics， complications， body mass index (BMI) and laboratory test data were recorded. All patients were divided into Q1-Q4 groups according to the quartile of serum uric acid level. Clinical characteristics were statistically compared among four groups. All-cause mortality events and time were collected. The relationship between the serum uric acid level and all-cause mortality was analyzed by using the Cox proportional hazards regression model. Results The serum uric acid level of 1016 CKD patients was measured as (404±138) μmol/L. The mean follow-up time was (42.9±19.7) months and 91 cases died during follow-up. According to the quartile of serum uric acid level， all patients were assigned into the Q1 (488-710 μmol/L)， Q2 (393-487 μmol/L)， Q3 (306-392 μmol/L) and Q4 (91-305 μmol/L) groups. In the Q1 group， the HDL-C， hemoglobin， eGFR and the proportion of patients with stage I CKD were significantly lower， whereas the blood potassium， blood phosphorus， serum uric acid and serum prealbumin levels were remarkably higher compared with those in the other three groups (all P < 0.05 or 0.008). Cox proportional hazard regression models demonstrated that the C-index in model 6 was the highest. The serum uric acid level was not significantly correlated with the all-cause mortality in CKD patients (P > 0.05). Conclusion The serum uric acid level is probably not associated with the all-cause mortality in patients with CKD., 百拇医药(张运强?李敏佳?刘红勇?刘子锋?李胜荣?廖志波?刘迅)
【关键词】 尿酸;慢性肾脏病;全因死亡率
Analysis of relationship between serum uric acid level and all-cause mortality in patients with chronic kidney disease Zhang Yunqiang， Li Minjia， Liu Hongyong， Liu Zifeng， Li Shengrong， Liao Zhibo， Liu Xun. Department of Nephropathy， the Third Affiliated Hospital of Sun Yat-sen University， Yuedong Hospital， Meizhou 514700， China
Corresponding author， Liu Xun， E-mail： naturestyle@ 163. com
【Abstract】 Objective To measure the serum uric acid level and investigate the relationship between the serum uric acid level and all-cause mortality in patients with chronic kidney disease (CKD). Methods A total of 1016 CKD patients admitted to our hospital were recruited in this study. Demographic characteristics， complications， body mass index (BMI) and laboratory test data were recorded. All patients were divided into Q1-Q4 groups according to the quartile of serum uric acid level. Clinical characteristics were statistically compared among four groups. All-cause mortality events and time were collected. The relationship between the serum uric acid level and all-cause mortality was analyzed by using the Cox proportional hazards regression model. Results The serum uric acid level of 1016 CKD patients was measured as (404±138) μmol/L. The mean follow-up time was (42.9±19.7) months and 91 cases died during follow-up. According to the quartile of serum uric acid level， all patients were assigned into the Q1 (488-710 μmol/L)， Q2 (393-487 μmol/L)， Q3 (306-392 μmol/L) and Q4 (91-305 μmol/L) groups. In the Q1 group， the HDL-C， hemoglobin， eGFR and the proportion of patients with stage I CKD were significantly lower， whereas the blood potassium， blood phosphorus， serum uric acid and serum prealbumin levels were remarkably higher compared with those in the other three groups (all P < 0.05 or 0.008). Cox proportional hazard regression models demonstrated that the C-index in model 6 was the highest. The serum uric acid level was not significantly correlated with the all-cause mortality in CKD patients (P > 0.05). Conclusion The serum uric acid level is probably not associated with the all-cause mortality in patients with CKD., 百拇医药(张运强?李敏佳?刘红勇?刘子锋?李胜荣?廖志波?刘迅)
参见：首页 > 医疗版 > 疾病专题 > 泌尿外科 > 肾脏 > 肾脏知识