颉雅苹?童志杰?樊慧峰?卢秉泰?陈容珊

    【摘要】目的 研究CD4+CD25+叉頭样转录因子3阳性(Foxp3+)调节性T淋巴细胞(Treg)及相关细胞因子、总IgE(TIgE)、特异性IgE(sIgE)在有或无特应征反复喘息幼儿外周血介导的免疫应答差异，为幼儿喘息性疾病的发展预测及治疗提供新思路。方法 选择反复喘息幼儿45例，分为特应征组22例和非特应征组23例，另选20名健康幼儿作为健康对照组，分别检测3组幼儿外周静脉血Treg计数和血清IL-10、IL-4、IL-5、IL-13、IFN-γ、TGF-β及TIgE、sIgE水平。结果 特应征组吸入及食入变应原sIgE阳性率高于非特应征组(P均 0.05)，均高于对照组(P均 0.05)， which were significantly higher than that in the control group (both P < 0.05). In children with repeated wheezing， the proportion of peripheral blood Treg cells was positively correlated with serum IL-10 levels (r = 0.875， P < 0.001). Conclusions Peripheral blood Treg cells， IL-10， IL-4， IL-5， IL-13， TGF-β and IFN-γ may be involved with the infantile wheezing， and play an immunomodulatory role in allergic diseases. The counts of peripheral blood Treg cells is positively correlated with the serum IL-10 levels in infants with repeated wheezing. Treg and IL-10 may serve as novel targets for early prediction and treatment of repeated wheezing in the future. ......