蒋树娟?高晓音?范玲玲?秦道刚?王军

    【摘要】川崎病是一种血管炎性疾病，主要发生于儿童，全球各地均有病例， 其病因及发病机制尚未明确，并发症多样。部分患者在应用丙种球蛋白和阿司匹林初始治疗后，仍持续发热，该类型川崎病被定义为丙种球蛋白非敏感型川崎病。该文报道了2例丙种球蛋白非敏感型川崎病合并严重关节炎的患儿，2例MRI均显示合并关节腔积液。 在接受静脉滴注第2剂丙种球蛋白后，2例患儿发热和关节疼痛症状仍未缓解。最后，主诊医师给予他们口服小剂量泼尼松，2例患儿的体温均降至正常，关节症状均缓解。川崎病相关的严重关节炎发病机制不明确，应受到重视，目前尚无丙种球蛋白非敏感型川崎病合并严重关节炎的相关治疗指南，小剂量泼尼松或有望成为其首选的治疗方案。

    【关键词】丙种球蛋白非敏感型川崎病;关节炎;关节腔积液;泼尼松

    IVIG-resistant Kawasaki disease complicated with severe arthritis and joint effusion： a report of two cases Jiang Shujuan， Gao Xiaoyin， Fan Lingling， Qin Daogang， Wang Jun. Department of Pediatrics， Liaocheng Peoples Hospital， Liaocheng 252000， China

    Corresponding author， Fan Lingling， E-mail： fanlinglingll@ 163. com

    【Abstract】Kawasaki disease (KD) is a febrile vasculitis disease， which mainly occurs in children all over the world. The etiology and pathogenesis of KD remain unknown， and its complications are diverse. Intravenous immune globulin (IVIG)-resistant KD is defined as persistent fever in patients after the initial treatment of IVIG and aspirin. In this article ......