臧乐靖?胡燕

    【摘要】子宫颈锥切术后人乳头瘤病毒(HPV)持续感染是导致高级别鳞状上皮内病变(HSIL)患者病灶残留、复发甚至进展为子宫颈癌的危险因素。子宫颈锥切术后HPV持续感染与病毒、机体、治疗等多方面因素相关，了解其发生的相关因素对提高临床治疗效果、完善术后监测方案、指导女性的生活方式等都将起到重要的作用。该文就HSIL患者子宫颈锥切术后HPV持续感染的病毒因素、机体因素和治疗因素做一综述，以期加深临床医师对相关因素的认识，改善HSIL患者的预后。

    【关键词】高级别鳞状上皮内病变;子宫颈锥切术;人乳头瘤病毒;持续感染

    Research progress on related factors of persistent HPV infection after cervical conization in patients with high-grade squamous intraepithelial lesion Zang Lejing， Hu Yan. Department of Obstetrics and Gynecology， the First Affiliated Hospital of Wenzhou Medical University， Wenzhou 325000， China

    Corresponding author， Hu Yan， E-mail： 627830566@ qq. com

    【Abstract】Persistent human papillomavirus (HPV) infection after cervical conization is a significant risk factor for residual， recurrence of leision and even cervical cancer in patients with high-grade squamous intraepithelial lesion (HSIL). The persistent infection of HPV after cervical conization is associated with multiple factors， such as virus， organism， and clinical treatment， etc. Understanding the associated factors will play an important role in improving the clinical efficacy ......