王锋?丁艳?张焕基

    【摘要】循环游离DNA(cfDNA)是循环体液中游离状态的DNA，其在体内的释放被认为与细胞的坏死、凋亡等相关。近年来cfDNA甲基化检测作为一种“液体活组织检查”技术已成为疾病诊疗中的研究热点。心肌梗死后外周血循环中cfDNA的含量升高，并发现cfDNA升高与心肌梗死后并发症的发生有相关性。近年来通过甲基化模式分析寻找到心肌细胞特异性的cfDNA，使cfDNA检测能够为心肌梗死提供更多客观的评估证据。该文综述近几年国内外cfDNA甲基化模式分析在心肌梗死中的研究进展。

    【关键词】循环游离脱氧核糖核酸;甲基化;液体活组织检查;心源性游离脱氧核糖核酸;

    心肌梗死

    Research progress on circulating cell-free DNA methylation pattern analysis in myocardial infarction Wang Feng， Ding Yan， Zhang Huanji. Department of Cardiology， the Eighth Affiliated Hospital of Sun Yat-sen University， Shenzhen 518033， China

    Corresponding author， Zhang Huanji， E-mail： huanji13688808979@ 163. com

    【Abstract】Circulating cell-free DNA (cfDNA) is the free DNA existing in circulating blood， and its release is related to cell death and apoptosis， etc. In recent years， cfDNA methylation detection， as a “liquid biopsy” technique， has become a hot research topic in the diagnosis and treatment of diseases. The content of cfDNA is increased in the peripheral blood circulation after myocardial infarction， which has been proven to be correlated with the occurrence of complications after myocardial infarction. Through the analysis of cfDNA methylation pattern ......