汤继元?徐博怀?余璐洁?何勇

    【摘要】在变应性鼻炎(AR)的所有治疗方法中，特异性免疫治疗(SIT)是唯一可以通过免疫调节机制改变AR自然进程的疗法，临床常用的有皮下SIT和舌下SIT，近年来新兴的淋巴结内免疫治疗(ILIT)是将变应原制剂直接注射到淋巴结内，能在短期内明显改善患者的临床症状，提高患者的生活质量。和传统的皮下及舌下免疫治疗相比，ILIT具有治疗时间短、药物剂量少、医疗费用低等优点。作为AR患者SIT的新选择，越来越多的学者对ILIT进行了广泛的研究，该文就近年来ILIT的研究进展作一综述。

    【关键词】淋巴结;特异性;免疫治疗;变应性鼻炎;变应原

    Research progress on intralymphatic immunotherapy for allergic rhinitis Tang Jiyuan， Xu Bohuai， Yu Lujie， He Yong. Department of Otorhinolaryngology， Ningbo Seventh Hospital， Ningbo 315000， China

    Corresponding author， He Yong， E-mail： nbhy195@ sina. com

    【Abstract】Among all therapeutic methods for allergic rhinitis (AR)， specific immunotherapy (SIT) is the only therapy which can change the natural course of AR through the mechanism of immune regulation. Subcutaneous and sublingual SIT are commonly employed in clinical practice. In recent years， the emerging intralymphatic immunotherapy (ILIT) by direct administration of the allergen preparations into the lymph nodes can significantly mitigate clinical symptoms and improve the quality of life of patients in a short period of time. Compared with traditional subcutaneous and sublingual immunotherapy ......