Wnt/β-catenin信号通路相关环状RNA在肺癌中的研究进展
王灵霞?严玉兰【摘要】环状RNA(circRNA)是转录组中普遍存在的一种封闭成环RNA分子,参与癌症在内的多种疾病进展。Wnt/β-连环蛋白(β-catenin)信号通路控制着许多驱动癌症发展的细胞过程,circRNA的异常表达可通过包括Wnt/β-catenin信号通路在内的多种特定信号通路促进癌症的发生和发展。近年来多项研究表明Wnt/β-catenin信号通路相关circRNA在肺癌中作为新的生物标志物和治疗靶点的潜能。该文就Wnt/β-catenin信号通路相关circRNA对肺癌的影响做一综述,以期为肺癌诊治研究提供新的思路。
【关键词】环状核糖核酸;肺癌;Wnt/β-catenin信号通路
Research progress on circular RNA related to Wnt/β-catenin signaling pathway in lung cancer Wang Lingxia, Yan Yulan. School of Medicine, Jiangsu University, Zhenjiang 212013, China
Corresponding author, Yan Yulan, E-mail: ylyan2005@ 163. com
【Abstract】Circular RNA (circRNA) is a ubiquitous closed-loop RNA molecule in the transcriptome, which is involved in the progression of many diseases including cancer. The Wnt/β-catenin signaling pathway controls various cellular processes that drive the development of cancer. The abnormal expression of circRNA can promote the occurrence and development of cancer through a variety of specific signaling pathways including the Wnt/β-catenin signaling pathway. In recent years, many studies have shown that the Wnt/β-catenin signaling pathway-associated circRNA has the potential as a novel biomarker and therapeutic target in lung cancer. In the article ......
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