王灵霞?严玉兰

    【摘要】环状RNA(circRNA)是转录组中普遍存在的一种封闭成环RNA分子，参与癌症在内的多种疾病进展。Wnt/β-连环蛋白(β-catenin)信号通路控制着许多驱动癌症发展的细胞过程，circRNA的异常表达可通过包括Wnt/β-catenin信号通路在内的多种特定信号通路促进癌症的发生和发展。近年来多项研究表明Wnt/β-catenin信号通路相关circRNA在肺癌中作为新的生物标志物和治疗靶点的潜能。该文就Wnt/β-catenin信号通路相关circRNA对肺癌的影响做一综述，以期为肺癌诊治研究提供新的思路。

    【关键词】环状核糖核酸;肺癌;Wnt/β-catenin信号通路

    Research progress on circular RNA related to Wnt/β-catenin signaling pathway in lung cancer Wang Lingxia， Yan Yulan. School of Medicine， Jiangsu University， Zhenjiang 212013， China

    Corresponding author， Yan Yulan， E-mail： ylyan2005@ 163. com

    【Abstract】Circular RNA (circRNA) is a ubiquitous closed-loop RNA molecule in the transcriptome， which is involved in the progression of many diseases including cancer. The Wnt/β-catenin signaling pathway controls various cellular processes that drive the development of cancer. The abnormal expression of circRNA can promote the occurrence and development of cancer through a variety of specific signaling pathways including the Wnt/β-catenin signaling pathway. In recent years， many studies have shown that the Wnt/β-catenin signaling pathway-associated circRNA has the potential as a novel biomarker and therapeutic target in lung cancer. In the article ......