彭连军?王红嫚?李有霞?范绍辉?阳曼丽

    【摘要】目的 探討支气管扩张症患者感染多重耐药铜绿假单胞菌(MDRP)的影响因素，为临床合理应用抗菌药物、减少多重耐药菌的产生提供科学依据。方法 回顾性分析因支气管扩张症伴感染导致住院且痰培养分离出铜绿假单胞菌(PA)的患者病历资料，依据药物敏感试验结果分为MDRP组与非MDRP组，采用t检验、χ2检验和Wilcoxon秩和检验对临床资料进行初筛，再行Logistic逐步回归分析，探讨MDRP感染的影响因素。结果 共纳入98株PA，其中MDRP组34株，非MDRP组64株，经统计分析，近1年住院次数(OR = 2.419，95%CI 1.559 ～ 3.752，P < 0.001)、ICU/呼吸重症监护病房(RICU)入住史(OR = 4.486，95%CI 1.290 ～ 15.602，P = 0.018)、咯血(OR = 4.702，95%CI 1.110 ～ 19.918，P = 0.036)是MDRP感染的影响因素。结论 近1年频繁住院、ICU/RICU入住史、咯血是MDRP感染的重要危险因素。

    【关键词】支气管扩张症;铜绿假单胞菌;多重耐药菌;耐药性

    Risk factors for infection of multi-drug resistant Pseudomonas aeruginosa in patients with bron-chiectasis Peng Lianjun， Wang Hongman， Li Youxia， Fan Shaohui， Yang Manli. Department of Respiratory and Critical Care Medicine， the Fifth Affiliated Hospital of Zunyi Medical University， Zhuhai 519100， China

    Corresponding author， Wang Hongman， E-mail： 2496453591@ qq. com

    【Abstract】Objective To explore the risk factors for the infection of multi-drug resistant Pseudomonas aeruginosa (MDRP) in patients with bronchiectasis， and to provide scientific basis for the rational application of antimicrobial agents and the reduction of multi-drug resistant bacteria (MDROs). Method Retrospective analysis was performed on the data of patients who hospitalized with bronchiectasis associated with infection and isolated Pseudomonas aeruginosa (PA) from sputum culture. These cases were divided into MDRP group and non-MDRP group according to drug sensitivity results. Students-test ......