王淑娟?陶利军?李伟

    【摘要】术后认知功能障碍是麻醉和手术后的常见并发症之一，其不仅影响患者生活质量，更给患者家庭和社会带来负担。自20多年前食欲素被发现以来，大量的研究已经积累了具体的证据，表明食欲素可以通过影响不同脑区在调节认知功能中起关键作用，但其具体机制尚未清晰。该文对近年来食欲素影响认知功能的机制研究进行综述，为未来食欲素预防及改善认知功能的具体研究提供参考。

    【关键词】食欲素;认知功能;基底前脑;大脑前额叶;海马区

    Research progress on possible mechanism of orexin affecting cognitive function Wang Shujuan△， Tao Lijun， Li Wei. △Department of Anesthesiology， Ordos Central Hospital， Ordos 017000，China

    Corresponding author， Tao Lijun， E-mail： 50944550@qq.com

    【Abstract】Postoperative cognitive dysfunction is a common complication after anesthesia and surgery， which increases the burden on the family and society. Since the discovery of orexin more than 20 years ago， a large number of studies have accumulated specific evidence indicating that orexin plays a key role in regulating cognitive function by affecting different brain regions. Nevertheless， the specific mechanism is still unclear. In this article， relevant studies analyzing the mechanism of orexin affecting cognitive function in recent years were reviewed， aiming to provide reference for the specific research of the role of orexin in preventing and improving cognitive function in the future. ......