黄天劲 周宇

    【摘要】 氨甲酰磷酸合成酶1(CPS1)是催化尿素循环限速酶之一，主要在肝细胞和肠上皮细胞中表达，正常生理情况下其在清除体内代谢废物氨的过程中起重要作用。研究表明，CPS1基因与肝癌、肺癌、结直肠癌等多种恶性肿瘤关系密切，通过多种信号转导通路或影响嘧啶合成等途径影响细胞增殖、凋亡、迁移等细胞生物学行为，从而影响肿瘤的发生发展或患者的预后。因此，研究CPS1基因与肿瘤的关系，对恶性肿瘤早期诊治、预后评价等方面有重要意义。该文就CPS1基因与肿瘤的关系进行综述。

    【关键词】 CPS1基因;肿瘤;结构;功能

    【Abstract】 Carbamyl phosphate synthase 1 (CPS1) is one of the rate-limiting enzymes in the urea cycle， which is mainly expressed in liver cells and intestinal epithelial cells. Under normal physiological conditions，CPS1 plays an important role in the removal of ammonia， a metabolic waste in the body. Studies have shown that CPS1 gene is intimately related to liver cancer， lung cancer， colorectal cancer and other malignant tumors， and can affect cell proliferation， apoptosis， migration and other cell biological behaviors through a variety of signal transduction pathways or affecting pyrimidine synthesis， thus affecting the occurrence and development of tumors or clinical prognosis of patients. Therefore， analyzing the relationship between CPS1 gene and malignant tumor is of great significance for early diagnosis ......