蒙光雪?马洪?廖德仲

    【摘要】可变剪接的失调可能导致不同癌症在多种病理状态下的剪接缺陷，在癌症诊断和治疗过程中可变剪接事件可能作为潜在的分子标志物。可变剪接不仅增加了人类蛋白质的复杂性，还造成了转录组和蛋白质组表达的多样性。一个基因的不同编码区以不同的方式剪接导致该基因的多种转录状态，最终的蛋白产物可能会具有不同的甚至相互拮抗的功能和结构特征，影响肿瘤的发生、发展。在头颈部鳞状细胞癌(HNSCC)中也发生可变剪接事件，该文就HNSCC中发生可变剪接事件及其机制进行综述。

    【关键词】可变剪接；基因转录；头颈部鳞状细胞癌；RNA结合蛋白；肿瘤

    Mechanism of alternative splicing in gene transcription and research progress in head and neck squamous cell carcinoma Meng Guangxue△， Ma Hong， Liao Dezhong. △School of Stomatology， Guizhou Medical University， Guiyang 550004， China

    Corresponding author， Ma Hong， E-mail： mahong1966@126.com

    【Abstract】Misregulation of alternative splicing may result in splicing defects in different types of cancers under multiple pathological conditions. Alternative splicing events may serve as potential molecular markers during the diagnosis and treatment for cancer. Alternative splicing is not only a key mechanism for increasing the complexity of proteins in human， but also causes a diversity of expression of transcriptomes and proteomes in a tissue-specific manner. Different coding regions of a certain gene can be spliced in different patterns ......