董蓉蓉?杨清锐?麻贞贞

    【摘要】结缔组织病(CTD)是一种常见的慢性自身免疫性疾病，常累及多器官、多系统，其诊断不仅需要临床表现的支持，更有赖于特异性自身抗体的存在。抗氨基甲酰化蛋白(anti-CarP)抗體是近年来新发现的自身抗体，在多种CTD的诊断、分层及治疗评估中发挥重要作用。该文就anti-CarP抗体在CTD中的研究进展进行综述。

    【关键词】抗氨基甲酰化蛋白抗体；结缔组织病；类风湿关节炎；系统性红斑狼疮；系统性硬化病；干燥综合征

    Research progress on anti-carbamylated protein antibodies in connective tissue disease Dong Rongrong， Yang Qingrui， Ma Zhenzhen. Department of Rheumatology and Immunology， Shandong Provincial Hospital， Shandong University， Jinan 250021， China

    Corresponding author， Ma Zhenzhen， E-mail： mazhenzhendz@163.com

    【Abstract】Connective tissue disease (CTD) is a group of chronic autoimmune diseases characterized by pathological changes in systemic organs and multisystems. The diagnosis of CTD mainly depends on clinical manifestations and specific autoantibodies. As a newly discovered autoantibody in recent years， anti-carbamylated protein (anti-CarP) antibodies play an important role in the diagnosis， stratification and treatment evaluation of various CTDs. This article reviews the research progress on anti-CarP antibodies in CTD.

    【Key words】Anti-carbamylated protein antibodies； Connective tissue disease； Rheumatoid arthritis; ......