张芊?张欣?王倩?周夕湲?张丽霞

    【摘要】痤疮样皮疹是一种毛囊皮脂腺的慢性炎症性皮肤病，以丘疹、脓疱、囊肿、结节为主要的皮损表现，多伴有明显的瘙痒。该文报道了1例61岁的女性患者，因肺癌口服厄洛替尼后头皮反复出现红斑、丘疹、糜烂、脓疱合并脱发，皮损处分泌物培养出金黄色葡萄球菌和红色毛癣菌。诊断为头皮痤疮样皮疹、皮肤真菌感染。给予多种药物联合治疗后取得良好的临床效果，治疗过程中未停止口服厄洛替尼。该例提示表皮生长因子受体酪氨酸激酶抑制剂可能引起复发性或难治性的痤疮样皮疹，临床需提高对该不良反应的认识并采取积极的治疗措施，以减少因此而导致的靶向治疗中断甚至停用。

    【关键词】厄洛替尼；痤疮样皮疹；克立硼罗；治疗

    Scalp acneiform rash caused by erlotinib： a case report Zhang Qian△， Zhang Xin， Wang Qian， Zhou Xiyuan， Zhang Lixia.△Institute of Dermatology & Venerology， Sichuan Academy of Medical Sciences， Sichuan Provincial Peoples Hospital， Chengdu 610000， China

    Corresponding author， Zhang Lixia， E-mail： zlx007895@163.com

    【Abstract】Acneiform rash is a chronic inflammatory skin disease involving hair follicle and sebaceous glands， primarily manifested with papules， pustules， cysts and nodules， accompanied by obvious pruritus. Here， we reported a 61-year-old female lung cancer patient presenting with recurrent erythema， papules， erosion， pustules and alopecia after oral administration of erlotinib. Staphylococcus aureus and Trichophyton rubrum were cultured in the secretions from the lesions. She was diagnosed with scalp acneiform rash and fungal skin infection. High clinical efficacy was achieved after combined use of multiple drugs. Oral intake of erlotinib was not discontinued throughout the treatment. This case suggests that epidermal growth factor receptor-tyrosine kinase inhibitors may cause recurrent or refractory acneiform rash. It is necessary to deepen the understanding of these adverse reactions and take active therapeutic measures to avoid the interruption or even discontinuation of targeted therapy. ......