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TEM8在恶性肿瘤中的研究进展
http://www.100md.com 2023年12月30日 新医学 2023年第12期
     黄芙蓉?冯诚天?曹世玉?姜永冬

    【摘要】肿瘤内皮细胞标志物8(TEM8)是一种高度保守的单次跨膜糖蛋白。TEM8是肿瘤内皮标志物家族中较为特别的一员,首次发现于结肠癌组织中,研究表明TEM8在多种恶性肿瘤细胞与肿瘤血管内皮特异性表达,并参与肿瘤增殖、血管形成等恶性生物学行为,是一些恶性肿瘤早期诊断和预后的生物标志物,并可作为恶性肿瘤治疗新靶点。该文将介绍TEM8在恶性肿瘤中的作用机制以及其在临床中的应用进展。

    【关键词】肿瘤内皮细胞标志物8;恶性肿瘤;靶点;机制通路

    Research progress on TEM8 in malignant tumors Huang Furong△, Feng Chengtian,Cao Shiyu, Jiang Yongdong.△Breast Surgery Ward 1, Harbin Medical University Cancer Hospital(Harbin Medical University), Harbin 150000, China

    Corresponding author, Jiang Yongdong, E-mail: jiangyongdonghmu@126.com

    【Abstract】Tumor endothelial marker 8 (TEM8) is a highly-conserved single-shot transmembrane glycoprotein. TEM8 is a special member of the tumor endothelial marker family,which was first discovered in colon cancer tissues. Studies have shown that TEM8 is specifically expressed in a variety of malignant tumor cells and tumor vascular endothelia,and participates in malignant biological behaviors,such as tumor proliferation and angiogenesis,which is a biomarker for early diagnosis and prognosis of some malignant tumors,and can be used as a new target for the treatment of malignant tumors. This article will introduce the mechanism of TEM8 in malignant tumors and its clinical application progress. ......

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