黄芙蓉?冯诚天?曹世玉?姜永冬

    【摘要】肿瘤内皮细胞标志物8(TEM8)是一种高度保守的单次跨膜糖蛋白。TEM8是肿瘤内皮标志物家族中较为特别的一员，首次发现于结肠癌组织中，研究表明TEM8在多种恶性肿瘤细胞与肿瘤血管内皮特异性表达，并参与肿瘤增殖、血管形成等恶性生物学行为，是一些恶性肿瘤早期诊断和预后的生物标志物，并可作为恶性肿瘤治疗新靶点。该文将介绍TEM8在恶性肿瘤中的作用机制以及其在临床中的应用进展。

    【关键词】肿瘤内皮细胞标志物8；恶性肿瘤；靶点；机制通路

    Research progress on TEM8 in malignant tumors Huang Furong△， Feng Chengtian，Cao Shiyu， Jiang Yongdong.△Breast Surgery Ward 1， Harbin Medical University Cancer Hospital(Harbin Medical University)， Harbin 150000， China

    Corresponding author， Jiang Yongdong， E-mail： jiangyongdonghmu@126.com

    【Abstract】Tumor endothelial marker 8 (TEM8) is a highly-conserved single-shot transmembrane glycoprotein. TEM8 is a special member of the tumor endothelial marker family，which was first discovered in colon cancer tissues. Studies have shown that TEM8 is specifically expressed in a variety of malignant tumor cells and tumor vascular endothelia，and participates in malignant biological behaviors，such as tumor proliferation and angiogenesis，which is a biomarker for early diagnosis and prognosis of some malignant tumors，and can be used as a new target for the treatment of malignant tumors. This article will introduce the mechanism of TEM8 in malignant tumors and its clinical application progress. ......