醒脑开窍针刺法干预实验性脑梗塞大鼠热休克蛋白基因表达的研究

http://www.100md.com 2001年2月1日《中国针灸》 2001年第2期

     [摘要] 目的:揭示醒脑开窍针刺法治疗脑梗塞的分子机制。方法:采用分子杂交的技术,观察了实验性脑梗塞大鼠缺血区脑组织HSP⁷⁰mRNA的转录水平,并观察了醒脑开窍针刺法对缺血区脑组织HSP⁷⁰mRNA表达的干预作用。结果: 发现醒脑开窍针刺法可增加梗塞区皮质、纹状体、海马HSP⁷⁰基因的表达。证实了醒脑开窍针刺法对缺血后的脑细胞的保护作用优于常规针刺法,揭示了该法保护脑细胞的部分分子机制。

    [主题词] 脑梗塞/针灸疗法;醒脑开窍;热休克蛋白质类/代谢

    Study on HSP⁷⁰mRNA Expression Intervened by Xingnao Kaiqiao Needling M ethod in Rats of Experimental Cerebral InfarctionMa Yanfan,Wang Shu,Lu Bin,et al(The First Affiliated Hospital of Tianjin College of TCM,300193)[Abstract] Purpose To explore molecular mechanism of Xingnao Kaiqiao nee dling method for treatment of cerebral infarction.Methods Molecular hybridization techniques were used to observe the transcription level of HSP⁷⁰mRNA in the cortex,striatum and hippocampus in rats of middle cerebral artery obstruction,and the effect of Xingnao Kai qiao needling method on HSP⁷⁰mRNA expression.Results Xingnao Kaiqiao needing method increased HSP⁷⁰mRNA expression.Conclusion Xing nai Ka i qiao needling method has a better prote ctive action than that of routine needling method on brain cells after ischemia.[Key words] Cerebral Infarction/acup ther;Consciousness Restor Resuscitat;HeatShock Protein/metab ......

百拇医药网 http://www.100md.com/html/paper/0255-2930/2001/02/18.htm

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