脑卒中后抑郁与血清细胞因子的相关性(1)
【摘 要】 目的：探讨血清细胞因子IL-1β、IL-6、TNF-α与脑卒中后抑郁的相关性。方法：采用酶联免疫吸附法(ELISA)对脑梗死(对照组)及脑梗死后抑郁(研究组)患者各32人在脑梗死后第7和28天分别检测血清IL-1β、IL-6及TNF-α水平。结果：对照组患者第7和第28天的IL-1β、IL-6、TNF-α水平差异无统计学意义(P>0.05)。脑卒中后抑郁组第28天的血清IL-1β、IL-6及TNF-α水平显著高于无抑郁的对照组﹙41.0±4.4/17.6±3.2, 13.5±4.1/5.4±2.0, 34.5±7.6 /20.8±4.3,P<0.01﹚,亦显著高于研究组发病第7天的血清水平(17.3±3.5，5.7±2.0,21.1±4.3,P<0.01﹚；脑卒中后重度抑郁组血清IL-1β、IL-6及TNF-α水平(42.6±3.5, 18.7±6.3、39.0±6.4)显著高于轻度抑郁组(28.7±2.5, 6.8±1.7、26.4±3.2)及中度抑郁组﹙34.3±2.8，9.9±3.4、31.5±3.5，P<0.01﹚，中度抑郁组亦高于轻度抑郁组(P<0.05﹚。结论： IL-1β、IL-6及TNF-α可能在脑卒中后抑郁的发病机理中起着重要作用。
【关键词】 细胞因子；脑卒中后抑郁；病例对照研究
中图分类号：R749.13、R749.41 文献标识码：A 文章编号：1000-6729(2008)002-0101-04
Relationshipbetween Post-stroke Depression and Serum Cytokines
GUO Min，LI Hui-Lan,HUANG Ying-Liu，et al
Department of Neural Medicine,Hainan Provincial People's Hospital,Hainan570311
【Abstract】 Objective：To investigate the relationship between serum cytokines(IL-1β, IL-6 and TNF-α) and post-stroke depression. Methods：Serum IL-1β, IL-6 and TNF-α in stroke patients(n=32)and post-stroke depressive patients (n=32)were measured by ELISA on day 7 and day 28 after stroke.Results：The serum levels of IL-1β, IL-6 and TNF-α of the study groupin day 28 were higher than that ofcontrol group (41.0±4.4/17.6±3.2, 13.5±4.1/5.4±2.0, 34.5±7.6 /20.8±4.3,P, http://www.100md.com(郭 敏 李惠兰 黄影柳 蒋湘玲 黄仕雄 陈 涛 符 明)
【关键词】 细胞因子；脑卒中后抑郁；病例对照研究
中图分类号：R749.13、R749.41 文献标识码：A 文章编号：1000-6729(2008)002-0101-04
Relationshipbetween Post-stroke Depression and Serum Cytokines
GUO Min，LI Hui-Lan,HUANG Ying-Liu，et al
Department of Neural Medicine,Hainan Provincial People's Hospital,Hainan570311
【Abstract】 Objective：To investigate the relationship between serum cytokines(IL-1β, IL-6 and TNF-α) and post-stroke depression. Methods：Serum IL-1β, IL-6 and TNF-α in stroke patients(n=32)and post-stroke depressive patients (n=32)were measured by ELISA on day 7 and day 28 after stroke.Results：The serum levels of IL-1β, IL-6 and TNF-α of the study groupin day 28 were higher than that ofcontrol group (41.0±4.4/17.6±3.2, 13.5±4.1/5.4±2.0, 34.5±7.6 /20.8±4.3,P, http://www.100md.com(郭 敏 李惠兰 黄影柳 蒋湘玲 黄仕雄 陈 涛 符 明)