性相关视觉刺激对右脑Broca区不对称性兴奋的功能核磁共振研究(1)
【摘 要】 目的:了解与视觉性刺激相关的脑功能定位。方法:用张贴广告的形式征集到13例正常女性,通过功能核磁共振比较其观看普通影片和含有性内容图片时的大脑兴奋差异,确定差异有统计学意义的脑区。结果:与中性图片相比,涉性图片激发了广泛的大脑区域,包括侧枕叶皮质、中央后回、顶上小叶、枕叶梭状回、海马等。大部分脑区的兴奋都是左右半球对称的,只有额下回岛盖部(Z=3.64,P<0.0001)和三角部(Z=3.42,P=0.003)为右脑优势。讨论:本文通过功能核磁共振方法发现,当女性受试在被呈示以与性相关的图片时,大脑右半球额下回岛盖部和三角部有显著的不对称兴奋。该脑区可能对性心理调控有重要意义。
【关键词】 性心理;额下回岛盖部和三角部;Broca区;功能核磁共振
中图分类号:C913.14,R395.1 文献标识码:A 文章编号:1000-6729(2010)001-0073-04
doi:10.3969/j.issn.1000-6729.2010.01.017
, http://www.100md.com
Visual sexual stimuli induced asymmetrical activation
on Broca' s area on right hemisphere:anfMRI research
ZHU Xun1,WANG Xiao-Ying2,3,GAO Song2,HU Pei-Cheng1
1Department of Medical Psychology,Peking University Health Science Center,No.38,Xueyuan Road,Haidian District,Beijing 100191,China
2Beijing Key Lab of Medical Physics and Engineering,Peking University,Haidian Chengfulu 201,Beijing 100871,China
, http://www.100md.com
3Department of Radiology,Peking University First Hospital,No.8,Xishiku Street,Xicheng District,Beijing 100034,China
Corresponding author:HU Pei-Cheng,E-mail:pchu@bjmu.edu.cn
【Abstract】 Objective:To investigate the brain activation patten associated with visual sexual stimuli.Method:Thirteen healthy right-handed women were enrolled through advertisements on campus.They were scanned under functional magnetic resonance imaging(fMRI) when they watched emotional neutral films excepts and erotic films excepts.Statistic on theses data reveals the difference of brain activation.Result:The results showed that,compared to emotional neutral films,sexual visual stimuli were associated with the activation of a set of bilateral brain areas including lateral occipital cortex,postcentral gyrus,superior parietal lobule,occipital fusiform gyrus, hippocampus,and so on.Most activated brain areas are bilateral.Only in inferior frontal gyrus pars opercularis(Z=3.64,P<0.0001) and pars triangular(Z=3.42,P=0.003) there were significant right hemispheric activation.Conclusion:fMRI results indicate that inferior frontal gyrus is related to the visual sexual stimuli of women subjects,and is specified on the right hemisphere rather than left one.This sphere-special area may play an important role on sexual message processing.
, http://www.100md.com
【Key words】 sexual message processing;inferior frontal gyrus;Broca's area;fMRI
人脑左半球额下回岛盖部和三角部(Brodmann区 44,45),在传统的大脑功能分区上被认为主要与语言相关,被称为Broca区[1]。电生理,Wada测试以及功能影像研究都表明,Broca区以及同样和语言处理密切相关的Wernicke区,在绝大多数人群(约97%)中均位于大脑左半球[2]。Broca区的已知功能涵盖了语义理解,肢体语言理解,以及对外界事物运动的识别和分析[3-5]。近年来还发现其与音乐的欣赏之间有联系[6]。
Broca区是不多的几个已被确认的左右半球功能不同的区域之一,文献研究表明与语言相关的功能主要由该区域的左半球部处理[2],其对侧半球的功能则较少报道。我们在进行女性性心理过程的研究中,发现其右半球部分于性心理活动有显著的相关性。与性有关的大脑功能研究,国外已有一些报道,其结果包括大脑皮质以及一些皮质下结构如右额叶皮质,下颞叶皮质,左侧扣带回前份,岛叶,枕颞叶,内侧前额叶,眶额叶皮层,中央前-后回,下丘脑,丘脑,小脑及杏仁核的兴奋[7-11]。而以中国女性为对象的研究少见。本文以13例正常女性为样本,来了解与视觉性刺激相关的脑功能定位。
1 对象与方法
1.1 对象
通过在北大医学部张贴广告征召受试。共征得13位健康女性。均无精神及神经疾病史,右利手并报告其性取向为异性,教育程度均为本科以上。年龄24~36岁,平均(27.4±4.5) 岁;均报告月经周期正常,平均周期为(31.6±3.5)天;2位已婚。所有实验者在近期均未接受性激素治疗(例如各类药物避孕)。经过检视实验中得到的高分辨结构像,未发现脑组织和结构有异常。
该研究经过北京大学医学部伦理委员会的批准,并取得了受试签署的知情同意书。所有受试均因参加实验而获得了相应的报酬。, 百拇医药(朱 洵 王霄英 高 嵩 胡佩诚)
【关键词】 性心理;额下回岛盖部和三角部;Broca区;功能核磁共振
中图分类号:C913.14,R395.1 文献标识码:A 文章编号:1000-6729(2010)001-0073-04
doi:10.3969/j.issn.1000-6729.2010.01.017
, http://www.100md.com
Visual sexual stimuli induced asymmetrical activation
on Broca' s area on right hemisphere:anfMRI research
ZHU Xun1,WANG Xiao-Ying2,3,GAO Song2,HU Pei-Cheng1
1Department of Medical Psychology,Peking University Health Science Center,No.38,Xueyuan Road,Haidian District,Beijing 100191,China
2Beijing Key Lab of Medical Physics and Engineering,Peking University,Haidian Chengfulu 201,Beijing 100871,China
, http://www.100md.com
3Department of Radiology,Peking University First Hospital,No.8,Xishiku Street,Xicheng District,Beijing 100034,China
Corresponding author:HU Pei-Cheng,E-mail:pchu@bjmu.edu.cn
【Abstract】 Objective:To investigate the brain activation patten associated with visual sexual stimuli.Method:Thirteen healthy right-handed women were enrolled through advertisements on campus.They were scanned under functional magnetic resonance imaging(fMRI) when they watched emotional neutral films excepts and erotic films excepts.Statistic on theses data reveals the difference of brain activation.Result:The results showed that,compared to emotional neutral films,sexual visual stimuli were associated with the activation of a set of bilateral brain areas including lateral occipital cortex,postcentral gyrus,superior parietal lobule,occipital fusiform gyrus, hippocampus,and so on.Most activated brain areas are bilateral.Only in inferior frontal gyrus pars opercularis(Z=3.64,P<0.0001) and pars triangular(Z=3.42,P=0.003) there were significant right hemispheric activation.Conclusion:fMRI results indicate that inferior frontal gyrus is related to the visual sexual stimuli of women subjects,and is specified on the right hemisphere rather than left one.This sphere-special area may play an important role on sexual message processing.
, http://www.100md.com
【Key words】 sexual message processing;inferior frontal gyrus;Broca's area;fMRI
人脑左半球额下回岛盖部和三角部(Brodmann区 44,45),在传统的大脑功能分区上被认为主要与语言相关,被称为Broca区[1]。电生理,Wada测试以及功能影像研究都表明,Broca区以及同样和语言处理密切相关的Wernicke区,在绝大多数人群(约97%)中均位于大脑左半球[2]。Broca区的已知功能涵盖了语义理解,肢体语言理解,以及对外界事物运动的识别和分析[3-5]。近年来还发现其与音乐的欣赏之间有联系[6]。
Broca区是不多的几个已被确认的左右半球功能不同的区域之一,文献研究表明与语言相关的功能主要由该区域的左半球部处理[2],其对侧半球的功能则较少报道。我们在进行女性性心理过程的研究中,发现其右半球部分于性心理活动有显著的相关性。与性有关的大脑功能研究,国外已有一些报道,其结果包括大脑皮质以及一些皮质下结构如右额叶皮质,下颞叶皮质,左侧扣带回前份,岛叶,枕颞叶,内侧前额叶,眶额叶皮层,中央前-后回,下丘脑,丘脑,小脑及杏仁核的兴奋[7-11]。而以中国女性为对象的研究少见。本文以13例正常女性为样本,来了解与视觉性刺激相关的脑功能定位。
1 对象与方法
1.1 对象
通过在北大医学部张贴广告征召受试。共征得13位健康女性。均无精神及神经疾病史,右利手并报告其性取向为异性,教育程度均为本科以上。年龄24~36岁,平均(27.4±4.5) 岁;均报告月经周期正常,平均周期为(31.6±3.5)天;2位已婚。所有实验者在近期均未接受性激素治疗(例如各类药物避孕)。经过检视实验中得到的高分辨结构像,未发现脑组织和结构有异常。
该研究经过北京大学医学部伦理委员会的批准,并取得了受试签署的知情同意书。所有受试均因参加实验而获得了相应的报酬。, 百拇医药(朱 洵 王霄英 高 嵩 胡佩诚)