脂代谢通路基因与肥胖的相关性研究(3)
[2] 周爱儒,查锡良.生物化学.6版.北京: 人民卫生出版社, 2004:108-119.
[3] 杨智, 刘昭前.PPARγ在脂肪细胞分化和糖脂代谢中的作用.国际病理科学与临床杂志,2008,28(1):14-17.
[4] ORIO F J, MATARESE G, DIBIASE S, et al. Exon 6 and 2 peroxisome proliferators-activated receptor-gamma polymorphisms in polycysticovary syndrome. J Clin Endocrinol Metab, 2003,88(12):5 887-5 892.
[5] MASUD S, YE S, SAS G. Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: A meta-analysis. J Med Genet, 2003,40(10):773-780.
, 百拇医药
[6] 郭旭君,王海俊,马军,等.青少年肥胖和糖代谢异常与PPARγ2基因多态性的相关性研究.中国学校卫生,2008,29(10):890-892.
[7] BEAMER BA, YEN CJ, ANDERSEN RE, et al. Association of the Prol2Ala variant in the peroxisome proliferator-activated receptor-γ2 gene with obesity in two Caucasian populations. J Diabetes, 1998,47(11):1 806-1 808.
[8] 樊丹君,许国强.固醇调节元件结合蛋白与脂质代谢的研究进展.国际内科学杂志,2007,34(3):152-154.
[9] EBERLE D, CLEMENT K, MEYRE D, et al. SREBP-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts. J Diabetes, 2004,53(8):2 153-2 157.
, 百拇医药
[10] 孙楠,刘金泉.固醇元件结合蛋白与脂代谢的基因调控.国外医学内分泌学,2004(Suppl),24:13-15.
[11]SEVER N, YANG T, BROWN MS, et al. Accelerated degradation of HMGCoA reductase mediated by binding of Insig21 to its sterol-sensing domain. J Mol Cell, 2003,11(1):25-33.
[12]WANG HJ, ZHANG H, ZHANG SW, et al. Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents. J Biom Environ Scien, 2008,21(6):528-536.
, 百拇医药
[13]POLLEX RL, BAN MR, YOUNG TK, et al. Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample. J BMC Medical Genetics, 2008,8:80.
[14]焦谊,赵学信,张丽萍,等.β2肾上腺素能受体基因R16G多态与哈萨克族男性肥胖的相关性.中华高血压杂志,2006,14(10):806-810.
[15]DIONNE IJ, GARANT MJ, NOLAN AA, et al. Association between obesity and a polymorphism in the beta(1)-adrenoceptor gene (Gly389Arg ADRB1) in Caucasian women. Int J Obes Relat Metab Disord, 2002,26(5):633-639.
, 百拇医药
[16]LINNE Y, DAHLMAN I, HOFFSTEDT J. Beta1-Adrenoceptor gene polymorphism predicts long-term changes in body weight. J IntJ Obes (Lond), 2005,29(5):458-462.
[17]OHSHIRO Y, HAYASHI M, YABIKU K, et al. Mutations in the beta1 adrenergic receptor gene and massive obesity in Japanese. J Diabetes Res Clin Pract, 2008,80(2):213-217.
[18]PEREIRA AC, FLORIANO MS, MOTA GF, et al. Beta 2 adrenoceptor functional gene variants, obesity, and blood pressure level interactions in the genral population J. Hypertension, 2003,42(4):685-692.
, 百拇医药
[19]MASUO K, KATSUYA T, KAWAGUCHI, et al. Rebound weight gain as associated with high plasma norepinephrine levels that are mediated through polymorphisms in the beta2-adrenoceptor. Am J Hypertens, 2005,18(11):1 508-1 516.
[20]WIDEN E, LEHTO M, KANNINEN T, et al. Association of apolymophism in the β3-adrenergic receptor Gene with features of the insulin resistancesyndrome in Finns J. N Engl J Med, 1995,333(6):348-351.
[21]CLEMENT K, VAISSE C, MANNING B, et al. Genetic variation in β3-drenergic receptor and an increased capacity to gain weight in patients with morbid obesity J. N Engl J Med, 1995,333(6):352-354.
, http://www.100md.com
[22]ARASHIRO R, KATSUREN K, FUKUYAMA S, et al. Effect of Trp64 Argmutation of the Beta 32 adrenergic recep tor gene and C16 1T substitution of the peroxisome poliferator activated recep tor gama gene on obesity in Japanese children J. Pediatr Int, 2003,45(2):135-141.
[23]张季红,李敏,徐佩茹,等.新疆乌鲁木齐地区哈萨克族学龄儿童β_3-AR基因变异的分布特点.新疆医科大学学报, 2008,31(1):74-77.
[24]陈肖俊,汪大望,张木勋,等.温州地区汉族人群G蛋白β3亚基C825T基因多态性与肥胖的相关性研究.中华内分泌代谢杂志, 2006,22(2):162-166.
, 百拇医药
[25]STEFAN N, STUMVOLL M, MACHICAO F, et al. C825T polymorphism of the G protein beta3 subunit is associated with obesity but not with insulin sensitivity. J Obes Res, 2004,12:679-683.
[26]张利红,张立杰,杨公社,等.一种调控脂解的重要蛋白-围脂滴蛋白(Perilipin).中国生物化学与分子生物学报, 2006,22(12):931-934.
[27]韩丽红.激素敏感脂肪酶及与代谢性疾病关系.遵义医学院学报, 2005,28(6):566-567.
(收稿日期:2009-02-15), 百拇医药(王 都 王海俊 马 军 王 燕)
[3] 杨智, 刘昭前.PPARγ在脂肪细胞分化和糖脂代谢中的作用.国际病理科学与临床杂志,2008,28(1):14-17.
[4] ORIO F J, MATARESE G, DIBIASE S, et al. Exon 6 and 2 peroxisome proliferators-activated receptor-gamma polymorphisms in polycysticovary syndrome. J Clin Endocrinol Metab, 2003,88(12):5 887-5 892.
[5] MASUD S, YE S, SAS G. Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: A meta-analysis. J Med Genet, 2003,40(10):773-780.
, 百拇医药
[6] 郭旭君,王海俊,马军,等.青少年肥胖和糖代谢异常与PPARγ2基因多态性的相关性研究.中国学校卫生,2008,29(10):890-892.
[7] BEAMER BA, YEN CJ, ANDERSEN RE, et al. Association of the Prol2Ala variant in the peroxisome proliferator-activated receptor-γ2 gene with obesity in two Caucasian populations. J Diabetes, 1998,47(11):1 806-1 808.
[8] 樊丹君,许国强.固醇调节元件结合蛋白与脂质代谢的研究进展.国际内科学杂志,2007,34(3):152-154.
[9] EBERLE D, CLEMENT K, MEYRE D, et al. SREBP-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts. J Diabetes, 2004,53(8):2 153-2 157.
, 百拇医药
[10] 孙楠,刘金泉.固醇元件结合蛋白与脂代谢的基因调控.国外医学内分泌学,2004(Suppl),24:13-15.
[11]SEVER N, YANG T, BROWN MS, et al. Accelerated degradation of HMGCoA reductase mediated by binding of Insig21 to its sterol-sensing domain. J Mol Cell, 2003,11(1):25-33.
[12]WANG HJ, ZHANG H, ZHANG SW, et al. Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents. J Biom Environ Scien, 2008,21(6):528-536.
, 百拇医药
[13]POLLEX RL, BAN MR, YOUNG TK, et al. Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample. J BMC Medical Genetics, 2008,8:80.
[14]焦谊,赵学信,张丽萍,等.β2肾上腺素能受体基因R16G多态与哈萨克族男性肥胖的相关性.中华高血压杂志,2006,14(10):806-810.
[15]DIONNE IJ, GARANT MJ, NOLAN AA, et al. Association between obesity and a polymorphism in the beta(1)-adrenoceptor gene (Gly389Arg ADRB1) in Caucasian women. Int J Obes Relat Metab Disord, 2002,26(5):633-639.
, 百拇医药
[16]LINNE Y, DAHLMAN I, HOFFSTEDT J. Beta1-Adrenoceptor gene polymorphism predicts long-term changes in body weight. J IntJ Obes (Lond), 2005,29(5):458-462.
[17]OHSHIRO Y, HAYASHI M, YABIKU K, et al. Mutations in the beta1 adrenergic receptor gene and massive obesity in Japanese. J Diabetes Res Clin Pract, 2008,80(2):213-217.
[18]PEREIRA AC, FLORIANO MS, MOTA GF, et al. Beta 2 adrenoceptor functional gene variants, obesity, and blood pressure level interactions in the genral population J. Hypertension, 2003,42(4):685-692.
, 百拇医药
[19]MASUO K, KATSUYA T, KAWAGUCHI, et al. Rebound weight gain as associated with high plasma norepinephrine levels that are mediated through polymorphisms in the beta2-adrenoceptor. Am J Hypertens, 2005,18(11):1 508-1 516.
[20]WIDEN E, LEHTO M, KANNINEN T, et al. Association of apolymophism in the β3-adrenergic receptor Gene with features of the insulin resistancesyndrome in Finns J. N Engl J Med, 1995,333(6):348-351.
[21]CLEMENT K, VAISSE C, MANNING B, et al. Genetic variation in β3-drenergic receptor and an increased capacity to gain weight in patients with morbid obesity J. N Engl J Med, 1995,333(6):352-354.
, http://www.100md.com
[22]ARASHIRO R, KATSUREN K, FUKUYAMA S, et al. Effect of Trp64 Argmutation of the Beta 32 adrenergic recep tor gene and C16 1T substitution of the peroxisome poliferator activated recep tor gama gene on obesity in Japanese children J. Pediatr Int, 2003,45(2):135-141.
[23]张季红,李敏,徐佩茹,等.新疆乌鲁木齐地区哈萨克族学龄儿童β_3-AR基因变异的分布特点.新疆医科大学学报, 2008,31(1):74-77.
[24]陈肖俊,汪大望,张木勋,等.温州地区汉族人群G蛋白β3亚基C825T基因多态性与肥胖的相关性研究.中华内分泌代谢杂志, 2006,22(2):162-166.
, 百拇医药
[25]STEFAN N, STUMVOLL M, MACHICAO F, et al. C825T polymorphism of the G protein beta3 subunit is associated with obesity but not with insulin sensitivity. J Obes Res, 2004,12:679-683.
[26]张利红,张立杰,杨公社,等.一种调控脂解的重要蛋白-围脂滴蛋白(Perilipin).中国生物化学与分子生物学报, 2006,22(12):931-934.
[27]韩丽红.激素敏感脂肪酶及与代谢性疾病关系.遵义医学院学报, 2005,28(6):566-567.
(收稿日期:2009-02-15), 百拇医药(王 都 王海俊 马 军 王 燕)