盐霉素纳米结构脂质载体的制备及处方优化(3)
2.4.2 模型拟合 采用Design-Expert 8.0软件,根据拟合优度(R)和置信度(P)对表2的数据结果进行数学模型预测,多元线性拟合,评价指标与各因素的函数关系如下:Y1=110.75+2.26X1-16.86X2-1.15X3+24.47X4-1.44X1X2-2.27X1X3-2.95X1X4-0.97X2X3+2.92X2X4+0.86X3X4-6.86X12+1.02X22-3.42X32+4.95X42+0.95X1X2X3+1.65X1X2X4+2.17X1X3X4-2.23X2X3X4+4.72X12X2+1.40X12X3-26.12X12X4+1.93X1X22-0.96X1X2X3X4-14.20X12X22(R2=0.999 9,P<0.000 1);
Y2=-27.17+0.15X1+2.00X2+0.70X3-0.50X4-0.036X1X2+0.16X1X3+0.23X1X4-0.54X2X3-0.076X2X4-0.35X3X4+0.97X12-0.058X22-0.058X32+0.52X42-0.049X1X2X3+0.011X1X2X4-0.19X1X3X4+0.036X2X3X4-1.05X12X2-3.13X12X3-1.61X12X4-0.63X1X22-0.051X1X2X3X4+4.01X12X22(R2=0.998 9 ......
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