胰岛素受体底物的功能及其基因多态性与2型糖尿病的关系(6)
[14] SUN XJ，WANG LM，ZHANG Y，et al. Role of IRS-2 in insulin and cytokine signalling[J]. Nature，1995，377(6545)：173-177.
[15] WITHERS DJ，GUTIERREZ JS，TOWERY H，et al. Disruption of IRS-2 causes type 2 diabetes in mice[J]. Nature，1998，391(6670)：900-904.
[16] LAVAN BE，LIENHARD GE. The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase[J]. J Biol Chem，1993，268(8)：5921-5928.
, http://www.100md.com
[17] LAVAN BE，LANE WS，LIENHARD GE. The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family[J]. J Biol Chem，1997，272(17)：11439-11443.
[18] KABURAGI Y，SATOH S，TAMEMOTO H，et al. Role of insulin receptor substrate-1 and pp60 in the regulation of insulin-induced glucose transport and GLUT4 translocation in primary adipocytes[J]. J Biol Chem，1997，272(41)：25839-25844.
, 百拇医药 [19] ESCRIBANO O，ARRIBAS M，VALVERDE AM，et al. IRS-3 mediates insulin-induced glucose uptake in differentiated IRS-2(-/-) brown adipocytes[J]. Mol Cell Endocrinol，2007，268(1/2)：1-9.
[20] ZHOU L，CHEN H，XU P，et al. Action of insulin receptor substrate-3 (IRS-3) and IRS-4 to stimulate translocation of GLUT4 in rat adipose cells[J]. Mol Endocrinol，1999，13(3)：505-514.
[21] TSURUZOE K，EMKEY R，KRIAUCIUNAS KM，et al. Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling[J]. Mol Cell Biol，2001，21(1)：26-38.
, http://www.100md.com
[22] LAVAN BE，FANTIN VR，CHANG ET，et al. A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family[J]. J Biol Chem，1997，272(34)：21403-21407.
[23] 張垚，李林鲜，李悦恒，等.胰岛素受体底物家族与2型糖尿病关系性的研究进展[J].现代生物医学进展，2007，7(2)：312-315、320.
[24] CAI D，DHE-PAGANON S，MELENDEZ PA，et al. Two new substrates in insulin signaling，IRS5/DOK4 and IRS6/DOK5[J]. J Biol Chem，2003，278(28)：25323-25330.
, 百拇医药
[25] VERSTEYHE S，BLANQUART C，HAMPE C，et al. Insulin receptor substrates-5 and -6 are poor substrates for the insulin receptor[J]. Mol Med Rep，2010，3(1)：189- 193.
[26] HITMAN GA，HAWRAMI K，MCCARTHY MI，et al. Insulin receptor substrate-1 gene mutations in NIDDM； implications for the study of polygenic disease[J]. Diabetologia，1995，38(4)：481-486.
[27] ZHANG C，BAO W，RONG Y，et al. Genetic variants and the risk of gestational diabetes mellitus：a systematic review[J]. Hum Reprod Update，2013，19(4)：376-390.
[28] DZIWURA J，BI?CZAK-KULETA A，MIAZGOWSKI T，et al. The associations between G972R polymorphism of the IRS-1 gene，insulin resistance，salt sensitivity and non- dipper hypertension[J]. Hypertens Res，2011，34(10)：1082-1086., 百拇医药(孙加琳 荆凡波 徐文 全香花 李晓 郭切 李欣 隋忠国)
[15] WITHERS DJ，GUTIERREZ JS，TOWERY H，et al. Disruption of IRS-2 causes type 2 diabetes in mice[J]. Nature，1998，391(6670)：900-904.
[16] LAVAN BE，LIENHARD GE. The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase[J]. J Biol Chem，1993，268(8)：5921-5928.
, http://www.100md.com
[17] LAVAN BE，LANE WS，LIENHARD GE. The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family[J]. J Biol Chem，1997，272(17)：11439-11443.
[18] KABURAGI Y，SATOH S，TAMEMOTO H，et al. Role of insulin receptor substrate-1 and pp60 in the regulation of insulin-induced glucose transport and GLUT4 translocation in primary adipocytes[J]. J Biol Chem，1997，272(41)：25839-25844.
, 百拇医药 [19] ESCRIBANO O，ARRIBAS M，VALVERDE AM，et al. IRS-3 mediates insulin-induced glucose uptake in differentiated IRS-2(-/-) brown adipocytes[J]. Mol Cell Endocrinol，2007，268(1/2)：1-9.
[20] ZHOU L，CHEN H，XU P，et al. Action of insulin receptor substrate-3 (IRS-3) and IRS-4 to stimulate translocation of GLUT4 in rat adipose cells[J]. Mol Endocrinol，1999，13(3)：505-514.
[21] TSURUZOE K，EMKEY R，KRIAUCIUNAS KM，et al. Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling[J]. Mol Cell Biol，2001，21(1)：26-38.
, http://www.100md.com
[22] LAVAN BE，FANTIN VR，CHANG ET，et al. A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family[J]. J Biol Chem，1997，272(34)：21403-21407.
[23] 張垚，李林鲜，李悦恒，等.胰岛素受体底物家族与2型糖尿病关系性的研究进展[J].现代生物医学进展，2007，7(2)：312-315、320.
[24] CAI D，DHE-PAGANON S，MELENDEZ PA，et al. Two new substrates in insulin signaling，IRS5/DOK4 and IRS6/DOK5[J]. J Biol Chem，2003，278(28)：25323-25330.
, 百拇医药
[25] VERSTEYHE S，BLANQUART C，HAMPE C，et al. Insulin receptor substrates-5 and -6 are poor substrates for the insulin receptor[J]. Mol Med Rep，2010，3(1)：189- 193.
[26] HITMAN GA，HAWRAMI K，MCCARTHY MI，et al. Insulin receptor substrate-1 gene mutations in NIDDM； implications for the study of polygenic disease[J]. Diabetologia，1995，38(4)：481-486.
[27] ZHANG C，BAO W，RONG Y，et al. Genetic variants and the risk of gestational diabetes mellitus：a systematic review[J]. Hum Reprod Update，2013，19(4)：376-390.
[28] DZIWURA J，BI?CZAK-KULETA A，MIAZGOWSKI T，et al. The associations between G972R polymorphism of the IRS-1 gene，insulin resistance，salt sensitivity and non- dipper hypertension[J]. Hypertens Res，2011，34(10)：1082-1086., 百拇医药(孙加琳 荆凡波 徐文 全香花 李晓 郭切 李欣 隋忠国)