纳米载药系统应用于缺血性脑卒中的研究进展(6)
[34] YEMI?CI M， G?RSOY-?ZDEMIR Y，CABAN S，et al.Transport of a caspase inhibitor across the blood-brain barrier by chitosan nanoparticles[J]. Methods Enzymol，2012，508：253-269.
[35] GAO W，ZHANG Y，ZHANG Q，et al. Nanoparticle-hydrogel：a hybrid biomaterial system for localized drug delivery[J]. Ann Biomed Eng，2016，44(6)：2049-2061.
[36] EMERICH DF，SILVA E，ALI O，et al. Injectable VEGF hydrogels produce near complete neurological and anatomical protection following cerebral ischemia in rats[J].Cell Transplant，2010，19(9)：1063-1071.
, http://www.100md.com
[37] TENG Y，JIN H，NAN D，et al. In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model[J]. Bioact Mater，2018，3(1)：102-109.
[38] STOLL G，BENDSZUS M. New approaches to neuroimaging of central nervous system inflammation[J]. Curr Opin Neurol，2010，23(3)：282-286.
[39] MARINA K，KYRIAKI T，CHANIOTAKIS NA. Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications[J]. Int J Nanomedicine，2016，11：1-12.
, 百拇医药
[40] QIAO Z，SHI X. Dendrimer-based molecular imaging contrast agents[J]. Prog Polym Sci，2015，44：1-27.
[41] LABIENIEC-WATALA M，WATALA C. PAMAM dendrimers：destined for success or doomed to fail？Plain and modified PAMAM dendrimers in the context of biomedical applications[J]. J Pharm Sci，2015，104(1)：2-14.
[42] KIM ID，LIM CM，KIM JB，et al. Neuroprotection by biodegradable PAMAM ester(e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain[J]. J Control Release，2010，142(3)：422-430.
, 百拇医药
[43] DOBROVOLSKAIA MA. Dendrimers effects on the immune system：insights into toxicity and therapeutic utility[J]. Curr Pharm Des，2017，23(21)：3134-3141.
[44] COSTA PM，BOURGOGNON M，WANG JT，et al. Functionalised carbon nanotubes：from intracellular uptake and cell-related toxicity to systemic brain delivery[J]. J Control Release，2016，241：200-219.
[45] ZHANG L，ALIZADEH D，BADIE B. Carbon nanotube uptake and toxicity in the brain[J]. Methods Mol Biol，2010，625：55-65.
, 百拇医药
[46] KIM CK，KIM T，CHOI IY，et al. Ceria nanoparticles that can protect against ischemic stroke[J]. Angew Chem Int Ed Engl，2012，51(44)：11039-11043.
[47] PENG L，HE X，ZHANG P，et al. Comparative pulmonary toxicity of two ceria nanoparticles with the same primary size[J]. Int J Mol Sci，2014，15(4)：6072-6085.
[48] HAO L，ZOU Z，TIAN H，et al. Stem cell-based therapies for ischemic stroke[J]. Bio Med Res Int，2014：e468748.
[49] LIU H，JABLONSKA A，LI Y，et al. Label-free CEST MRI detection of citicoline-liposome drug delivery in ischemic stroke[J]. Theranostics，2016，6(10)：1588-1600.
(收稿日期：2017-11-14 修回日期：2018-04-03)
(編辑：段思怡), 百拇医药(吴雅云 庞鑫 刘刚)
[35] GAO W，ZHANG Y，ZHANG Q，et al. Nanoparticle-hydrogel：a hybrid biomaterial system for localized drug delivery[J]. Ann Biomed Eng，2016，44(6)：2049-2061.
[36] EMERICH DF，SILVA E，ALI O，et al. Injectable VEGF hydrogels produce near complete neurological and anatomical protection following cerebral ischemia in rats[J].Cell Transplant，2010，19(9)：1063-1071.
, http://www.100md.com
[37] TENG Y，JIN H，NAN D，et al. In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model[J]. Bioact Mater，2018，3(1)：102-109.
[38] STOLL G，BENDSZUS M. New approaches to neuroimaging of central nervous system inflammation[J]. Curr Opin Neurol，2010，23(3)：282-286.
[39] MARINA K，KYRIAKI T，CHANIOTAKIS NA. Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications[J]. Int J Nanomedicine，2016，11：1-12.
, 百拇医药
[40] QIAO Z，SHI X. Dendrimer-based molecular imaging contrast agents[J]. Prog Polym Sci，2015，44：1-27.
[41] LABIENIEC-WATALA M，WATALA C. PAMAM dendrimers：destined for success or doomed to fail？Plain and modified PAMAM dendrimers in the context of biomedical applications[J]. J Pharm Sci，2015，104(1)：2-14.
[42] KIM ID，LIM CM，KIM JB，et al. Neuroprotection by biodegradable PAMAM ester(e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain[J]. J Control Release，2010，142(3)：422-430.
, 百拇医药
[43] DOBROVOLSKAIA MA. Dendrimers effects on the immune system：insights into toxicity and therapeutic utility[J]. Curr Pharm Des，2017，23(21)：3134-3141.
[44] COSTA PM，BOURGOGNON M，WANG JT，et al. Functionalised carbon nanotubes：from intracellular uptake and cell-related toxicity to systemic brain delivery[J]. J Control Release，2016，241：200-219.
[45] ZHANG L，ALIZADEH D，BADIE B. Carbon nanotube uptake and toxicity in the brain[J]. Methods Mol Biol，2010，625：55-65.
, 百拇医药
[46] KIM CK，KIM T，CHOI IY，et al. Ceria nanoparticles that can protect against ischemic stroke[J]. Angew Chem Int Ed Engl，2012，51(44)：11039-11043.
[47] PENG L，HE X，ZHANG P，et al. Comparative pulmonary toxicity of two ceria nanoparticles with the same primary size[J]. Int J Mol Sci，2014，15(4)：6072-6085.
[48] HAO L，ZOU Z，TIAN H，et al. Stem cell-based therapies for ischemic stroke[J]. Bio Med Res Int，2014：e468748.
[49] LIU H，JABLONSKA A，LI Y，et al. Label-free CEST MRI detection of citicoline-liposome drug delivery in ischemic stroke[J]. Theranostics，2016，6(10)：1588-1600.
(收稿日期：2017-11-14 修回日期：2018-04-03)
(編辑：段思怡), 百拇医药(吴雅云 庞鑫 刘刚)