SREBPs天然小分子抑制剂的药理学研究进展(4)
[ 7 ] YOSHIKAWA T，SHIMANO H，AMEMIYA-KUDO M，et al.Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter[J]. Mol Cell Biol，2001，21(9)：2991-3000.
[ 8 ] PORSTMANN T， SANTOS CR， GRIFFITHS B，et al.SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth[J]. Cell Metab，2008，8(3)：224-236.
[ 9 ] FERNANDEZ-HERNANDO C，SU?REZ Y，RAYNER KJ，et al. MicroRNAs in lipid metabolism[J]. Curr Opin Lipidol，2011，22(2)：86-92.
, 百拇医药
[10] BENGOECHEA-ALONSO MT，ERICSSON J. A phosphorylation cascade controls the degradation of active SREBP1[J]. J Biol Chem，2009，284(9)：5885-5895.
[11] PETERSON TR，SENGUPTA SS，HARRIS TE，et al.mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway[J]. Cell，2011，146(3)：408-420.
[12] BEGUM A，SANDHYA S，SHAFFATH ALI S，et al. An in-depth review on the medicinal flora Rosmarinus officinalis(Lamiaceae)[J]. Acta Sci Pol Technol Aliment，2013，12(1)：61-73.
, 百拇医药
[13] XIE ZS，ZHONG LJ，WAN XM，et al. Petroleum ether sub-fraction of rosemary extract improves hyperlipidemia and insulin resistance by inhibiting SREBPs[J]. Chin J Nat Med，2016，14(10)：746-756.
[14] XIE ZS，WAN XM，ZHONG LJ，et al. Carnosic acid alleviates hyperlipidemia and insulin resistance by promoting the degradation of SREBPs via the 26S proteasome[J]. J Funct Foods，2017，31：217-228.
[15] PIL HWANG Y，GYUN KIM H，CHOI JH，et al. 3-Caffeoyl，4-dihydrocaffeoylquinic acid from Salicornia herbacea attenuates high glucose-induced hepatic lipogenesis in human HepG2 cells through activation of the liver kinase B1 and silent information regulator T1/AMPK-dependent pathway[J]. Mol Nutr Food Res，2013，57(3)：471-482.
, http://www.100md.com
[16] HAM JR，LEE HI，CHOI RY，et al. Anti-steatotic and anti-inflammatory roles of syringic acid in high-fat diet-induced obese mice[J]. Food Funct，2016，7(2)：689-697.
[17] ASANO L，WATANABE M，RYODEN Y，et al. Vitamin D metabolite，25-hydroxyvitamin D，regulates lipid metabolism by inducing degradation of SREBP/SCAP[J]. Cell Chem Biol，2017，24(2)：207-217.
[18] QUAN HY，KIM DY，KIM SJ，et al. Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway[J].Biochem Pharmacol，2013，85(9)：1330-1340.
[19] TANG JJ，LI JG，QI W，et al. Inhibition of SREBP by a small molecule，betulin，improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques[J].Cell Metab，2011，13(1)：44-56., http://www.100md.com(谢治深 赵振彪 张振强 王辉)
[ 8 ] PORSTMANN T， SANTOS CR， GRIFFITHS B，et al.SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth[J]. Cell Metab，2008，8(3)：224-236.
[ 9 ] FERNANDEZ-HERNANDO C，SU?REZ Y，RAYNER KJ，et al. MicroRNAs in lipid metabolism[J]. Curr Opin Lipidol，2011，22(2)：86-92.
, 百拇医药
[10] BENGOECHEA-ALONSO MT，ERICSSON J. A phosphorylation cascade controls the degradation of active SREBP1[J]. J Biol Chem，2009，284(9)：5885-5895.
[11] PETERSON TR，SENGUPTA SS，HARRIS TE，et al.mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway[J]. Cell，2011，146(3)：408-420.
[12] BEGUM A，SANDHYA S，SHAFFATH ALI S，et al. An in-depth review on the medicinal flora Rosmarinus officinalis(Lamiaceae)[J]. Acta Sci Pol Technol Aliment，2013，12(1)：61-73.
, 百拇医药
[13] XIE ZS，ZHONG LJ，WAN XM，et al. Petroleum ether sub-fraction of rosemary extract improves hyperlipidemia and insulin resistance by inhibiting SREBPs[J]. Chin J Nat Med，2016，14(10)：746-756.
[14] XIE ZS，WAN XM，ZHONG LJ，et al. Carnosic acid alleviates hyperlipidemia and insulin resistance by promoting the degradation of SREBPs via the 26S proteasome[J]. J Funct Foods，2017，31：217-228.
[15] PIL HWANG Y，GYUN KIM H，CHOI JH，et al. 3-Caffeoyl，4-dihydrocaffeoylquinic acid from Salicornia herbacea attenuates high glucose-induced hepatic lipogenesis in human HepG2 cells through activation of the liver kinase B1 and silent information regulator T1/AMPK-dependent pathway[J]. Mol Nutr Food Res，2013，57(3)：471-482.
, http://www.100md.com
[16] HAM JR，LEE HI，CHOI RY，et al. Anti-steatotic and anti-inflammatory roles of syringic acid in high-fat diet-induced obese mice[J]. Food Funct，2016，7(2)：689-697.
[17] ASANO L，WATANABE M，RYODEN Y，et al. Vitamin D metabolite，25-hydroxyvitamin D，regulates lipid metabolism by inducing degradation of SREBP/SCAP[J]. Cell Chem Biol，2017，24(2)：207-217.
[18] QUAN HY，KIM DY，KIM SJ，et al. Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway[J].Biochem Pharmacol，2013，85(9)：1330-1340.
[19] TANG JJ，LI JG，QI W，et al. Inhibition of SREBP by a small molecule，betulin，improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques[J].Cell Metab，2011，13(1)：44-56., http://www.100md.com(谢治深 赵振彪 张振强 王辉)