蔡薇薇

    中圖分类号 R965 文献标志码 A 文章编号 1001-0408(2018)17-2342-05

    DOI 10.6039/j.issn.1001-0408.2018.17.09

    摘 要 目的：研究雷贝拉唑(RPZ)对大鼠体内氯吡格雷(CLP)抗血小板聚集作用和代谢的影响。方法：将40只SD大鼠随机分为空白对照组、RPZ组、CLP组、RPZ+CLP组、CLP+RPZ组，每组8只，CLP和RPZ 的给药剂量分别为6.75、0.9 mg/kg，两药给药间隔2 h，连续给药14 d。检测各组大鼠血小板聚集率(MPA)、血小板活化指数(PRI)、胃黏膜损伤评分以及血药浓度[氯吡格雷羧酸(CA)及CLP活性巯基代谢物衍生物(AM)]，并采用Pearson相关性分析法分析MPA和PRI分别与CA、AM的关系。结果：与空白对照组比较，CLP组、RPZ+CLP组和CLP+RPZ组大鼠的MPA、PRI均明显降低(P0.05)。与CLP组比较，RPZ+CLP组和CLP+RPZ组大鼠的MPA、PRI均明显升高(P0.05)。MPA和PRI均与AM呈负相关性(r=-0.689、-0.765，P0.05)。结论：RPZ对CLP的抗血小板作用、致胃黏膜损伤有一定的抑制作用，两药的给药顺序不影响CLP的代谢。

    关键词 氯吡格雷；雷贝拉唑；抗血小板聚集；代谢；相互作用；大鼠

    ABSTRACT OBJECTIVE： To study the effects of rabeprazole (RPZ) on in vivo anti-platelet aggregation and metabolism of clopidogrel in rats. METHODS： Totally 40 SD rats were randomly divided into blank control group， RPZ group， CLP group， RPZ+CLP group and CLP+RPZ group， with 8 rats in each group. The dose of CLP and RPZ were 6.75 and 0.9 mg/kg， with medication interval of 2 h， for consecutive 14 d. The maximal platelet aggregation (MPA)， platelet reaction index (PRI)， gastric mucosal injury score and blood concentration [carboxylic acid of clopidogrel (CA) and active metabolite of clopidogrel (AM) were detected. The relationship of MPA and PRI with CA and AM were analyzed by Pearson relation analysis. RESULTS： Compared with blank control group ......