白头翁皂苷B4对肝癌细胞Huh—7及其荷瘤裸鼠肿瘤的抑制作用及机制研究(6)
[19] 王晓霞，刘天龙，刘晶，等.黄芪甲苷对D-半乳糖诱导原代培养心肌细胞凋亡的保护作用及机制研究[J].中国药房，2018，29(9)：1189-1193.
[20] LIU Q，CHEN W，JIAO Y，et al. Pulsatilla saponin A，an active molecule from Pulsatilla chinensis，induces cancer cell death and inhibits tumor growth in mouse xenograft models[J]. J Surg Res，2014，188(2)：387-395.
[21] HONG SW，JUNG KH，LEE HS，et al. SB365 inhibits angiogenesis and induces apoptosis of hepatocellular carcinoma through modulation of PI3K/Akt/mTOR signaling pathway[J]. Cancer Sci，2012，103(11)：1929-1937.
[22] 田龙夫，张琦，王波涛，等.血根碱通过调控PI3K/Akt信号通路诱导胰腺癌细胞凋亡的机制[J].中国实验方剂学杂志，2018，24(19)：166-171.
[23] YAO N，LI YJ，ZHANG DM，et al. B4G2 induces mitochondrial apoptosis by the ROS-mediated opening of Ca2+-dependent permeability transition pores[J]. Cell Phy- siol Biochem，2015，37(3)：838-852.
[24] ZHANG Y，BAO J，WANG K，et al. Pulsatilla saponin D inhibits autophagic flux and synergistically enhances the anticancer activity of chemotherapeutic agents against HeLa cells[J]. Am J Chin Med，2015，43(8)：1657-1670.
[25] ZHENG Y，ZHOU F，WU X，et al. 23-Hydroxybetulinic acid from Pulsatilla chinensis (Bunge) Regel synergizes the antitumor activities of doxorubicin in vitro and in vivo[J]. J Ethnopharmacol，2010，128(3)：615-622.
(收稿日期：2018-10-11 修回日期：2019-01-11)
(編辑：邹丽娟), http://www.100md.com(薛淑一 李明春 苗青 周煜)
[20] LIU Q，CHEN W，JIAO Y，et al. Pulsatilla saponin A，an active molecule from Pulsatilla chinensis，induces cancer cell death and inhibits tumor growth in mouse xenograft models[J]. J Surg Res，2014，188(2)：387-395.
[21] HONG SW，JUNG KH，LEE HS，et al. SB365 inhibits angiogenesis and induces apoptosis of hepatocellular carcinoma through modulation of PI3K/Akt/mTOR signaling pathway[J]. Cancer Sci，2012，103(11)：1929-1937.
[22] 田龙夫，张琦，王波涛，等.血根碱通过调控PI3K/Akt信号通路诱导胰腺癌细胞凋亡的机制[J].中国实验方剂学杂志，2018，24(19)：166-171.
[23] YAO N，LI YJ，ZHANG DM，et al. B4G2 induces mitochondrial apoptosis by the ROS-mediated opening of Ca2+-dependent permeability transition pores[J]. Cell Phy- siol Biochem，2015，37(3)：838-852.
[24] ZHANG Y，BAO J，WANG K，et al. Pulsatilla saponin D inhibits autophagic flux and synergistically enhances the anticancer activity of chemotherapeutic agents against HeLa cells[J]. Am J Chin Med，2015，43(8)：1657-1670.
[25] ZHENG Y，ZHOU F，WU X，et al. 23-Hydroxybetulinic acid from Pulsatilla chinensis (Bunge) Regel synergizes the antitumor activities of doxorubicin in vitro and in vivo[J]. J Ethnopharmacol，2010，128(3)：615-622.
(收稿日期：2018-10-11 修回日期：2019-01-11)
(編辑：邹丽娟), http://www.100md.com(薛淑一 李明春 苗青 周煜)