【摘要】 目的：探讨绝经前和绝经后患者应用激素替代治疗(HRT)和植物雌激素(PE)治疗对围绝经期综合征的疗效，以期提高围绝经期患者生活质量. 方法：采用前瞻性研究，绝经前患者102例，绝经后患者76例. 其中HRT组106例、PE组72例. 观察患者在用药前、用药3 mo后的围绝经期症状及血脂变化，并观察两种治疗方法的副作用. 结果：两组患者的围绝经期症状均有明显减轻，但PE的作用明显次于HRT (P<0.05)；HRT组中患者血脂中低密度脂蛋白较用药前明显下降(P<0.05)，高密度脂蛋白较用药前明显升高(P<0.05)；而PE组中患者血脂波谱无明显改变；治疗过程中所引起的副作用HRT组明显高于PE组(P<0.05). 结论：HRT和PE均能明显减轻患者的围绝经期症状，HRT能改善血脂波谱状态，而PE能减少患者因服药带来的副作用.

    【关键词】 激素替代疗法；植物;雌激素类；围绝经期综合征；血脂； 副作用

    【Abstract】AIM: To compare the treatment effects of hormone replacement therapy (HRT) and phytoestrogen (PE) for perimenopausal women. METHODS: Totally 178 patients (102 premenopausal and 76 postmenopausal women) were randomely divided into 2 groups: 106 were given HRT and 76 were given PE for 3 months. The side effects were compared between the 2 therapies. RESULTS: After 3 months of treatment ......