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Analysis and thinking on status of constituent library of raditional Chinese medicines in China
ZHAO Li-mei1，2， TAN Ning-hua1*
(1. State Key Laboratory of Phytochemistry and Plant Resources in West China， Kunming Institute of Botany， Chinese Academy of Sciences， Kunming 650201， China；2. Graduate University of Chinese Academy of Sciences， Beijing 100049， China)
[Abstract]Natural products from traditional Chinese medicines (TCMs) are one of the important sources for drug discovery. Systematic investigation on chemical constituents of TCMs plays one key role in TCMs R & D. Research and development on the constituent library of TCMs including the constituent repository and database (eCL-TCMs) is significant for the modernization of TCMs and new drug R & D. This paper reviews the status of current compound libraries and databases in China， analyzes some key problems， and proposes the necessity and ideas of the running eCL-TCMs supported by the National New Drug Innovation Great Project of China (2011ZX09307-002-02). The eCL-TCMs are large-scale， high-quality， comprehensive， standard， open-access， and are integrated with quality control system， drug screening and discovery platforms.
[Key words]constituent library of traditional Chinese medicines； eCL-TCMs； constituent repository； database
doi：10.4268/cjcmm20122003
[责任编辑孔晶晶], http://www.100md.com(赵丽梅， 谭宁华)
Analysis and thinking on status of constituent library of raditional Chinese medicines in China
ZHAO Li-mei1，2， TAN Ning-hua1*
(1. State Key Laboratory of Phytochemistry and Plant Resources in West China， Kunming Institute of Botany， Chinese Academy of Sciences， Kunming 650201， China；2. Graduate University of Chinese Academy of Sciences， Beijing 100049， China)
[Abstract]Natural products from traditional Chinese medicines (TCMs) are one of the important sources for drug discovery. Systematic investigation on chemical constituents of TCMs plays one key role in TCMs R & D. Research and development on the constituent library of TCMs including the constituent repository and database (eCL-TCMs) is significant for the modernization of TCMs and new drug R & D. This paper reviews the status of current compound libraries and databases in China， analyzes some key problems， and proposes the necessity and ideas of the running eCL-TCMs supported by the National New Drug Innovation Great Project of China (2011ZX09307-002-02). The eCL-TCMs are large-scale， high-quality， comprehensive， standard， open-access， and are integrated with quality control system， drug screening and discovery platforms.
[Key words]constituent library of traditional Chinese medicines； eCL-TCMs； constituent repository； database
doi：10.4268/cjcmm20122003
[责任编辑孔晶晶], http://www.100md.com(赵丽梅， 谭宁华)