基于糖代谢酶调节作用的中药抗糖尿病研究进展(9)
[79] Jang S M， Kim M J， Choi M S， et al. Inhibitory effects of ursolic acid on hepatic polyol pathway and glucose production in streptozotocin-induced diabetic mice[J]. Metabolism， 2010， 59(4)： 512.
[80] Kang L J， Lee H B， Bae H J， et al. Antidiabetic effect of propolis： reduction of expression of glucose-6-phosphatase through inhibition of Y279 and Y216 autophosphorylation of GSK-3alpha/beta in HepG2 cells [J]. Phytother Res， 2010， 24： 1554.
Research progress of effect of anti-diabetic traditional Chinese medicines based on regulation of glucose metabolic enzyme
JI Liu， TANG Xin-qiang， PENG Jin-yong
(1. College of Pharmacy， Dalian Medical University， Dalian 116044， China；
2. Department of Pharmacy， the First Affiliated Hospital of Dalian Medical University， Dalian 116044， China)
[Abstract] Diabetes is a global threat threatening human health in the world， with an increasing incidence rate in recent years. The disorder of glucose metabolism is one of the major factors. As relevant glucose metabolic enzymes such as α-glucosidase， glucose-6-phosphatase (G-6-P)， glycogen phosphorylase (GP) and glycogen synthase kinase-3 (GSK-3) get involved in and control the process of glucose metabolism， the regulation of the activity of glucose metabolic enzymes is of significance to the treatment of diabetes. Traditional Chinese medicines (TCMs) have been widely researched because of their low toxicology and high efficiency， and many extracts and components from TCMs have been proven to be regulators of glucose metabolic enzymes. Compared with anti-diabetic western medicines， anti-diabetic TCMs feature safety， reliability and low price. This essay summarizes the anti-diabetic effect of TCMs on regulating glucose metabolic enzymes.
[Key words] diabetes； glucose metabolic enzymes； traditional Chinese medicine； anti-diabetic drug
doi：10.4268/cjcmm20122303
[责任编辑 马超一], http://www.100md.com(吉柳 汤新强 彭金咏)
[80] Kang L J， Lee H B， Bae H J， et al. Antidiabetic effect of propolis： reduction of expression of glucose-6-phosphatase through inhibition of Y279 and Y216 autophosphorylation of GSK-3alpha/beta in HepG2 cells [J]. Phytother Res， 2010， 24： 1554.
Research progress of effect of anti-diabetic traditional Chinese medicines based on regulation of glucose metabolic enzyme
JI Liu， TANG Xin-qiang， PENG Jin-yong
(1. College of Pharmacy， Dalian Medical University， Dalian 116044， China；
2. Department of Pharmacy， the First Affiliated Hospital of Dalian Medical University， Dalian 116044， China)
[Abstract] Diabetes is a global threat threatening human health in the world， with an increasing incidence rate in recent years. The disorder of glucose metabolism is one of the major factors. As relevant glucose metabolic enzymes such as α-glucosidase， glucose-6-phosphatase (G-6-P)， glycogen phosphorylase (GP) and glycogen synthase kinase-3 (GSK-3) get involved in and control the process of glucose metabolism， the regulation of the activity of glucose metabolic enzymes is of significance to the treatment of diabetes. Traditional Chinese medicines (TCMs) have been widely researched because of their low toxicology and high efficiency， and many extracts and components from TCMs have been proven to be regulators of glucose metabolic enzymes. Compared with anti-diabetic western medicines， anti-diabetic TCMs feature safety， reliability and low price. This essay summarizes the anti-diabetic effect of TCMs on regulating glucose metabolic enzymes.
[Key words] diabetes； glucose metabolic enzymes； traditional Chinese medicine； anti-diabetic drug
doi：10.4268/cjcmm20122303
[责任编辑 马超一], http://www.100md.com(吉柳 汤新强 彭金咏)