藤黄化学生物学研究进展(8)
[77]Yang J， Ding L， Hu L， et al. Metabolism of gambogic acid in rats： a rare intestinal metabolic pathway responsible for its final disposition [J]. Drug Metab Dispos， 2011， 39(4)： 617.
Recent advances in chemistry and biology of gamboge
YANG Jing1，6， DING Li1*， LIU Wen-yuan1， FENG Feng2，3， GUO Qing-long3， 4， YOU Qi-dong3， 4， 5
(1. Department of Pharmaceutical Analysis， Nanjing 210009， China； 2. Department of Phytochemistry， Nanjing 210009， China； 3. Jiangsu Key Laboratory of Carcinogenesis and Intervention， Nanjing 210009， China； 4. State Key Laboratory of Natural Medicines， Nanjing 210009， China； 5. Department of Medicinal Chemistry， China Pharmaceutical University， Nanjing 210009， China； 6. Department of Biochemistry， Vanderbilt University， Nashville， Tennessee 37235，USA)
[Abstract]Gamboge， the resin of Garcinia hanburyi has had a long history of use as the traditional dye as well as a complementary and alternative medicine. The antitumor activities of gamboge have been well demonstrated by inhibiting the growth and progression of cancer cells both in vitro and in vivo. In order to further clarify the mode of action of gamboge， there are three key questions needed to be answered， including what′s in gamboge？ How do the chemical components from gamboge work on cancer cells？ How do biological systems work on the chemical components from gamboge after administration？ In this review， we summarize the explorations of the answers toward these questions according to the recent progress in both of chemistry and biology research of gamboge. In addition， the implication in the future research and discovery of the caged G. xanthones as anticancer agents is also discussed.
[Key words]gamboge； gambogic acid； antitumor； target protein； α， β-unsaturated ketone； Michael addition reaction； metabolism； sulfonation
doi：10.4268/cjcmm20130105[责任编辑陈玲], 百拇医药(杨靖，丁黎，柳文媛，冯锋，郭青龙，尤启冬)
Recent advances in chemistry and biology of gamboge
YANG Jing1，6， DING Li1*， LIU Wen-yuan1， FENG Feng2，3， GUO Qing-long3， 4， YOU Qi-dong3， 4， 5
(1. Department of Pharmaceutical Analysis， Nanjing 210009， China； 2. Department of Phytochemistry， Nanjing 210009， China； 3. Jiangsu Key Laboratory of Carcinogenesis and Intervention， Nanjing 210009， China； 4. State Key Laboratory of Natural Medicines， Nanjing 210009， China； 5. Department of Medicinal Chemistry， China Pharmaceutical University， Nanjing 210009， China； 6. Department of Biochemistry， Vanderbilt University， Nashville， Tennessee 37235，USA)
[Abstract]Gamboge， the resin of Garcinia hanburyi has had a long history of use as the traditional dye as well as a complementary and alternative medicine. The antitumor activities of gamboge have been well demonstrated by inhibiting the growth and progression of cancer cells both in vitro and in vivo. In order to further clarify the mode of action of gamboge， there are three key questions needed to be answered， including what′s in gamboge？ How do the chemical components from gamboge work on cancer cells？ How do biological systems work on the chemical components from gamboge after administration？ In this review， we summarize the explorations of the answers toward these questions according to the recent progress in both of chemistry and biology research of gamboge. In addition， the implication in the future research and discovery of the caged G. xanthones as anticancer agents is also discussed.
[Key words]gamboge； gambogic acid； antitumor； target protein； α， β-unsaturated ketone； Michael addition reaction； metabolism； sulfonation
doi：10.4268/cjcmm20130105[责任编辑陈玲], 百拇医药(杨靖，丁黎，柳文媛，冯锋，郭青龙，尤启冬)