红花龙胆化学成分研究(5)
2. State Key Laboratory of Natural Medicines， China Pharmaceutical University， Nanjing 210009， China)
[Abstract] Objective： To determine the chemical constituents of Gentiana rhodantha. Method： To isolate the constituents， column chromatography over silica gel， MCI， Sephadex LH-20 and C18 reverse-phased silica gel were used. Spectroscopic methods were used to elucidate the structures of the isolated compounds. Result： Sixteen compounds were isolated and elucidated as ten phonemic compounds， namely 1，3，7，8-tetrahydroxylxanthone (1)， rhodanthenone D (2)， 1，3，6，7-tetrahydroxylxanthone (3)， 1，3，7-trihydroxy-4，8-dimethoxyxanthone (4)， quercetin (5)， isoorientin (6)， mangiferin (7)， norswertianolin (8)， gallic acid ethyl ester (9) and salicylic acid (10)， and six triterpenes including α-amyrin(11)， erythrodiol 3-O-palmitate (12)， ursolic aldehyde (13)， uvaol 3-O-acetyl (14)， ursolic acid (15) and 2α-hydroxyursolic acid (16). Conclusion： Compounds 4-6， 8， 10-12， 15 and 16 were isolated from this plant for the first time. Compounds 1 and 3 were obtained firstly from the genus Gentiana and compounds 9， 13-14 were firstly from the family Gentianaceae.
[Key words] Gentiana； Gentiana rhodantha； chemical constituents； structural elucidation
doi：10.4268/cjcmm20130314
[责任编辑 孔晶晶], 百拇医药(陈云，王国凯，武璨，秦民坚)
[Abstract] Objective： To determine the chemical constituents of Gentiana rhodantha. Method： To isolate the constituents， column chromatography over silica gel， MCI， Sephadex LH-20 and C18 reverse-phased silica gel were used. Spectroscopic methods were used to elucidate the structures of the isolated compounds. Result： Sixteen compounds were isolated and elucidated as ten phonemic compounds， namely 1，3，7，8-tetrahydroxylxanthone (1)， rhodanthenone D (2)， 1，3，6，7-tetrahydroxylxanthone (3)， 1，3，7-trihydroxy-4，8-dimethoxyxanthone (4)， quercetin (5)， isoorientin (6)， mangiferin (7)， norswertianolin (8)， gallic acid ethyl ester (9) and salicylic acid (10)， and six triterpenes including α-amyrin(11)， erythrodiol 3-O-palmitate (12)， ursolic aldehyde (13)， uvaol 3-O-acetyl (14)， ursolic acid (15) and 2α-hydroxyursolic acid (16). Conclusion： Compounds 4-6， 8， 10-12， 15 and 16 were isolated from this plant for the first time. Compounds 1 and 3 were obtained firstly from the genus Gentiana and compounds 9， 13-14 were firstly from the family Gentianaceae.
[Key words] Gentiana； Gentiana rhodantha； chemical constituents； structural elucidation
doi：10.4268/cjcmm20130314
[责任编辑 孔晶晶], 百拇医药(陈云，王国凯，武璨，秦民坚)