附子毒性研究进展(5)
Beijing 100193， China； 2. China Academy of Chinese Medical Sciences， Beijing 100700， China)
[Abstract] Aconite has the efficacy of reviving yang for resuscitation， dispelling cold and relieving pain， which is widely used in clinic， and shows unique efficacy in treating severe diseases. However， aconite has great toxicity， with obvious cardio-toxicity and neurotoxicity. Its toxicological mechanism main shows in the effect on voltage-dependent sodium channels， release of neurotransmitters and changes in receptors， promotion of lipid peroxidation and cell apoptosis in heart， liver and other tissues. Aconite works to reduce toxicity mainly through compatibility and processing. Besides traditional processing methods， many new modern processing techniques could also help achieve the objectives of detoxification and efficacy enhancement. In order to further develop the medicinal value of aconite and reduce its side effect in clinical application， this article gives comprehensive comments on aconite′s toxicity characteristics， mechanism and detoxification methods on the basis of relevant reports for aconite′s toxicity and the author′s experimental studies.
[Key words] aconite； toxicity； detoxification； application
doi：10.4268/cjcmm20130803
[责任编辑 陈玲], http://www.100md.com(陈荣昌，孙桂波，张强，叶祖光，孙晓波)
[Abstract] Aconite has the efficacy of reviving yang for resuscitation， dispelling cold and relieving pain， which is widely used in clinic， and shows unique efficacy in treating severe diseases. However， aconite has great toxicity， with obvious cardio-toxicity and neurotoxicity. Its toxicological mechanism main shows in the effect on voltage-dependent sodium channels， release of neurotransmitters and changes in receptors， promotion of lipid peroxidation and cell apoptosis in heart， liver and other tissues. Aconite works to reduce toxicity mainly through compatibility and processing. Besides traditional processing methods， many new modern processing techniques could also help achieve the objectives of detoxification and efficacy enhancement. In order to further develop the medicinal value of aconite and reduce its side effect in clinical application， this article gives comprehensive comments on aconite′s toxicity characteristics， mechanism and detoxification methods on the basis of relevant reports for aconite′s toxicity and the author′s experimental studies.
[Key words] aconite； toxicity； detoxification； application
doi：10.4268/cjcmm20130803
[责任编辑 陈玲], http://www.100md.com(陈荣昌，孙桂波，张强，叶祖光，孙晓波)