基于指纹图谱喘平缓释片复杂成分均衡释放的评价(4)
[5] 赖正权， 易宇阳， 廖慧君， 等. 苦木注射液高效液相色谱指纹图谱研究及多成分定量分析[J].中国中药杂志， 2011， 36(13)：1739.
[6] 夏锦辉，刘昌孝.固体药物制剂的体外溶出度的统计学评价分析[J].中国药学杂志，2000，35(2)：130.
Evaluation of balanced release of complex components of
Chuanping sustained tablets based on fingerprint
CAI Yanqu1， CHEN Jian2， XIE Jifu1， CHAI Jinzhen1， LIU Jing1， PENG Qingting1， ZHU Shengshan1*
(1. Research Institute of Traditional Chinese Medicine Development， Guangdong Pharmacological
University， Guangzhou 510006， China；
2. Shiyao Group Ouyi Pharmaceutical Co.， Ltd.， Shijiazhuang 050000， China)
[Abstract] To combine fingerprint and drug release rate in vitro， in order to study in vitro release of complex components of Chuanping sustained tablets， compound traditional Chinese medicine preparation. A qualitative determination of the characteristic peaks of the compound preparations were conducted by the fingerprint. The results of the dissolution rate determination under different release conditions showed that the release of three index components (methamphetamine， pseudoephedrine and scopolamine) of Chuanping sustained tablets was less affected by gastrointestinal factors， with similarity factors being more than 80 with unknown component release curves of three major characteristic peaks in the fingerprint. The qualitative determination proved that multiple components of the compound traditional Chinese medicine preparation was dissolved in vitro at similar rates， realizing the balanced release of complex components of the compound traditional Chinese medicine preparation. This study layed a theoretical and experimental basis for quality evaluation for the compound traditional Chinese medicine preparation.
[Key words] balanced release； compound traditional Chinese preparation； complex component； fingerprint； Chuanping
doi：10.4268/cjcmm20130920
[责任编辑 曹阳阳], http://www.100md.com(蔡延渠，陈健，谢吉福，柴金珍，刘静，彭庆庭，朱盛山)
[6] 夏锦辉，刘昌孝.固体药物制剂的体外溶出度的统计学评价分析[J].中国药学杂志，2000，35(2)：130.
Evaluation of balanced release of complex components of
Chuanping sustained tablets based on fingerprint
CAI Yanqu1， CHEN Jian2， XIE Jifu1， CHAI Jinzhen1， LIU Jing1， PENG Qingting1， ZHU Shengshan1*
(1. Research Institute of Traditional Chinese Medicine Development， Guangdong Pharmacological
University， Guangzhou 510006， China；
2. Shiyao Group Ouyi Pharmaceutical Co.， Ltd.， Shijiazhuang 050000， China)
[Abstract] To combine fingerprint and drug release rate in vitro， in order to study in vitro release of complex components of Chuanping sustained tablets， compound traditional Chinese medicine preparation. A qualitative determination of the characteristic peaks of the compound preparations were conducted by the fingerprint. The results of the dissolution rate determination under different release conditions showed that the release of three index components (methamphetamine， pseudoephedrine and scopolamine) of Chuanping sustained tablets was less affected by gastrointestinal factors， with similarity factors being more than 80 with unknown component release curves of three major characteristic peaks in the fingerprint. The qualitative determination proved that multiple components of the compound traditional Chinese medicine preparation was dissolved in vitro at similar rates， realizing the balanced release of complex components of the compound traditional Chinese medicine preparation. This study layed a theoretical and experimental basis for quality evaluation for the compound traditional Chinese medicine preparation.
[Key words] balanced release； compound traditional Chinese preparation； complex component； fingerprint； Chuanping
doi：10.4268/cjcmm20130920
[责任编辑 曹阳阳], http://www.100md.com(蔡延渠，陈健，谢吉福，柴金珍，刘静，彭庆庭，朱盛山)