银杏内酯组分结构优化实验研究(3)
[6] 洪燕龙， 林晓， 冯怡，等. 含阿魏酸的川芎效应组分缓释微丸的制备及性质考察[J]. 中国中药杂志，2011， 36(4)：439.
Experimental study on structure optimization of ginkgolide components
LIU Dan1，2， JIA Xiao-bin1，2*， XIAO Wei3*
(1. Key Laboratory of New Drug Delivery System of Chinese Meteria Medica，Jiangsu Provincial Academy of Chinese Medicine， Nanjing 210028， China；
2.School of Pharmacy， Jiangsu University， Zhenjiang 212013， China；
3. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process，Jiangsu Kanion Pharmaceutical Co.， Ltd.， Lianyungang 222001， China)
[Abstract] Having searched a large number of literatures， the author found different concepts of traditional Chinese medicine components among pharmacists. Then， what are traditional Chinese medicine components？ The author thinks that traditional Chinese medicine components shall be optimized traditional Chinese medicine components with relatively clear efficient substances， action mechanisms， specific purity and definite internal structure. This experiment preliminarily determined optimized component structures of ginkgolides by comparing the four reported constituents in in vivo and in vitro pharmacodynamic and pharmacological experiments. The experimental design could provide ideas and basis for optimizing traditional Chinese medicine components and determining their matching structures.
[Key words] optimized traditional Chinese medicine component； material basis of traditional Chinese medicine； matching； pharmacodynamic and pharmacological experiment
doi：10.4268/cjcmm20131203, 百拇医药(刘丹 贾晓斌 萧伟)
Experimental study on structure optimization of ginkgolide components
LIU Dan1，2， JIA Xiao-bin1，2*， XIAO Wei3*
(1. Key Laboratory of New Drug Delivery System of Chinese Meteria Medica，Jiangsu Provincial Academy of Chinese Medicine， Nanjing 210028， China；
2.School of Pharmacy， Jiangsu University， Zhenjiang 212013， China；
3. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process，Jiangsu Kanion Pharmaceutical Co.， Ltd.， Lianyungang 222001， China)
[Abstract] Having searched a large number of literatures， the author found different concepts of traditional Chinese medicine components among pharmacists. Then， what are traditional Chinese medicine components？ The author thinks that traditional Chinese medicine components shall be optimized traditional Chinese medicine components with relatively clear efficient substances， action mechanisms， specific purity and definite internal structure. This experiment preliminarily determined optimized component structures of ginkgolides by comparing the four reported constituents in in vivo and in vitro pharmacodynamic and pharmacological experiments. The experimental design could provide ideas and basis for optimizing traditional Chinese medicine components and determining their matching structures.
[Key words] optimized traditional Chinese medicine component； material basis of traditional Chinese medicine； matching； pharmacodynamic and pharmacological experiment
doi：10.4268/cjcmm20131203, 百拇医药(刘丹 贾晓斌 萧伟)