金莲花提取物粉雾剂的制备与体外评价(3)
[6] 游妤， 赵春红， 赵敏，等. 胰岛素吸入粉雾剂的制备及其体外沉积性质[J]. 沈阳药科大学学报， 2008， 25(4)：243.
[7] 王蕾， 唐星. 应用多指标综合评价法优选胸腺五肽干粉吸入剂制备工艺[J]. 中国新药杂志， 2009， 18(11)：1057.
[8] Taki M， Marriott C， Zeng X M， et al. Aerodynamic deposition of combination dry powder inhaler formulations in vitro：a comparison of three impactors[J]. Int J Pharm， 2010， 30(388)：40.
[9] 张幸国， 胡富强， 袁弘，等. 粉雾剂中乳糖对药物在模拟呼吸道沉降部位的影响[J]. 中国医药工业杂志， 2001， 32 (8)：354.
[10] 郭慧丽， 梅兴国， 李高. 两性霉素B脂质干粉吸入剂处方筛选与粉体学性质评价[J]. 医药导报， 2009， 28(2)：225.
[11] 曹伟，陈彦，张振海. 乳糖在干粉吸入剂中的应用[J]. 中国现代应用药学， 2012， 29(7)：591.
[12] Adi H， Larson I， Stewart P J. Adhesion and redistribution of salmeterol xinafoate particles in sugar-based mixtures for inhalation[J]. Int J Pharm，2007(337)：38.
Preparation， in vitro evaluation of excipient-free dry powder inhalation of extraction of Trollius chinensis
FAN Ting， ZHU Yun-feng， CAO Qing-ri， CUI Jing-hao*
(College of Pharmaceutical Science， Suzhou University， Suzhou 215123， China)
[Abstract] To prepare and evaluate dry powder inhalation (DPI) of extraction of Trollius chinensis Bunge(TCB). Orthodox design was employed to optimize the parameters of spray drying to prepare micronized TCB powder， the DPI was prepared by mixing micronized TCB powder and lactose. The results showed that the fine particle fraction (FPF) and emitted dose (ED) of micronized TCB powder was (21.07±1.74)%， (75.31±21.05)%， respectively， and for DPI was (56.4±2.2)%， (95.9±3.0)%， respectively. Therefore， the prepared DPI meeted requirements in the Chinese Pharmacopeia， indicating a good application prospect.
[Key words] Trollius chinensis； spray dying； dry powder inhalation
doi：10.4268/cjcmm20131312
[责任编辑 曹阳阳], http://www.100md.com(樊婷，朱云峰，曹青日，崔京浩)
[7] 王蕾， 唐星. 应用多指标综合评价法优选胸腺五肽干粉吸入剂制备工艺[J]. 中国新药杂志， 2009， 18(11)：1057.
[8] Taki M， Marriott C， Zeng X M， et al. Aerodynamic deposition of combination dry powder inhaler formulations in vitro：a comparison of three impactors[J]. Int J Pharm， 2010， 30(388)：40.
[9] 张幸国， 胡富强， 袁弘，等. 粉雾剂中乳糖对药物在模拟呼吸道沉降部位的影响[J]. 中国医药工业杂志， 2001， 32 (8)：354.
[10] 郭慧丽， 梅兴国， 李高. 两性霉素B脂质干粉吸入剂处方筛选与粉体学性质评价[J]. 医药导报， 2009， 28(2)：225.
[11] 曹伟，陈彦，张振海. 乳糖在干粉吸入剂中的应用[J]. 中国现代应用药学， 2012， 29(7)：591.
[12] Adi H， Larson I， Stewart P J. Adhesion and redistribution of salmeterol xinafoate particles in sugar-based mixtures for inhalation[J]. Int J Pharm，2007(337)：38.
Preparation， in vitro evaluation of excipient-free dry powder inhalation of extraction of Trollius chinensis
FAN Ting， ZHU Yun-feng， CAO Qing-ri， CUI Jing-hao*
(College of Pharmaceutical Science， Suzhou University， Suzhou 215123， China)
[Abstract] To prepare and evaluate dry powder inhalation (DPI) of extraction of Trollius chinensis Bunge(TCB). Orthodox design was employed to optimize the parameters of spray drying to prepare micronized TCB powder， the DPI was prepared by mixing micronized TCB powder and lactose. The results showed that the fine particle fraction (FPF) and emitted dose (ED) of micronized TCB powder was (21.07±1.74)%， (75.31±21.05)%， respectively， and for DPI was (56.4±2.2)%， (95.9±3.0)%， respectively. Therefore， the prepared DPI meeted requirements in the Chinese Pharmacopeia， indicating a good application prospect.
[Key words] Trollius chinensis； spray dying； dry powder inhalation
doi：10.4268/cjcmm20131312
[责任编辑 曹阳阳], http://www.100md.com(樊婷，朱云峰，曹青日，崔京浩)